{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:33Z","timestamp":1787028633889,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81870905"],"award-info":[{"award-number":["81870905"]}]},{"name":"National Natural Science Foundation of China","award":["U20A20358"],"award-info":[{"award-number":["U20A20358"]}]},{"name":"National Natural Science Foundation of China","award":["2020-1-2041"],"award-info":[{"award-number":["2020-1-2041"]}]},{"name":"National Natural Science Foundation of China","award":["2019-I2M-5-02"],"award-info":[{"award-number":["2019-I2M-5-02"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["81870905"],"award-info":[{"award-number":["81870905"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["U20A20358"],"award-info":[{"award-number":["U20A20358"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2020-1-2041"],"award-info":[{"award-number":["2020-1-2041"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2019-I2M-5-02"],"award-info":[{"award-number":["2019-I2M-5-02"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["81870905"],"award-info":[{"award-number":["81870905"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["U20A20358"],"award-info":[{"award-number":["U20A20358"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2020-1-2041"],"award-info":[{"award-number":["2020-1-2041"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-02"],"award-info":[{"award-number":["2019-I2M-5-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Elevated levels of high-sensitivity C-reactive protein (hsCRP) were associated with an increased risk of recurrent stroke. However, it is still unknown whether the predictive value of hsCRP differed according to the severity of cerebrovascular disease. We used the cohort of the prospective multicenter cohort study of the Third China National Stroke Registry (CNSR-III), in which 10,765 consecutive patients with acute ischemic stroke or transient ischemic attack (TIA) had hsCRP levels measured. Patients were classified into minor stroke, or TIA, and non-minor stroke. The primary outcome was a new stroke within 1 year. Cox proportional hazards models were used to assess the association of hsCRP and its outcome. Elevated levels of hsCRP were associated with an increased risk of recurrent stroke in minor stroke or TIA patients, irrespective of using a National Institutes of Health Stroke Scale (NIHSS) score of \u22643 (the highest quartile vs. the lowest quartile: adjusted hazard ratio, 1.48; 95% CI, 1.12\u20131.97; p = 0.007) or \u22645 (the highest quartile vs. the lowest quartile: adjusted hazard ratio, 1.45; 95% CI, 1.15\u20131.84; p = 0.002) to define minor stroke. Such association was more apparent in the large-artery atherosclerosis subtype. However, for the patients with non-minor stroke, the association of hsCRP with recurrent stroke disappeared.<\/jats:p>","DOI":"10.3390\/jcm12041676","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:29:06Z","timestamp":1676863746000},"page":"1676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Predictive Role of hsCRP in Recurrent Stroke Differed According to Severity of Cerebrovascular Disease: Analysis from a Prospective Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Jiejie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100070, China"},{"name":"Clinical Center for Precision Medicine in Stroke, Capital Medical University, Beijing 100070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1212\/01.WNL.0000110311.09970.83","article-title":"Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies","volume":"62","author":"Lovett","year":"2004","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/01.STR.0000158917.59233.b7","article-title":"Incidence and Short-Term Prognosis of Transient 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