{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:09:24Z","timestamp":1789063764688,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: The aim of this study is to describe visual outcomes and epithelial remodeling following the implantation of asymmetric intracorneal ring segments (ICRSs) of variable thickness and base width for the management of duck-type keratoconus. Methods: A prospective observational study of patients with duck-type keratoconus was conducted. All patients received one ICRS AJL PRO + implant (AJL Ophthalmic). We analyzed demographic and clinical data, anterior segment optical coherence tomography (AS-OCT) data and Scheimpflug camera images obtained with a Placido disc MS-39 (CSO, Firenze, Italy) one and six months after surgery to determine keratometric and aberrometric outcomes and epithelial remodeling. Results: We studied 33 keratoconic eyes. ICRS implantation significantly improved both corrected distance visual acuity (CDVA) and uncorrected distance visual acuity at six months, as assessed with the logMAR (minimum angle of resolution) system, from 0.32 \u00b1 0.19 to 0.12 \u00b1 0.12 (p &lt; 0.001) and from 0.75 \u00b1 0.38 to 0.37 \u00b1 0.24 (p &lt; 0.001), respectively. Overall, 87% of implanted eyes gained \u2265 1 line of CDVA, and 3% of patients (n = 1) lost one line of CDVA; 55% of eyes attained a manifest refraction spherical equivalent between +1.50 and \u22121.50 D. Epithelial remodeling was greater at the wider and thicker end (+11.33 \u00b5m \u00b1 12.95; p &lt; 0.001 relative to the initial value) than at the narrower and thinner end (+2.24 \u00b5m \u00b1 5.67; p = 0.01). Coma aberration was significantly reduced from 1.62 \u00b1 0.81 \u00b5m to 0.99 \u00b1 0.59 \u00b5m (p &lt; 0.001). Conclusions: AJL-PRO + ICRS implantation for duck-type keratoconus improves refractive, topographic, aberrometric and visual parameters and induces progressive epithelial thickening along the segment.<\/jats:p>","DOI":"10.3390\/jcm12041673","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T02:56:02Z","timestamp":1676861762000},"page":"1673","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Asymmetric Intrastromal Corneal Ring Segments with Progressive Base Width and Thickness for Keratoconus: Evaluation of Efficacy and Analysis of Epithelial Remodeling"],"prefix":"10.3390","volume":"12","author":[{"given":"Abdelmajid","family":"Benlarbi","sequence":"first","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiene","family":"Kallel","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementine","family":"David","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Barugel","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Hays","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Goemaere","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane","family":"Cuyaubere","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Borderie","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Borderie","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacim","family":"Bouheraoua","sequence":"additional","affiliation":[{"name":"CHNO des Quinze-Vingts, IHU ForeSight, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012 Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Rabinowitz","year":"1998","journal-title":"Surv. 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