{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:42:53Z","timestamp":1774352573855,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T00:00:00Z","timestamp":1676160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The introduction of mutation-specific therapy led to a revolution in cystic fibrosis (CF) care. These advances in CF therapies have changed the disease profile from a severe incurable disease with limited survival to a treatable disease with improved quality of life and survival into adulthood. CF patients are now able to plan their future, including marriage and parenthood. Side by side with the optimism, new issues and concerns are arising, including fertility and preparation for pregnancy, maternal and fetal care during pregnancy, and post-partum care. While cystic fibrosis transmembrane regulator (CFTR) modulators show promising results for improving CF lung disease, data on their safety in pregnancy are still limited. We performed a literature review on pregnancy in CF from the past, with the first described pregnancy in 1960, through the current fascinating changes in the era of CFTR modulators, to ongoing studies and future directions. Current advances in knowledge give hope for improved outcomes of pregnancy, towards the best possible prognosis for the mother and for the baby.<\/jats:p>","DOI":"10.3390\/jcm12041468","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T01:48:56Z","timestamp":1676252936000},"page":"1468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pregnancy in Cystic Fibrosis\u2014Past, Present, and Future"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-7617","authenticated-orcid":false,"given":"Michal","family":"Gur","sequence":"first","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children\u2019s Hospital, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa 3525422, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-200X","authenticated-orcid":false,"given":"Mordechai","family":"Pollak","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children\u2019s Hospital, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa 3525422, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-5415","authenticated-orcid":false,"given":"Ronen","family":"Bar-Yoseph","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children\u2019s Hospital, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa 3525422, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Bentur","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Institute and CF Center, Rappaport Children\u2019s Hospital, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa 3525422, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1378\/chest.129.3.706","article-title":"Impact of pregnancy on women with cystic fibrosis","volume":"129","author":"McMullen","year":"2006","journal-title":"Chest"},{"key":"ref_2","first-page":"438","article-title":"Pregnancy and Delivery in a Patient with Cystic Fibrosis of the Pancreas: Report of a case","volume":"16","author":"Siegel","year":"1960","journal-title":"Obstet. 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