{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:27:24Z","timestamp":1780565244234,"version":"3.54.1"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and respiratory morbidity. To assess whether respiratory morbidity during the first 2 years of life in infants with left-sided CDH is associated with fetal lung volume (FLV) evaluated by the observed-to-expected FLV ratio (o\/e FLV) on antenatal magnetic resonance imaging (MRI). In this retrospective study, o\/e FLV measures were collected. Respiratory morbidity in the first 2 years of life was studied according to two endpoints: treatment with inhaled corticosteroids for &gt;3 consecutive months and hospitalization for any acute respiratory disease. The primary outcome was a favorable progression defined by the absence of either endpoint. Forty-seven patients were included. The median o\/e FLV was 39% (interquartile range, 33\u201349). Sixteen (34%) infants were treated with inhaled corticosteroids and 13 (28%) were hospitalized. The most efficient threshold for a favorable outcome was an o\/e FLV \u2265 44% with a sensitivity of 57%, specificity of 79%, negative predictive value of 56%, and positive predictive value of 80%. An o\/e FLV \u2265 44% was associated with a favorable outcome in 80% of cases. These data suggest that lung volume measurement on fetal MRI may help to identify children at lower respiratory risk and improve information during pregnancy, patient characterization, decisions about treatment strategy and research, and personalized follow-up.<\/jats:p>","DOI":"10.3390\/jcm12041508","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T01:38:18Z","timestamp":1676425098000},"page":"1508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia"],"prefix":"10.3390","volume":"12","author":[{"given":"Valentine","family":"Cerbelle","sequence":"first","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-4458","authenticated-orcid":false,"given":"K\u00e9vin","family":"Le Duc","sequence":"additional","affiliation":[{"name":"ULR2694 Metrics-Perinatal Environment and Health, Universit\u00e9 de Lille, F-59000 Lille, France"},{"name":"Department of Neonatology, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Mur","sequence":"additional","affiliation":[{"name":"Department of Neonatology, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9loise","family":"Lerisson","sequence":"additional","affiliation":[{"name":"Pediatric Imaging Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Drumez","sequence":"additional","affiliation":[{"name":"ULR 2694-METRICS: \u00c9valuation des Technologies de Sant\u00e9 et des Pratiques M\u00e9dicales, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Sfeir","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Bigot","sequence":"additional","affiliation":[{"name":"Pediatric Imaging Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"},{"name":"Jacquemars Gi\u00e9l\u00e9e Imaging Center, F-59000 Lille, France"},{"name":"G\u00e9n\u00e9rale de Sant\u00e9, La Louvi\u00e8re Ramsay H\u00f4pital, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Verpillat","sequence":"additional","affiliation":[{"name":"Pediatric Imaging Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-0320","authenticated-orcid":false,"given":"Riadh","family":"Boukhris","sequence":"additional","affiliation":[{"name":"Department of Neonatology, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Vaast","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Mordacq","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thumerelle","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Storme","sequence":"additional","affiliation":[{"name":"ULR2694 Metrics-Perinatal Environment and Health, Universit\u00e9 de Lille, F-59000 Lille, France"},{"name":"Department of Neonatology, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit, H\u00f4pital Jeanne de Flandre, CHU Lille, Universit\u00e9 de Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Center for Rare Disease \u201cCongenital Diaphragmatic Hernia\u201d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"ref_1","unstructured":"(2020, June 16). European Platform on Rare Disease Registration. Available online: https:\/\/eu-rd-platform.jrc.ec.europa.eu."},{"key":"ref_2","first-page":"308","article-title":"Lung Growth for Beginners","volume":"1","author":"Kotecha","year":"2000","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/uog.13271","article-title":"Comparison of Ultrasound and Magnetic Resonance Imaging Parameters in Predicting Survival in Isolated Left-Sided Congenital Diaphragmatic Hernia","volume":"43","author":"Bebbington","year":"2014","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-3468(96)90338-3","article-title":"Sonographic Predictors of Survival in Fetal Diaphragmatic Hernia","volume":"31","author":"Metkus","year":"1996","journal-title":"J. Pediatr. Surg."},{"key":"ref_5","unstructured":"(2023, February 13). HAS Avis et D\u00e9cisions de La HAS D\u00e9cision N\u00b02012.0169\/DC\/SBPP Du 24 Octobre 2012 Du Coll\u00e8ge de La Haute Autorit\u00e9 de Sant\u00e9 Adoptant Le Protocole National et de Soins: Hernie Diaphragmatique Cong\u00e9nitale. Available online: https:\/\/www.has-sante.fr\/jcms\/c_1333885\/en\/decision-n2012-0169\/dc\/sbpp-du-24-octobre-2012-du-college-de-la-haute-autorite-de-sante-portant-adoption-du-protocole-national-de-diagnostic-et-de-soins-pour-la-prise-en-charge-de-la-hernie-diaphragmatique-congenitale."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1148\/radiology.219.1.r01ap18236","article-title":"Fetal Lung Volume: Estimation at MR Imaging\u2014Initial Results","volume":"219","author":"Rypens","year":"2001","journal-title":"Radiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jpedsurg.2016.12.008","article-title":"Antenatal Predictors of Outcome in Prenatally Diagnosed Congenital Diaphragmatic Hernia (CDH)","volume":"52","author":"Kuret","year":"2017","journal-title":"J. Pediatr. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2214\/AJR.07.2434","article-title":"Prediction of Mortality and Need for Neonatal Extracorporeal Membrane Oxygenation in Fetuses with Congenital Diaphragmatic Hernia: Logistic Regression Analysis Based on MRI Fetal Lung Volume Measurements","volume":"189","author":"Neff","year":"2007","journal-title":"Am. J. Roentgenol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1148\/radiol.12111512","article-title":"Fetal Lung Volume in Congenital Diaphragmatic Hernia: Association of Prenatal MR Imaging Findings with Postnatal Chronic Lung Disease","volume":"266","author":"Debus","year":"2013","journal-title":"Radiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1148\/radiol.2481070952","article-title":"MR Relative Fetal Lung Volume in Congenital Diaphragmatic Hernia: Survival and Need for Extracorporeal Membrane Oxygenation","volume":"248","author":"Kilian","year":"2008","journal-title":"Radiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000444210","article-title":"Standardized Postnatal Management of Infants with Congenital Diaphragmatic Hernia in Europe: The CDH EURO Consortium Consensus\u20142015 Update","volume":"110","author":"Snoek","year":"2016","journal-title":"Neonatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/apa.14169","article-title":"Review Shows That Implementing a Nationwide Protocol for Congenital Diaphragmatic Hernia Was a Key Factor in Reducing Mortality and Morbidity","volume":"107","author":"Storme","year":"2018","journal-title":"Acta Paediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1053\/jpsu.2001.20031","article-title":"Pulmonary Morbidity in 100 Survivors of Congenital Diaphragmatic Hernia Monitored in a Multidisciplinary Clinic","volume":"36","author":"Muratore","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Benoist, G., Mokhtari, M., Deschildre, A., Khen-Dunlop, N., Storme, L., Benachi, A., and Delacourt, C. (2016). Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155556"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105049","DOI":"10.1016\/j.earlhumdev.2020.105049","article-title":"Early Postnatal Changes of Circulating N-Terminal-pro-B-Type Natriuretic Peptide in Neonates with Congenital Diaphragmatic Hernia","volume":"146","author":"Heindel","year":"2020","journal-title":"Early Hum. Dev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1148\/radiol.2462062166","article-title":"Reliability and Validity of MR Image Lung Volume Measurement in Fetuses with Congenital Diaphragmatic Hernia and in Vitro Lung Models","volume":"246","author":"Kilian","year":"2008","journal-title":"Radiology"},{"key":"ref_17","first-page":"1459","article-title":"Imagiological Methods for Prediction of Fetal Pulmonary Hypoplasia: A Systematic Review","volume":"34","year":"2019","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"ref_18","first-page":"S0022346819308401","article-title":"Discordant Prenatal Ultrasound and Fetal MRI in CDH: Wherein Lies the Truth?","volume":"55","author":"Kim","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/pd.5560","article-title":"Variability in Antenatal Prognostication of Fetal Diaphragmatic Hernia across the North American Fetal Therapy Network (NAFTNet)","volume":"40","author":"Abbasi","year":"2020","journal-title":"Prenat. Diagn."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00330-012-2709-6","article-title":"Liver-to-Thoracic Volume Ratio: Use at MR Imaging to Predict Postnatal Survival in Fetuses with Isolated Congenital Diaphragmatic Hernia with or without Prenatal Tracheal Occlusion","volume":"23","author":"Cannie","year":"2013","journal-title":"Eur. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/NPM-190266","article-title":"Antenatal Management and Outcomes of Pregnancies with Congenital Diaphragmatic Hernia","volume":"13","author":"Tanacan","year":"2020","journal-title":"J. Neonatal-Perinat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jpedsurg.2014.02.048","article-title":"Prenatal MRI Fetal Lung Volumes and Percent Liver Herniation Predict Pulmonary Morbidity in Congenital Diaphragmatic Hernia (CDH)","volume":"49","author":"Zamora","year":"2014","journal-title":"J. Pediatr. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1007\/s00247-019-04478-2","article-title":"A Multifactorial Severity Score for Left Congenital Diaphragmatic Hernia in a High-Risk Population Using Fetal Magnetic Resonance Imaging","volume":"49","author":"Brown","year":"2019","journal-title":"Pediatr. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"51163","DOI":"10.1053\/j.semperi.2019.07.002","article-title":"Prenatal Diagnosis, Imaging, and Prognosis in Congenital Diaphragmatic Hernia","volume":"44","author":"Cordier","year":"2019","journal-title":"Semin. Perinatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1080\/14767058.2017.1299126","article-title":"Observed-to-Expected MRI Fetal Lung Volume Can Predict Long-Term Lung Morbidity in Infants with Congenital Diaphragmatic Hernia","volume":"30","author":"Tsuda","year":"2017","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ppul.20193","article-title":"Long-Term Pulmonary Morbidity in Survivors of Congenital Diaphragmatic Hernia","volume":"39","author":"Trachsel","year":"2005","journal-title":"Pediatr. Pulmonol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jpedsurg.2014.12.007","article-title":"Pulmonary Support on Day of Life 30 Is a Strong Predictor of Increased 1 and 5-Year Morbidity in Survivors of Congenital Diaphragmatic Hernia","volume":"50","author":"Cauley","year":"2015","journal-title":"J. Pediatr. Surg."},{"key":"ref_28","first-page":"173","article-title":"The Pulmonary Outcome of Long-Term Survivors after Congenital Diaphragmatic Hernia Repair","volume":"138","author":"Basek","year":"2008","journal-title":"Swiss Med. Weekly"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jpedsurg.2007.10.049","article-title":"Redefining Outcomes in Right Congenital Diaphragmatic Hernia","volume":"43","author":"Fisher","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/PCC.0b013e3182192aa9","article-title":"Right- versus Left-Sided Congenital Diaphragmatic Hernia: Postnatal Outcome at a Specialized Tertiary Care Center","volume":"13","author":"Schaible","year":"2012","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/pd.5706","article-title":"Is Laterality of Congenital Diaphragmatic Hernia a Reliable Prognostic Factor? French National Cohort Study","volume":"40","author":"Pinton","year":"2020","journal-title":"Prenat. Diagn."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1508\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:35:09Z","timestamp":1760121309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12041508"],"URL":"https:\/\/doi.org\/10.3390\/jcm12041508","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,14]]}}}