{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:57:13Z","timestamp":1791849433864,"version":"4.3.4"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Anesthetic sedatives are widely used for bronchoscopy, and controversy surrounds the safety and efficacy of dexmedetomidine compared to other sedatives. The aim of this study is to evaluate the safety and efficacy of dexmedetomidine in bronchoscopy through a systematic review. (2) Methods: PubMed, Embase, Google Scholar, and Cochrane Library electronic databases were searched for a randomized controlled study of dexmedetomidine (Group D) or other sedative drugs (Group C) for bronchoscopy. Data extraction, quality assessment, and risk of bias analysis were performed in accordance with the preferred reporting items for systematic review and meta-analysis requirements. Meta-analysis was performed using RevMan 5.2. (3) Results: Nine studies were included, with a total of 765 cases. Compared to Group C, the incidence of hypoxemia (OR = 0.40, 95% CI (0.25, 0.64) p = 0.0001, I2 = 8%) and tachycardia (OR = 0.44, 95% CI (0.26,0.74), p = 0.002, I2 = 14%) were lower, but bradycardia (OR = 3.71, 95% CI (1.84, 7.47), p = 0.0002, I2 = 0%) was higher in Group D; no significant difference was observed in other outcome indicators. (4) Conclusions: Dexmedetomidine reduces the incidence of hypoxemia and tachycardia during bronchoscopy but is more likely to provoke bradycardia.<\/jats:p>","DOI":"10.3390\/jcm12041607","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T02:57:22Z","timestamp":1676602642000},"page":"1607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and Efficacy of Dexmedetomidine for Bronchoscopy: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-4379","authenticated-orcid":false,"given":"Qianqian","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Peking University Shougang Hospital, Beijing 100144, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Shougang Hospital, Beijing 100144, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Shougang Hospital, Beijing 100144, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Shougang Hospital, Beijing 100144, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Shougang Hospital, Beijing 100144, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenggang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Shougang Hospital, Beijing 100144, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1183\/09059180.00006412","article-title":"Sedation for flexible bronchoscopy: Current and emerging evidence","volume":"22","author":"Shaefi","year":"2013","journal-title":"Eur. Respir. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1183\/09031936.98.11051147","article-title":"Common fears of patients undergoing bronchoscopy","volume":"11","author":"Poi","year":"1998","journal-title":"Eur. Respir. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2310\/8000.2013.130933","article-title":"Does the sedation regimen affect adverse events during procedural sedation and analgesia in injection drug users?","volume":"15","author":"Andolfatto","year":"2013","journal-title":"CJEM"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thoraxjnl-2013-203618","article-title":"British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: Accredited by NICE","volume":"68","author":"Blaikley","year":"2013","journal-title":"Thorax"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1183\/09031936.00121610","article-title":"Propofol versus propofol plus hydrocodone for flexible bronchoscopy: A randomised study","volume":"38","author":"Schlatter","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1378\/chest.14-1526","article-title":"Therapeutic bronchoscopy for malignant central airway obstruction: Success rates and impact on dyspnea and quality of life","volume":"147","author":"Ost","year":"2015","journal-title":"Chest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/1759-7714.14286","article-title":"Efficacy and safety of EBUS-TBNA under conscious sedation with meperidine and midazolam","volume":"13","author":"Piro","year":"2022","journal-title":"Thorac. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ccm.2017.09.004","article-title":"Sedation in Bronchoscopy: A Review","volume":"39","author":"McCambridge","year":"2018","journal-title":"Clin. Chest Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-540-74806-9_16","article-title":"Midazolam and other benzodiazepines","volume":"182","author":"Olkkola","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.rmed.2004.06.002","article-title":"Premedication for bronchoscopy in older patients: A double-blind comparison of two regimens","volume":"99","author":"Watts","year":"2005","journal-title":"Respir. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lo, Y.L., Lin, T.Y., Fang, Y.F., Wang, T.Y., Chen, H.C., Chou, C.L., Chung, F.T., Kuo, C.H., Feng, P.H., and Liu, C.Y. (2011). Feasibility of bispectral index-guided propofol infusion for flexible bronchoscopy sedation: A randomized controlled trial. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027769"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1183\/09031936.00180808","article-title":"Propofol versus combined sedation in flexible bronchoscopy: A randomised non-inferiority trial","volume":"34","author":"Stolz","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1183\/09031936.00142108","article-title":"Titrated sedation with propofol or midazolam for flexible bronchoscopy: A randomised trial","volume":"34","author":"Clark","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/j.1399-6576.2005.00842.x","article-title":"Comparison of alfetanil and ketamine in combination with propofol for patient-controlled sedation during fiberoptic bronchoscopy","volume":"49","author":"Hwang","year":"2005","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1183\/09031936.00047311","article-title":"It is time for patients to undergo bronchoscopy without discomfort","volume":"38","author":"Gasparini","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1378\/chest.08-2466","article-title":"The old and the new of sedation for bronchoscopy","volume":"135","author":"Jantz","year":"2009","journal-title":"Chest"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4097\/kja.19259","article-title":"Dexmedetomidine: Present and future directions","volume":"72","author":"Lee","year":"2019","journal-title":"Korean, J. Anesthesiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4103\/0970-9185.142846","article-title":"A comparison of dexmedetomidine plus ketamine combination with dexmedetomidine alone for awake fiberoptic nasotracheal intubation: A randomized controlled study","volume":"30","author":"Sinha","year":"2014","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1460-9592.2006.02139.x","article-title":"Hemodynamic and respiratory changes following dexmedetomidine administration during general anesthesia: Sevoflurane vs desflurane","volume":"17","author":"Deutsch","year":"2007","journal-title":"Paediatr. Anaesthesia."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1213\/01.ANE.0000219592.82598.AA","article-title":"A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging","volume":"103","author":"Koroglu","year":"2006","journal-title":"Anesth. Analg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/cc712","article-title":"Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care","volume":"4","author":"Venn","year":"2000","journal-title":"Crit. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1177\/147323001204000415","article-title":"Dexmedetomidine versus midazolam for conscious sedation in postoperative patients undergoing flexible bronchoscopy: A randomized study","volume":"40","author":"Liao","year":"2012","journal-title":"J. Int. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"727530","DOI":"10.1155\/2015\/727530","article-title":"Intravenous Dexmedetomidine Provides Superior Patient Comfort and Tolerance Compared to Intravenous Midazolam in Patients Undergoing Flexible Bronchoscopy","volume":"2015","author":"Goneppanavar","year":"2015","journal-title":"Pulm. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/bja\/aer400","article-title":"Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy","volume":"108","author":"Ryu","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., G\u00f8tzsche, P.C., Ioannidis, J.P., Clarke, M., Devereaux, P.J., Kleijnen, J., and Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000100"},{"key":"ref_26","unstructured":"Higgins, J., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2022). Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022), John Wiley & Sons. Available online: www.training.cochrane.org\/handbook."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4103\/1687-7934.172743","article-title":"Propofol versus dexmedetomidine as a sole sedative for diagnostic flexible bronchoscopy: A randomized double-blind study","volume":"8","author":"Mani","year":"2015","journal-title":"Ain Shams, J. Anaesthesiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.egja.2016.07.003","article-title":"Safety and efficacy of dexmedetomidine sedation for elective fiberoptic bronchoscopy: A comparative study with propofol","volume":"32","author":"Shoukry","year":"2016","journal-title":"Egypt. J. Anaesth."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3892\/etm.2016.3274","article-title":"Dexmedetomidine-fentanyl versus propofol-fentanyl in flexible bronchoscopy: A randomized study","volume":"12","author":"Yuan","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/ijp.IJP_287_19","article-title":"Comparison of midazolam and low-dose dexmedetomidine in flexible bronchoscopy: A prospective, randomized, double-blinded study","volume":"52","author":"Magazine","year":"2020","journal-title":"Indian, J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/crj.12669","article-title":"A randomized double-blind controlled trial comparing three sedation regimens during flexible bronchoscopy: Dexmedetomidine, alfentanil and lidocaine","volume":"12","author":"Riachy","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_32","first-page":"14","article-title":"Comparing the hemodynamic effects of nebulized dexmedetomidine and nebulized lidocaine in children undergoing fiberoptic bronchoscopy","volume":"27","author":"Shafa","year":"2019","journal-title":"J. Zanjan Univ. Med. Sci. Health Serv."},{"key":"ref_33","first-page":"480","article-title":"Bronchial thermoplasty: A novel treatment for severe asthma requiring monitored anesthesia care","volume":"79","author":"Lee","year":"2011","journal-title":"AANA J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2044.2009.06226.x","article-title":"A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreoptic nasotracheal intubation","volume":"65","author":"Tsai","year":"2010","journal-title":"Anaesthesia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.2009.56","article-title":"Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial","volume":"301","author":"Riker","year":"2009","journal-title":"JAMA"},{"key":"ref_36","first-page":"Cd009798","article-title":"Dexmedetomidine for the management of awake fibreoptic intubation","volume":"2014","author":"He","year":"2014","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1607\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:39:13Z","timestamp":1760121553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12041607"],"URL":"https:\/\/doi.org\/10.3390\/jcm12041607","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}