{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:07:17Z","timestamp":1784542037186,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acute lung injury (ALI) is a disease, with no effective treatment, which might result in death. Formations of excessive inflammation and oxidative stress are responsible for the pathophysiology of ALI. Nebivolol (NBL), a third-generation selective \u03b21 adrenoceptor antagonist, has protective pharmacological properties, such as anti-inflammatory, anti-apoptotic, and antioxidant functions. Consequently, we sought to assess the efficacy of NBL on a lipopolysaccharide (LPS)-induced ALI model via intercellular adhesion molecule-1 (ICAM-1) expression and the tissue inhibitor of metalloproteinases-1 (TIMP-1)\/matrix metalloproteinases-2 (MMP-2) signaling. Thirty-two rats were split into four categories: control, LPS (5 mg\/kg, intraperitoneally [IP], single dose), LPS (5 mg\/kg, IP, one dosage 30 min after last NBL treatment), + NBL (10 mg\/kg oral gavage for three days), and NBL (10 mg\/kg oral gavage for three days). Six hours after the administration of LPS, the lung tissues of the rats were removed for histopathological, biochemical, gene expression, and immunohistochemical analyses. Oxidative stress markers such as total oxidant status and oxidative stress index levels, leukocyte transendothelial migration markers such as MMP-2, TIMP-1, and ICAM-1 expressions in the case of inflammation, and caspase-3 as an apoptotic marker, significantly increased in the LPS group. NBL therapy reversed all these changes. The results of this study suggest that NBL has utility as a potential therapeutic agent to dampen inflammation in other lung and tissue injury models<\/jats:p>","DOI":"10.3390\/jcm12051721","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T01:39:47Z","timestamp":1677029987000},"page":"1721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The \u03b21 Adrenergic Blocker Nebivolol Ameliorates Development of Endotoxic Acute Lung Injury"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-168X","authenticated-orcid":false,"given":"Esra","family":"Nurlu Temel","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Savran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6835-4436","authenticated-orcid":false,"given":"Yalc\u0131n","family":"Erzurumlu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Suleyman Demirel University, 32260 Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursel","family":"Hasseyid","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil Ibrahim","family":"Buyukbayram","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozde","family":"Okuyucu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, 15030 Burdur, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-9365","authenticated-orcid":false,"given":"Mehmet Abdulkadir","family":"Sevuk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, 32260 Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, 15030 Burdur, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3731-2978","authenticated-orcid":false,"given":"Ayse Coskun","family":"Beyan","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, Faculty of Medicine, Dokuz Eylul University, 35220 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s10020-018-0029-2","article-title":"B-1a cells protect mice from sepsis-induced acute lung injury","volume":"24","author":"Aziz","year":"2018","journal-title":"Mol. 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