{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:15:23Z","timestamp":1772507723401,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Clinical and Scientific Funds for High Level Hospitals","award":["2022-1752"],"award-info":[{"award-number":["2022-1752"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Data regarding the association between sleep apnea (SA) and atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) are still limited. We aim to investigate the association of both types of SA, obstructive sleep apnea (OSA) and central sleep apnea (CSA), and nocturnal hypoxemia with AF in HCM. Methods: A total of 606 patients with HCM who underwent sleep evaluations were included. Logistic regression was used to assess the association between sleep disorder and AF. Results: SA was presented in 363 (59.9%) patients, of whom 337 (55.6%) had OSA and 26 (4.3%) had CSA. Patients with SA were older, more often male, had a higher body mass index, and more clinical comorbidities. Prevalence of AF was higher in patients with CSA than patients with OSA and without SA (50.0% versus 24.9% and 12.8%, p &lt; 0.001). After adjustment for age, sex, body mass index, hypertension, diabetes mellitus, cigarette use, New York Heart Association class and severity of mitral regurgitation, SA (OR, 1.79; 95% CI, 1.09\u20132.94) and nocturnal hypoxemia (higher tertile of percentage of total sleep time with oxygen saturation &lt; 90% [OR, 1.81; 95% CI, 1.05\u20133.12] compared with lower tertile) were significantly associated with AF. The association was much stronger in the CSA group (OR, 3.98; 95% CI, 1.56\u201310.13) than in OSA group (OR, 1.66; 95% CI, 1.01\u20132.76). Similar associations were observed when analyses were restricted to persistent\/permanent AF. Conclusion: Both types of SA and nocturnal hypoxemia were independently associated with AF. Attention should be paid to the screening of both types of SA in the management of AF in HCM.<\/jats:p>","DOI":"10.3390\/jcm12041347","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T03:57:16Z","timestamp":1675828636000},"page":"1347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-5718","authenticated-orcid":false,"given":"Haobo","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiansong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMra1710575","article-title":"Clinical Course and Management of Hypertrophic Cardiomyopathy","volume":"379","author":"Maron","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10741-018-9752-6","article-title":"Atrial fibrillation in hypertrophic cardiomyopathy: Prevalence, clinical impact, and management","volume":"24","author":"Garg","year":"2019","journal-title":"Heart Fail. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jacc.2016.11.069","article-title":"Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences","volume":"69","author":"Javaheri","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e015013","DOI":"10.1161\/JAHA.119.015013","article-title":"Implication of Apnea-Hypopnea Index, a Measure of Obstructive Sleep Apnea Severity, for Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy","volume":"9","author":"Xu","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1378\/chest.09-2335","article-title":"Obstructive sleep apnea is common and independently associated with atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"137","author":"Pedrosa","year":"2010","journal-title":"Chest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.amjcard.2010.01.023","article-title":"Interactions between sleep disordered breathing and atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"105","author":"Konecny","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1600959","DOI":"10.1183\/13993003.00959-2016","article-title":"Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep","volume":"49","author":"Randerath","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1164\/rccm.201508-1523OC","article-title":"Central Sleep-disordered Breathing Predicts Incident Atrial Fibrillation in Older Men","volume":"193","author":"May","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e004500","DOI":"10.1161\/JAHA.116.004500","article-title":"Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women","volume":"6","author":"Tung","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2309","DOI":"10.1210\/clinem\/dgab015","article-title":"Association between Obstructive Sleep Apnea and Metabolic Abnormalities in Patients with Hypertrophic Cardiomyopathy","volume":"106","author":"Wang","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","first-page":"e533","article-title":"2020 AHA\/ACC Guideline for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"142","author":"Ommen","year":"2020","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/europace\/eux274","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"20","author":"Calkins","year":"2018","journal-title":"Europace"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/sleep\/32.5.629","article-title":"Validation of a portable monitoring system for the diagnosis of obstructive sleep apnea syndrome","volume":"32","author":"Sartori","year":"2009","journal-title":"Sleep"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"American Academy of Sleep Medicine Task Force (1999). Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep, 22, 667\u2013689.","DOI":"10.1093\/sleep\/22.5.667"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1378\/chest.14-0084","article-title":"Sleep-disordered breathing in hypertrophic cardiomyopathy: Challenges and opportunities","volume":"146","author":"Konecny","year":"2014","journal-title":"Chest"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1164\/ajrccm.160.4.9903020","article-title":"Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure","volume":"160","author":"Sin","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1001\/archinternmed.2009.138","article-title":"Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: Outcomes of sleep disorders in older men (MrOS sleep) study","volume":"169","author":"Mehra","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_18","first-page":"100527","article-title":"Central sleep apnea and atrial fibrillation: A review on pathophysiological mechanisms and therapeutic implications","volume":"30","author":"Sanchez","year":"2020","journal-title":"Int. J. Cardiology. Heart Vasc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrcardio.2015.191","article-title":"Comorbidity of atrial fibrillation and heart failure","volume":"13","author":"Ling","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0735-1097(03)00573-4","article-title":"Myocardial velocity gradient as a noninvasively determined index of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy","volume":"42","author":"Kato","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.5664\/jcsm.6594","article-title":"Nocturnal Desaturation is Associated with Atrial Fibrillation in Patients with Ischemic Stroke and Obstructive Sleep Apnea","volume":"13","author":"Chen","year":"2017","journal-title":"J. Clin. Sleep Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.5664\/jcsm.5278","article-title":"Nocturnal Hypoxemia Is Associated with White Matter Hyperintensities in Patients with a Minor Stroke or Transient Ischemic Attack","volume":"11","author":"Patel","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMoa051001","article-title":"Continuous positive airway pressure for central sleep apnea and heart failure","volume":"353","author":"Bradley","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jacep.2015.02.014","article-title":"Effect of Obstructive Sleep Apnea Treatment on Atrial Fibrillation Recurrence: A Meta-Analysis","volume":"1","author":"Shukla","year":"2015","journal-title":"JACC. Clin. Electrophysiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1347\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:27:51Z","timestamp":1760120871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12041347"],"URL":"https:\/\/doi.org\/10.3390\/jcm12041347","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,8]]}}}