{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:56:29Z","timestamp":1771062989750,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Codex Labs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acne vulgaris is a common inflammatory condition that can be associated with profound psychosocial impacts. Conventional treatment includes topical retinoids, benzoyl peroxide, and antimicrobials, and some may cause irritation and skin dryness. In this 8-week open-label study, we examined the effects of a botanical skin care regimen (Codex Labs Shaant Balancing regimen) on mild to moderate facial and truncal acne. Twenty-four male and female subjects between the ages of 12 and 45 years were assessed for eligibility, 20 were enrolled, and 15 completed all study visits. Facial and truncal acne lesion counts, skin hydration, sebum excretion rate, and mood were assessed at baseline, week 4, and week 8. Total facial lesion counts (inflammatory and non-inflammatory lesions) decreased by 20.5% at week 4 (p = 0.06) and by 25.2% at week 8 (p &lt; 0.05). Inflammatory lesion counts on the trunk were found to decrease at week 8 relative to baseline by 48% (p &lt; 0.05). Forehead sebum excretion rate decreased by 40% at week 4 (p = 0.07) and 22% at week 8 (p = 0.08), and cheek skin hydration increased by 27.6% at week 4 (p = 0.14) and 65% at week 8 (p = 0.10). Participants also experienced significant improvement in components of a positive effect, such as feeling \u201cstrong\u201d and \u201cinspired\u201d, and a decrease in negative effects, such as feeling \u201cirritable.\u201d Overall, the botanical skin care regimen was found to be well-tolerated. Our study suggests that a botanical skin care regimen may reduce facial and truncal acne lesion counts, increase skin hydration, reduce sebum production, and augment positive effects and moods in those with mild to moderate facial and truncal acne.<\/jats:p>","DOI":"10.3390\/jcm12041484","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T02:42:33Z","timestamp":1676256153000},"page":"1484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective Evaluation of a Topical Botanical Skin Care Regimen on Mild to Moderate Facial and Truncal Acne and Mood"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-5573","authenticated-orcid":false,"given":"Yvonne","family":"Nong","sequence":"first","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimrit","family":"Gahoonia","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Osteopathic Medicine, Touro University, Vallejo, CA 94592, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"School of Medicine, University of California Davis, Sacramento, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas","family":"Burney","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-8162","authenticated-orcid":false,"given":"Raja K.","family":"Sivamani","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"Pacific Skin Institute, Sacramento, CA 95815, USA"},{"name":"Department of Dermatology, University of California Davis, Davis, CA 95816, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Maloh","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/bjd.12149","article-title":"Epidemiology of acne vulgaris","volume":"168","author":"Bhate","year":"2013","journal-title":"Br. 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