{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:45:38Z","timestamp":1789821938280,"version":"4.0.1"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sytheon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Terminalia chebula (TC) is a medicinal plant that exhibits antioxidant, anti-inflammatory, and antibacterial properties and that is widely used in Ayurveda and herbal formulations. However, the skin effects of TC as an oral supplement have not been studied. The objective of this study is to determine if oral TC fruit extract supplementation can modulate the skin\u2019s sebum production and reduce the appearance of wrinkles. A prospective double-blind placebo-controlled study was conducted on healthy females aged 25\u201365. Subjects were supplemented with an oral placebo or Terminalia chebula (250 mg capsule, Synastol TC) capsules twice daily for eight weeks. A facial image collection and analysis system was used to assess the facial appearance of wrinkle severity. Standardized, non-invasive tools were used to measure facial moisture, sebum production, transepidermal water loss, melanin index and erythema index. For those who had a baseline sebum excretion rate &gt;80 ug\/cm2, TC supplementation produced a significant decrease in forehead sebum excretion rate compared to the placebo at four weeks (\u221217 decrease vs. 20% increase, p = 0.07) and at eight weeks (\u221233% decrease vs. 29% increase, p &lt; 0.01). Cheek erythema decreased by 2.2% at eight weeks, while the placebo treatment increased cheek erythema by 1.5% (p &lt; 0.05). Facial wrinkles decreased by 4.3% in the TC group and increased by 3.9% in the placebo group after eight weeks of supplementation (p &lt; 0.05). TC supplementation reduces facial sebum and improves the appearance of wrinkles. Future studies should consider evaluating oral TC as adjuvant therapy for acne vulgaris.<\/jats:p>","DOI":"10.3390\/jcm12041591","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T01:32:56Z","timestamp":1676597576000},"page":"1591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Randomized Double-Blind Placebo-Controlled Supplementation with Standardized Terminalia chebula Fruit Extracts Reduces Facial Sebum Excretion, Erythema, and Wrinkle Severity"],"prefix":"10.3390","volume":"12","author":[{"given":"Mincy","family":"Chakkalakal","sequence":"first","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-9979","authenticated-orcid":false,"given":"Adrianne","family":"Pan","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Medicine, California Northstate University, Elk Grove, CA 95757, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawnica","family":"Nadora","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Medicine, California Northstate University, Elk Grove, CA 95757, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrit","family":"Gahoonia","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Osteopathic Medicine, Touro University California, Vallejo, CA 94592, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratan","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Sytheon, 10 Waterview Blvd, Parsippany, NJ 07054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Burney","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-456X","authenticated-orcid":false,"given":"Shivani","family":"Thacker","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Shakhbazova","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"School of Medicine, University of California, Riverside, CA 92521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitra","family":"Subramanyam","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Chambers","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Medicine, California Northstate University, Elk Grove, CA 95757, USA"},{"name":"Pacific Skin Institute, Sacramento, CA 95815, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-8162","authenticated-orcid":false,"given":"Raja","family":"Sivamani","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research, Sacramento, CA 95815, USA"},{"name":"College of Medicine, California Northstate University, Elk Grove, CA 95757, USA"},{"name":"Pacific Skin Institute, Sacramento, CA 95815, USA"},{"name":"Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0254-6272(16)30035-8","article-title":"Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine","volume":"36","author":"Jokar","year":"2016","journal-title":"J. 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