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We set out to determine the predictive factors on patients\u2019 QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: The mean SNOT-22 score was 39. Considering the clinical parameters, the SNOT-22 value was significantly associated with NSAID intolerance (p = 0.04) and the endoscopic polyp score (p = 0.04). A high SNOT-22 value was also correlated with high tissue eosinophilia (p = 0.01) and high IL-8 expression; (4) Conclusions: Eosinophilia, IL-8 expression and NSAID intolerance can be used as predictors of worse QoL in patients with CRSwNP.<\/jats:p>","DOI":"10.3390\/jcm12041391","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T01:35:29Z","timestamp":1675992929000},"page":"1391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-3765","authenticated-orcid":false,"given":"Aina","family":"Brunet","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Bellvitge, 08907 Barcelona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica (IDIBELL), 08908 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Milara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"Pharmacy Unit, University General Hospital Consortium of Valencia, 46014 Valencia, Spain"},{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Fr\u00edas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de Manises, 46940 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Cortijo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain"},{"name":"Research and Teaching Unit, University General Hospital Consortium, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-6292","authenticated-orcid":false,"given":"Miguel","family":"Armengot","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain"},{"name":"Department of Otorhinolaryngology, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain"},{"name":"Molecular, Cellular and Genomic Biomedicine Group, Instituto de Investigaci\u00f3n Sanitaria La Fe, 46020 Valencia, Spain"},{"name":"Surgery Department, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps EPOS 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1749-4486.2012.02527.x","article-title":"Prevalence of Sinonasal Outcome Test (SNOT-22) symptoms in patients undergoing surgery for Chronic Rhinosinusitis","volume":"37","author":"Abdalla","year":"2012","journal-title":"Clin. 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