{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:49:13Z","timestamp":1772344153340,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S&amp;T Program of Hebei","award":["20377730D"],"award-info":[{"award-number":["20377730D"]}]},{"name":"S&amp;T Program of Hebei","award":["H2020206081"],"award-info":[{"award-number":["H2020206081"]}]},{"name":"Natural Science Foundation of Hebei Province","award":["20377730D"],"award-info":[{"award-number":["20377730D"]}]},{"name":"Natural Science Foundation of Hebei Province","award":["H2020206081"],"award-info":[{"award-number":["H2020206081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: This study aimed to investigate the effect of an additional catheter ablation (CA) procedure on the risk of post-procedure adverse events during CA combined with left atrial appendage closure (LAAC). (2) Methods: From July 2017 to February 2022, data from 361 patients with atrial fibrillation who underwent LAAC at our center were analyzed retrospectively. The adverse events were compared between CA + LAAC and LAAC-only groups. (3) Results: The incidence of device-related thrombus (DRT) and embolic events was significantly lower in the CA + LAAC group than in the LAAC-only group (p = 0.01 and 0.04, respectively). A logistic regression analysis revealed that the combined procedure served as a protective factor for DRT (OR = 0.09; 95% confidence interval: 0.01\u20130.89; p = 0.04). Based on a Cox regression analysis, the risk of embolism marginally increased in patients aged \u226565 years (HR = 7.49, 95% CI: 0.85\u201366.22 p = 0.07), whereas the combined procedure was found to be a protective factor (HR = 0.25, 95% CI: 0.07\u20130.87 p = 0.03). Further subgroup and interaction analyses revealed similar results. (4) Conclusions: The combined procedure may be associated with a lower rate of post-procedure DRT and embolization without a higher occurrence of other adverse events after LAAC. A risk-score-based prediction model was conducted, showing a good prediction performance.<\/jats:p>","DOI":"10.3390\/jcm12051824","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T03:37:20Z","timestamp":1677209840000},"page":"1824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Adverse Events between Isolated Left Atrial Appendage Closure and Combined Catheter Ablation"],"prefix":"10.3390","volume":"12","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglan","family":"Wu","sequence":"additional","affiliation":[{"name":"Second Department of Cardiac Ultrasound, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yin","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lv","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"You","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianxia","family":"Wang","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlei","family":"Zhao","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Hou","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilin","family":"Jing","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqin","family":"Xie","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hebei Institute of Cardiovascular Research, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2019.0693","article-title":"Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA 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