{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:33Z","timestamp":1787028633641,"version":"build-2736575974"},"reference-count":76,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FRGS","award":["FRGS\/1\/2020\/STG03\/UM\/02\/7"],"award-info":[{"award-number":["FRGS\/1\/2020\/STG03\/UM\/02\/7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: People with multiple sclerosis (PwMS) suffer from some comorbidities, including physical and psychiatric disorders, low quality of life (QoL), hormonal dysregulation, and hypothalamic-pituitary-adrenal axis dysfunction. The current study aimed to investigate the effects of eight weeks of tele-yoga and tele-Pilates on the serum levels of prolactin and cortisol and selected physical and psychological factors. Methods: Forty-five females with relapsing remitting multiple sclerosis, based on age (18\u201365), expanded disability status scale (0\u20135.5), and body mass index (20\u201332), were randomly assigned to tele-Pilates, tele-yoga, or control groups (n = 15). Serum blood samples and validated questionnaires were collected before and after interventions. Results: Following online interventions, there was a significant increase in the serum levels of prolactin (p = 0.004) and a significant decrease in cortisol (p = 0.04) in the time \u00d7 group interaction factors. In addition, significant improvements were observed in depression (p = 0.001), physical activity levels (p &lt; 0.001), QoL (p \u2264 0.001), and the speed of walking (p &lt; 0.001). Conclusion: Our findings suggest that tele-yoga and tele-Pilates training could be introduced as patient-friendly, non-pharmacological, add-on therapeutic methods for increasing prolactin and decreasing cortisol serum levels and achieving clinically relevant improvements in depression, walking speed, physical activity level, and QoL in female MS patients.<\/jats:p>","DOI":"10.3390\/jcm12041585","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T01:32:56Z","timestamp":1676597576000},"page":"1585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Parisa","family":"Najafi","sequence":"first","affiliation":[{"name":"Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hadizadeh","sequence":"additional","affiliation":[{"name":"Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-9599","authenticated-orcid":false,"given":"Jadeera Phaik Geok","family":"Cheong","sequence":"additional","affiliation":[{"name":"Faculty of Sports and Exercise Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-5049","authenticated-orcid":false,"given":"Hamidreza","family":"Mohafez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhailah","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Poursadeghfard","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz 7193635899, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Najafi, P., Hadizadeh, M., Cheong, J.P.G., Mohafez, H., and Abdullah, S. 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