{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:30:15Z","timestamp":1791973815316,"version":"4.4.0"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Gardner\u2019s syndrome (GS) is a combination of polyposis, osteomas, fibromas, and sebaceous cysts. The aim of the study is to highlight whether maxillofacial osteoma could represent an early detection symptom of GS. Patients with suspected osteoma of the jaw underwent genetic and radiographical examinations. The database gathered 19 patients with oral osteoma that was histologically diagnosed; the whole sample was positive for APC gene mutation. Other cranial and peripheral locations were reported. Osteoma of the jaw is a crucial predictive factor of GS, and dentists and oral and maxillofacial surgeons must be aware of the importance of a timely diagnosis.<\/jats:p>","DOI":"10.3390\/jcm12041496","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T01:41:06Z","timestamp":1676338866000},"page":"1496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Osteoma of the Jaw as First Clinical Sign of Gardner\u2019s Syndrome: The Experience of Two Italian Centers and Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-4768","authenticated-orcid":false,"given":"Silvia","family":"D\u2019Agostino","sequence":"first","affiliation":[{"name":"Department of Medical, Oral, and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4012-0782","authenticated-orcid":false,"given":"Fabio","family":"Dell\u2019Olio","sequence":"additional","affiliation":[{"name":"Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-6292","authenticated-orcid":false,"given":"Angela","family":"Tempesta","sequence":"additional","affiliation":[{"name":"Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cervinara","sequence":"additional","affiliation":[{"name":"Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-1201","authenticated-orcid":false,"given":"Antonio","family":"D\u2019Amati","sequence":"additional","affiliation":[{"name":"Operating Unit of Pathological Anatomy, Department of Emergency and Organ Transplantation, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Dolci","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral, and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Favia","sequence":"additional","affiliation":[{"name":"Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9819-6229","authenticated-orcid":false,"given":"Saverio","family":"Capodiferro","sequence":"additional","affiliation":[{"name":"Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5246-1253","authenticated-orcid":false,"given":"Luisa","family":"Limongelli","sequence":"additional","affiliation":[{"name":"Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"bcr2013200293","DOI":"10.1136\/bcr-2013-200293","article-title":"External manifestations of Gardner\u2019s syndrome as the presenting clinical entity","volume":"2014","author":"Agrawal","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1179\/1465313315Y.0000000008","article-title":"Gardner\u2019s Syndrome revisited: A clinical case and overview of the literature","volume":"43","author":"Seehra","year":"2016","journal-title":"J. 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