{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:35Z","timestamp":1791295715259,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"state assignment of Ministry of Health: \u201cThe role of energy metabolism and immune defense disorders in the development of various forms of endometriosis, the development of personalized therapy and the forecast of its effectiveness in the early reproductive period (from menarche to 18 years)\u201d","award":["121032500126-3"],"award-info":[{"award-number":["121032500126-3"]}]},{"name":"state assignment of Ministry of Health: \u201cThe role of energy metabolism and immune defense disorders in the development of various forms of endometriosis, the development of personalized therapy and the forecast of its effectiveness in the early reproductive period (from menarche to 18 years)\u201d","award":["030907-2-074"],"award-info":[{"award-number":["030907-2-074"]}]},{"name":"RUDN University Scientific projects grant system","award":["121032500126-3"],"award-info":[{"award-number":["121032500126-3"]}]},{"name":"RUDN University Scientific projects grant system","award":["030907-2-074"],"award-info":[{"award-number":["030907-2-074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The early diagnosis of endometriosis in adolescents is not developed. Objective: We aim to conduct clinical, imaging, laparoscopic and histological analyses of peritoneal endometriosis (PE) in adolescents in order to improve early diagnosis. Methods: In total, 134 girls (from menarche to 17 years old) were included in a case\u2013control study: 90 with laparoscopically (LS) confirmed PE, 44 healthy controls underwent full examination and LS was analyzed in the PE group. Results: Patients with PE were characterized with heredity for endometriosis, persistent dysmenorrhea, decreased daily activity, gastrointestinal symptoms, higher LH, estradiol, prolactin and Ca-125 (&lt;0.05 for each). Ultrasound detected PE in 3.3% and MRI in 78.9%. The most essential MRI signs are as follows: hypointense foci, the heterogeneity of the pelvic tissue (paraovarian, parametrial and rectouterine pouch) and sacro-uterine ligaments lesions (&lt;0.05 for each). Adolescents with PE mostly exhibit initial rASRM stages. Red implants correlated with the rASRM score, and sheer implants correlated with pain (VAS score) (&lt;0.05). In 32.2%, foci consisted of fibrous, adipose and muscle tissue; black lesions were more likely to be histologically verified (0.001). Conclusion: Adolescents exhibit mostly initial PE stages, which are associated with greater pain. Persistent dysmenorrhea and detected MRI parameters predict the laparoscopic confirmation of initial PE in adolescents in 84.3% (OR 15.4; &lt;0.01), justifying the early surgical diagnostics and shortening the time delay and suffering of the young patients.<\/jats:p>","DOI":"10.3390\/jcm12041678","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:56:07Z","timestamp":1676865367000},"page":"1678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-307X","authenticated-orcid":false,"given":"Elena P.","family":"Khashchenko","sequence":"first","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Uvarova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department for Obstetrics, Gynecology, Perinatology and Reproduction, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-5764","authenticated-orcid":false,"given":"Timur Kh.","family":"Fatkhudinov","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department of Histology, Cytology and Embryology, Peoples\u2019 Friendship University of Russia (RUDN University), 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir D.","family":"Chuprynin","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-5209","authenticated-orcid":false,"given":"Aleksandra V.","family":"Asaturova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Kulabukhova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-6201","authenticated-orcid":false,"given":"Mikhail Yu.","family":"Vysokikh","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"A.N. Belozersky Research Institute of Physico-Chemical Biology MSU, Leninskye Gory, House 1, Building 40, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvina Z.","family":"Allakhverdieva","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Moscow State University Named after M.V. Lomonosov, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria N.","family":"Alekseeva","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Moscow State University Named after M.V. Lomonosov, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila V.","family":"Adamyan","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennady T.","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department for Obstetrics, Gynecology, Perinatology and Reproduction, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"MK, L., Tsarna, E., Eleftheriades, A., Arapaki, A., Toutoudaki, K., and Christopoulos, P. (2022). 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