{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:44:15Z","timestamp":1769582655609,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Municipal Science and Technology Commission","award":["Z191100006619087"],"award-info":[{"award-number":["Z191100006619087"]}]},{"name":"Beijing Municipal Science and Technology Commission","award":["XMLX202108"],"award-info":[{"award-number":["XMLX202108"]}]},{"name":"Beijing Hospitals Authority Clinical medicine Development of Special Funding Support","award":["Z191100006619087"],"award-info":[{"award-number":["Z191100006619087"]}]},{"name":"Beijing Hospitals Authority Clinical medicine Development of Special Funding Support","award":["XMLX202108"],"award-info":[{"award-number":["XMLX202108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Craniopharyngioma (CP) is a histologically benign tumor with high mortality and morbidity. Although surgical treatment is essential in managing CP, the best surgical approach is debated. A retrospective cohort of 117 patients with adult-onset CP (AOCP) treated between 2018 and 2020 in Beijing Tiantan Hospital was identified and examined. The effects of traditional craniotomy (TC) and endoscopic endonasal transsphenoidal surgery (EETS) on the extent of surgical resection, hypothalamic involvement (HI), postoperative endocrine function, and postoperative weight were compared in the cohort. The cohort comprised 43 males and 74 females, divided into the TC (n = 59) and EETS (n = 58) groups. The EETS group possessed a higher rate of gross total resection (GTR) (adjusted odds ratio (aOR) = 4.08, p = 0.029) and improved HI (aOR = 2.58, p = 0.041) than the TC group. Worse postoperative HI was only observed in the TC group (5 patients). The EETS was associated with fewer adverse hormonal outcomes, including posterior pituitary dysfunction (aOR = 0.386, p = 0.040) and hypopituitarism (aOR = 0.384, p = 0.031). Additionally, multivariate logistic regression analysis confirmed that EETS was related to fewer cases of weight gain &gt;5% (aOR = 0.376, p = 0.034), significant weight change (aOR = 0.379, p = 0.022), and postoperative obesity (aOR = 0.259, p = 0.032). Compared to TC, EETS shows advantages in accomplishing GTR, hypothalamus protection, postoperative endocrine function reservation, and postoperative weight control. These data suggest that the EETS deserves more application in managing patients with AOCP.<\/jats:p>","DOI":"10.3390\/jcm12041578","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T05:11:29Z","timestamp":1676524289000},"page":"1578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Craniotomy and Endoscopic Endonasal Transsphenoidal Surgery on Bodyweight in Adult-Onset Craniopharyngioma: A Single-Center Retrospective Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Yanbin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-8171","authenticated-orcid":false,"given":"Youchao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songbai","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41572-019-0125-9","article-title":"Craniopharyngioma","volume":"5","author":"Merchant","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_2","first-page":"22","article-title":"Surgical management of craniopharyngiomas: A review of 74 cases","volume":"65","author":"Samii","year":"1986","journal-title":"Neurol. Med. Chir."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3171\/2020.11.PEDS20803","article-title":"Comparison of multimodal surgical and radiation treatment methods for pediatric craniopharyngioma: Long-term analysis of progression-free survival and morbidity","volume":"28","author":"Ravindra","year":"2021","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00381-012-1926-2","article-title":"A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma","volume":"29","author":"Clark","year":"2013","journal-title":"Child\u2019s Nerv. Syst."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3171\/2009.7.PEDS09215","article-title":"Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children","volume":"5","author":"Elliott","year":"2010","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.3171\/2010.1.FOCUS09307","article-title":"Craniopharyngioma: A comparison of tumor control with various treatment strategies","volume":"28","author":"Yang","year":"2010","journal-title":"Neurosurg. Focus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3171\/jns.1990.73.1.0003","article-title":"Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients","volume":"73","author":"Curcic","year":"1990","journal-title":"J. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s10143-020-01370-8","article-title":"Approach selection and outcomes of craniopharyngioma resection: A single-institute study","volume":"44","author":"Lei","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11102-012-0437-1","article-title":"Single-surgeon fully endoscopic endonasal transsphenoidal surgery: Outcomes in three-hundred consecutive cases","volume":"16","author":"Mamelak","year":"2013","journal-title":"Pituitary"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"847418","DOI":"10.3389\/fneur.2022.847418","article-title":"Endoscopic Endonasal Transsphenoidal Surgery for Recurrent Craniopharyngiomas","volume":"13","author":"Feng","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.wneu.2011.07.011","article-title":"Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas","volume":"77","author":"Komotar","year":"2012","journal-title":"World Neurosurg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3109\/02688697.2012.654837","article-title":"Endoscopic skull base surgery: A comprehensive comparison with open transcranial approaches","volume":"26","author":"Komotar","year":"2012","journal-title":"Br. J. Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3171\/2015.3.JNS142254","article-title":"Comparative analysis of outcomes following craniotomy and expanded endoscopic endonasal transsphenoidal resection of craniopharyngioma and related tumors: A single-institution study","volume":"124","author":"Jeswani","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2016.9.FOCUS16314","article-title":"Outcomes in transcranial microsurgery versus extended endoscopic endonasal approach for primary resection of adult craniopharyngiomas","volume":"41","author":"Wannemuehler","year":"2016","journal-title":"Neurosurg. Focus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3171\/2020.10.JNS202779","article-title":"The predictive value of intraoperative visual evoked potential for visual outcome after extended endoscopic endonasal surgery for adult craniopharyngioma","volume":"135","author":"Qiao","year":"2021","journal-title":"J. Neurosurg."},{"key":"ref_16","first-page":"e29349","article-title":"Endoscopic Extended Transsphenoidal Surgery for Newly Diagnosed Paediatric Craniopharyngiomas","volume":"68","author":"Amoo","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_17","first-page":"3","article-title":"Pediatric craniopharyngiomas: Classification and treatment according to the degree of hypothalamic involvement","volume":"106","author":"Puget","year":"2007","journal-title":"J. Neurosurg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1603","DOI":"10.1210\/clinem\/dgaa985","article-title":"Preoperative BMI Predicts Postoperative Weight Gain in Adult-onset Craniopharyngioma","volume":"106","author":"Duan","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2265.2005.02231.x","article-title":"Craniopharyngiomas in children and adults: Systematic analysis of 121 cases with long-term follow-up","volume":"62","author":"Karavitaki","year":"2005","journal-title":"Clin. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"694213","DOI":"10.3389\/fendo.2021.694213","article-title":"Risk Factors for Hypothalamic Obesity in Patients With Adult-Onset Craniopharyngioma: A Consecutive Series of 120 Cases","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/neuonc\/nov044","article-title":"Survival, hypothalamic obesity, and neuropsychological\/psychosocial status after childhood-onset craniopharyngioma: Newly reported long-term outcomes","volume":"17","author":"Sterkenburg","year":"2015","journal-title":"Neuro Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cortex.2017.01.017","article-title":"Hypothalamic tumors impact gray and white matter volumes in fronto-limbic brain areas","volume":"89","author":"Thiel","year":"2017","journal-title":"Cortex"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13054-016-1376-4","article-title":"The neurological and cognitive consequences of hyperthermia","volume":"20","author":"Walter","year":"2016","journal-title":"Crit. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.jpeds.2013.12.010","article-title":"Neuropsychological outcome in patients with childhood craniopharyngioma and hypothalamic involvement","volume":"164","author":"Thiel","year":"2014","journal-title":"J. Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3171\/2021.10.PEDS21392","article-title":"A propensity-adjusted comparison of endoscopic endonasal surgery versus transcranial microsurgery for pediatric craniopharyngioma: A single-center study","volume":"29","author":"Wu","year":"2022","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_26","first-page":"1003","article-title":"Endoscopic cranial base surgery: Classification of operative approaches","volume":"62","author":"Esposito","year":"2008","journal-title":"Neurosurgery"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00381-005-1166-9","article-title":"Functional capacity and body mass index in patients with sellar masses\u2014Cross-sectional study on 403 patients diagnosed during childhood and adolescence","volume":"21","author":"Gebhardt","year":"2005","journal-title":"Child\u2019s Nerv. Syst."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1155\/1988\/291847","article-title":"Altered behavior associated with damage to the ventromedial hypothalamus: A distinctive syndrome","volume":"1","author":"Flynn","year":"1988","journal-title":"Behav. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/alr.23009","article-title":"Outcomes of endoscopic endonasal resection of pediatric craniopharyngiomas","volume":"12","author":"Patel","year":"2022","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fendo.2011.00081","article-title":"Long term sequelae of pediatric craniopharyngioma-literature review and 20 years of experience","volume":"2","author":"Cohen","year":"2011","journal-title":"Front. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3171\/2017.10.PEDS17254","article-title":"Therapeutic outcomes of transsphenoidal surgery in pediatric patients with craniopharyngiomas: A single-center study","volume":"21","author":"Yamada","year":"2018","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.beem.2014.03.003","article-title":"The hypothalamic arcuate nucleus and the control of peripheral substrates","volume":"28","author":"Cansell","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1210\/er.2018-00017","article-title":"Pathophysiology and Individualized Treatment of Hypothalamic Obesity Following Craniopharyngioma and Other Suprasellar Tumors: A Systematic Review","volume":"40","author":"Brokke","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-022-02470-6","article-title":"Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of \u03b2-amyloid","volume":"19","author":"Ainiwan","year":"2022","journal-title":"J. Neuroinflammat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/oby.23639","article-title":"Obesity among Asian American people in the United States: A review","volume":"31","author":"Li","year":"2023","journal-title":"Obesity"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4082\/kjfm.2011.32.7.412","article-title":"Obesity, obesity related disease, and disability","volume":"32","author":"Na","year":"2011","journal-title":"Korean J. Fam. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2010.1.FOCUS09303","article-title":"Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity","volume":"28","author":"Nippoldt","year":"2010","journal-title":"Neurosurg. Focus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.amjmed.2004.06.035","article-title":"Endocrine and neuroanatomic features associated with weight gain and obesity in adult patients with hypothalamic damage","volume":"118","author":"Daousi","year":"2005","journal-title":"Am. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1530\/EJE-12-0792","article-title":"Hypothalamic obesity: Prevalence, associations and longitudinal trends in weight in a specialist adult neuroendocrine clinic","volume":"168","author":"Steele","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11060-013-1128-0","article-title":"Tumor origin and growth pattern at diagnosis and surgical hypothalamic damage predict obesity in pediatric craniopharyngioma","volume":"113","author":"Park","year":"2013","journal-title":"J. Neurooncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1055\/s-2001-16855","article-title":"Obesity after childhood craniopharyngioma--German multicenter study on pre-operative risk factors and quality of life","volume":"213","author":"Bueb","year":"2001","journal-title":"Klin. P\u00e4diatrie"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3171\/jns.1996.85.1.0073","article-title":"Management of childhood craniopharyngioma: Can the morbidity of radical surgery be predicted?","volume":"85","author":"Grant","year":"1996","journal-title":"J. Neurosurg."},{"key":"ref_43","first-page":"w14521","article-title":"A ten-year follow-up study of treatment outcome of craniopharyngiomas","volume":"148","author":"Andereggen","year":"2018","journal-title":"Swiss Med. Wkly."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1080\/07315724.2019.1691951","article-title":"Increased Obesity Awareness and Adherence to Healthy Lifestyle-Diet Reduce Metabolic Syndrome Risk in Overweight Children","volume":"39","author":"Bozbulut","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1210\/jc.2002-021180","article-title":"Risk factors for the development of obesity in children surviving brain tumors","volume":"88","author":"Lustig","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1578\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:38:14Z","timestamp":1760121494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12041578"],"URL":"https:\/\/doi.org\/10.3390\/jcm12041578","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}