{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:48:33Z","timestamp":1787856513718,"version":"build-2784847793"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital Development Special Program of Beijing Hospital Authority, China","award":["2018-1-2171"],"award-info":[{"award-number":["2018-1-2171"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute respiratory failure (ARF) remains the most common diagnosis for intensive care unit (ICU) admission in acquired immunodeficiency syndrome (AIDS) patients. Methods: We conducted a single-center, prospective, open-labeled, randomized controlled trial at the ICU, Beijing Ditan Hospital, China. AIDS patients with ARF were enrolled and randomly assigned in a 1:1 ratio to receive either high-flow nasal cannula (HFNC) oxygen therapy or non-invasive ventilation (NIV) immediately after randomization. The primary outcome was the need for endotracheal intubation on day 28. Results: 120 AIDS patients were enrolled and 56 patients in the HFNC group and 57 patients in the NIV group after secondary exclusion. Pneumocystis pneumonia (PCP) was the main etiology for ARF (94.7%). The intubation rates on day 28 were similar to HFNC and NIV (28.6% vs. 35.1%, p = 0.457). Kaplan\u2013Meier curves showed no statistical difference in cumulative intubation rates between the two groups (log-rank test 0.401, p = 0.527). The number of airway care interventions in the HFNC group was fewer than in the NIV group (6 (5\u20137) vs. 8 (6\u20139), p &lt; 0.001). The rate of intolerance in the HFNC group was lower than in the NIV group (1.8% vs. 14.0%, p = 0.032). The VAS scores of device discomfort in the HFNC group were lower than that in the NIV group at 2 h (4 (4\u20135) vs. 5 (4\u20137), p = 0.042) and at 24 h (4 (3\u20134) vs. 4 (3\u20136), p = 0.036). The respiratory rate in the HFNC group was lower than that in the NIV group at 24 h (25 \u00b1 4\/min vs. 27 \u00b1 5\/min, p = 0.041). Conclusions: Among AIDS patients with ARF, there was no statistical significance of the intubation rate between HFNC and NIV. HFNC had better tolerance and device comfort, fewer airway care interventions, and a lower respiratory rate than NIV. Clinical Trial Number: Chictr.org (ChiCTR1900022241).<\/jats:p>","DOI":"10.3390\/jcm12041679","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:29:06Z","timestamp":1676863746000},"page":"1679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High-Flow Nasal Cannula Oxygen Therapy versus Non-Invasive Ventilation in AIDS Patients with Acute Respiratory Failure: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-1351","authenticated-orcid":false,"given":"Jingjing","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuansheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0140-6736(97)10291-4","article-title":"Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease","volume":"351","author":"Li","year":"1998","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338","author":"Palella","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/0956462418805606","article-title":"The use of extracorporeal membrane oxygenation in HIV-positive patients with severe respiratory failure: A retrospective observational case series","volume":"30","author":"Collett","year":"2019","journal-title":"Int. J. STD AIDS"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"732421","DOI":"10.1155\/2013\/732421","article-title":"Etiology and Outcome of Patients with HIV Infection and Respiratory Failure Admitted to the Intensive Care Unit","volume":"2013","author":"Orsini","year":"2013","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1007\/s00134-009-1559-4","article-title":"Etiologies and outcome of acute respiratory failure in HIV-infected patients","volume":"35","author":"Barbier","year":"2009","journal-title":"Intensive Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"R202","DOI":"10.1186\/cc10419","article-title":"Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: Etiology and prognostic factors","volume":"15","author":"Chiang","year":"2011","journal-title":"Crit. Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0885066610387996","article-title":"The changing epidemiology of HIV-infected patients in the intensive care unit","volume":"26","author":"Pisani","year":"2011","journal-title":"J. Intensive Care Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wang, T., Zhang, L., Luo, K., He, J., Ma, Y., Li, Z., Zhao, N., Xu, Q., Li, Y., and Yu, X. (2016). Noninvasive versus invasive mechanical ventilation for immunocompromised patients with acute respiratory failure: A systematic review and meta-analysis. BMC Pulm. Med., 16.","DOI":"10.1186\/s12890-016-0289-y"},{"key":"ref_9","first-page":"424","article-title":"Clinical practice guideline: Non-invasive mechanical ventilation as treatment of acute respiratory failure","volume":"105","author":"Kuhlen","year":"2008","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E195","DOI":"10.1503\/cmaj.100071","article-title":"Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting","volume":"183","author":"Keenan","year":"2011","journal-title":"CMAJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4187\/respcare.01268","article-title":"A randomized trial of noninvasive positive end expiratory pressure in patients with acquired immune deficiency syndrome and hypoxemic respiratory failure","volume":"57","author":"Anjos","year":"2012","journal-title":"Respir. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1111\/ajt.16053","article-title":"Analysis of the clinical effect of noninvasive mechanical ventilation in AIDS patients complicated with pneumonia","volume":"13","author":"Liu","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa1503326","article-title":"High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure","volume":"372","author":"Frat","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1186\/s13054-020-03409-0","article-title":"High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: A multicenter non-inferiority randomized trial","volume":"24","author":"Cortegiani","year":"2020","journal-title":"Crit. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s13054-020-03214-9","article-title":"High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: A multicenter, randomized controlled trial","volume":"24","author":"Tan","year":"2020","journal-title":"Crit. Care"},{"key":"ref_16","first-page":"1077","article-title":"Nasal highflow improves ventilation in patients with COPD","volume":"11","author":"Wirtz","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4187\/respcare.06502","article-title":"Neurally-Adjusted Ventilatory Assist for Noninvasive Ventilation via a Helmet in Subjects with COPD Exacerbation: A Physiologic Study","volume":"64","author":"Longhini","year":"2019","journal-title":"Respir. Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13613-016-0151-7","article-title":"High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: An observational cohort study","volume":"6","author":"Coudroy","year":"2016","journal-title":"Ann. Intensive Care"},{"key":"ref_19","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","author":"Castro","year":"1992","journal-title":"MMWR Recomm. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: A severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1097\/00003246-200208000-00016","article-title":"Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome","volume":"30","author":"Schoenfeld","year":"2002","journal-title":"Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2012.87802","article-title":"Reporting of noninferiority and equivalence randomized trials: Extension of the CONSORT 2010 statement","volume":"308","author":"Piaggio","year":"2012","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.4187\/respcare.05962","article-title":"The Impact of High-Flow Nasal Oxygen in the Immunocompromised Critically Ill: A Systematic Review and Meta-Analysis","volume":"63","author":"Sklar","year":"2018","journal-title":"Respir. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jcrc.2018.12.015","article-title":"High flow nasal therapy in immunocompromised patients with acute respiratory failure: A systematic review and meta-analysis","volume":"50","author":"Cortegiani","year":"2019","journal-title":"J. Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4187\/respcare.03075","article-title":"Sequential application of oxygen therapy via high-flow nasal cannula and noninvasive ventilation in acute respiratory failure: An observational pilot study","volume":"60","author":"Frat","year":"2015","journal-title":"Respir. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S2213-2600(22)00096-0","article-title":"High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: A randomised controlled trial","volume":"10","author":"Coudroy","year":"2022","journal-title":"Lancet Respir. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1001\/jama.2018.14282","article-title":"Effect of High-Flow Nasal Oxygen vs. Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial","volume":"320","author":"Azoulay","year":"2018","journal-title":"JAMA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13054-015-1097-0","article-title":"The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: A multicenter randomized trial","volume":"19","author":"Lemiale","year":"2015","journal-title":"Crit. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00134-002-1395-2","article-title":"Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia","volume":"28","author":"Confalonieri","year":"2002","journal-title":"Intensive Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/jama.2015.12402","article-title":"Effect of Noninvasive Ventilation vs. Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure: A Randomized Clinical Trial","volume":"314","author":"Lemiale","year":"2015","journal-title":"JAMA"},{"key":"ref_32","first-page":"270","article-title":"Factors affecting oxygen delivery with bi-level positive airway pressure","volume":"49","author":"Schwartz","year":"2004","journal-title":"Respir. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00134-015-3693-5","article-title":"Failure of high-flow nasal cannula therapy may delay intubation and increase mortality","volume":"41","author":"Kang","year":"2015","journal-title":"Intensive Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3904\/kjim.2016.31.1.82","article-title":"Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure","volume":"31","author":"Yoo","year":"2016","journal-title":"Korean J. Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40560-015-0084-5","article-title":"High-flow nasal cannula oxygen therapy in adults","volume":"3","author":"Nishimura","year":"2015","journal-title":"J. Intensive Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.rmed.2016.11.004","article-title":"High flow nasal cannula versus conventional oxygen therapy and non-invasive ventilation in adults with acute hypoxemic respiratory failure: A systematic review","volume":"121","author":"Lee","year":"2016","journal-title":"Respir. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.4187\/respcare.01681","article-title":"Heated and humidified high-flow oxygen therapy reduces discomfort during hypoxemic respiratory failure","volume":"57","author":"Cuquemelle","year":"2012","journal-title":"Respir. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2147\/COPD.S206567","article-title":"High flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: An observational cohort study","volume":"14","author":"Sun","year":"2019","journal-title":"Int. J. Chron. Obstruct. Pulmon. 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