{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:49:07Z","timestamp":1771210147718,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Program Project of Zhejiang Province","award":["2021C03095"],"award-info":[{"award-number":["2021C03095"]}]},{"name":"Key Research and Development Program Project of Zhejiang Province","award":["WKJ-ZJ-2321"],"award-info":[{"award-number":["WKJ-ZJ-2321"]}]},{"name":"Zhejiang Province Major Science Program for Medicine and Health","award":["2021C03095"],"award-info":[{"award-number":["2021C03095"]}]},{"name":"Zhejiang Province Major Science Program for Medicine and Health","award":["WKJ-ZJ-2321"],"award-info":[{"award-number":["WKJ-ZJ-2321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aims to evaluate the role of endometriosis family history on the clinical manifestation and fertility performance of primary and recurrent endometriosis. In total, 312 primary and 323 recurrent endometrioma patients with a histological diagnosis were included in this study. Family history was significantly correlated with recurrent endometriosis (adjusted OR: 3.52, 95% CI: 1.09\u20139.46, p = 0.008). Patients with a family history showed a significantly higher proportion of recurrent endometriosis (75.76% vs. 49.50%), higher rASRM scores, higher incidence of severe dysmenorrhea, and severe pelvic pain than the sporadic cases. Recurrent endometrioma showed statistical increase in rASRM scores, percentage of rASRM Stage IV, dysmenorrhea, dyschezia, those undergoing semi-radical surgery or unilateral oophorosalpingectomy, postoperative medical treatment, e with a positive family history, while a decrease in the incidence of asymptomatic phenomena and those undergoing ovarian cystectomy compared to those with primary endometriosis. The naturally conceived pregnancy rate was higher in primary endometriosis compared to recurrent endometriosis. Compared to recurrent endometriosis with a negative family history, recurrent endometriosis with a positive family history had a higher incidence of severe dysmenorrhea, chronic pelvic pain, a higher spontaneous abortion rate, and a lower natural pregnancy rate. Primary endometriosis with a family history presented a higher incidence of severe dysmenorrhea than those without a family history. In conclusion, endometriosis patients with a positive family history presented a higher pain severity and lower conception probability compared to the sporadic cases. Recurrent endometriosis showed further-exacerbated clinical manifestations, more pronounced familial tendency, and lower pregnancy rates than primary endometriosis.<\/jats:p>","DOI":"10.3390\/jcm12051758","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T01:31:06Z","timestamp":1677115866000},"page":"1758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Clinical Picture and Fecundity of Primary and Recurrent Ovarian Endometriosis with Family History: A Retrospective Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Bingning","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchao","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoshuang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. 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