{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:26:58Z","timestamp":1782962818013,"version":"3.54.5"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600345"],"award-info":[{"award-number":["81600345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3332022127"],"award-info":[{"award-number":["3332022127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds for the Central Universities","award":["81600345"],"award-info":[{"award-number":["81600345"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["3332022127"],"award-info":[{"award-number":["3332022127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Although a growing number of studies have attempted to uncover the relationship between plasma lipids and the risk of aortic aneurysm (AA), it remains controversial. Meanwhile, the relationship between plasma lipids and the risk of aortic dissection (AD) has not been reported on. We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the potential relationship between genetically predicted plasma levels of lipids and the risk of AA and AD. Summary data on the relationship between genetic variants and plasma lipids were obtained from the UK Biobank and Global Lipids Genetics Consortium studies, and data on the association between genetic variants and AA or AD were taken from the FinnGen consortium study. Inverse-variance weighted (IVW) and four other MR analysis methods were used to evaluate effect estimates. Results showed that genetically predicted plasma levels of low-density lipoprotein cholesterol, total cholesterol, or triglycerides were positively correlated with the risk of AA, and plasma levels of high-density lipoprotein cholesterol were negatively correlated with the risk of AA. However, no causal relationship was found between elevated lipid levels and the risk of AD. Our study revealed a causal relationship between plasma lipids and the risk of AA, while plasma lipids had no effect on the risk of AD.<\/jats:p>","DOI":"10.3390\/jcm12051991","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T01:43:00Z","timestamp":1677807780000},"page":"1991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic Association between the Levels of Plasma Lipids and the Risk of Aortic Aneurysm and Aortic Dissection: A Two-Sample Mendelian Randomization Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-297X","authenticated-orcid":false,"given":"Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1161\/ATVBAHA.119.312000","article-title":"Updates of Recent Aortic Aneurysm Research","volume":"39","author":"Davis","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: Aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1161\/HYPERTENSIONAHA.118.11851","article-title":"Sex Differences in Thoracic Aortic Aneurysm Growth","volume":"73","author":"Boczar","year":"2019","journal-title":"Hypertension"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gheart.2013.12.010","article-title":"Global and Regional Burden of Aortic Dissection and Aneurysms: Mortality Trends in 21 World Regions, 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"Glob. Heart"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Carrel, T., Sundt, T.M., von Kodolitsch, Y., and Czerny, M. (2023). Acute Aortic Dissection. Lancet, online ahead of print.","DOI":"10.1016\/S0140-6736(22)01970-5"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41569-021-00541-4","article-title":"Global Epidemiology of Dyslipidaemias","volume":"18","author":"Pirillo","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_8","unstructured":"Task Force Members, ESC Committee for Practice Guidelines (CPG), and ESC National Cardiac Societies (2019). 2019 ESC\/EAS Guidelines for the Management of Dyslipidaemias: Lipid Modification to Reduce Cardiovascular Risk. Atherosclerosis, 290, 140\u2013205."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jvs.2005.01.002","article-title":"Risk factors associated with abdominal aortic aneurysm: A population-based study with historical and current data","volume":"41","author":"Wanhainen","year":"2005","journal-title":"J. Vasc. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.108.817619","article-title":"Risk factors for abdominal aortic aneurysms: A 7-year prospective study: The Tromso Study, 1994\u20132001","volume":"119","author":"Forsdahl","year":"2009","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.annepidem.2007.02.004","article-title":"Traditional and novel risk factors for clinically diagnosed abdominal aortic aneurysm: The Kaiser multiphasic health checkup cohort study","volume":"17","author":"Iribarren","year":"2007","journal-title":"Ann. Epidemiol."},{"key":"ref_12","first-page":"371","article-title":"Serum high-density and low-density lipoprotein cholesterol is associated with abdominal aortic aneurysm presence: A systematic review and meta-analysis","volume":"29","author":"Takagi","year":"2010","journal-title":"Int. Angiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.avsg.2022.03.027","article-title":"The Correlation between the Inflammatory Effects of Activated Macrophages in Atherosclerosis and Aortic Dissection","volume":"85","author":"Liu","year":"2022","journal-title":"Ann. Vasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lin, Y.J., Lin, J.L., Peng, Y.C., Li, S.L., and Chen, L.W. (2022). TG\/HDL-C ratio predicts in-hospital mortality in patients with acute type A aortic dissection. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02793-5"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"a040501","DOI":"10.1101\/cshperspect.a040501","article-title":"Mendelian Randomization: Concepts and Scope","volume":"12","author":"Richmond","year":"2022","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1093\/eurheartj\/ehac394","article-title":"From the Garden to the Clinic: How Mendelian Randomization Is Shaping up Atherosclerotic Cardiovascular Disease Prevention Strategies","volume":"43","author":"Arsenault","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1001\/jamacardio.2017.4293","article-title":"Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis","volume":"3","author":"Harrison","year":"2018","journal-title":"JAMA Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chen, Y., Huang, M., Xuan, Y., Li, K., Xu, X., Wang, L., Sun, Y., Xiao, L., Xu, P., and Kong, W. (2021). Association between Lipid Levels and Risk for Different Types of Aneurysms: A Mendelian Randomization Study. J. Pers. Med., 11.","DOI":"10.3390\/jpm11111171"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Weng, L.C., Roetker, N.S., Lutsey, P.L., Alonso, A., Guan, W., Pankow, J.S., Folsom, A.R., Steffen, L.M., Pankratz, N., and Tang, W. (2018). Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195719"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., and Landray, M. (2015). Uk Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001779"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.amjcard.2009.12.076","article-title":"Association between serum lipoproteins and abdominal aortic aneurysm","volume":"105","author":"Golledge","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2711","DOI":"10.1161\/CIRCGEN.119.002711","article-title":"Genetic Determinants of Lipids and Cardiovascular Disease Outcomes: A Wide-Angled Mendelian Randomization Investigation","volume":"12","author":"Allara","year":"2019","journal-title":"Circ. Genom. Precis. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4065\/79.2.176","article-title":"Acute aortic dissection: Population-based incidence compared with degenerative aortic aneurysm rupture","volume":"79","author":"Clouse","year":"2004","journal-title":"Mayo Clin. Proc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.12669\/pjms.324.10124","article-title":"Impact of admission serum total cholesterol level on in-hospital mortality in patients with acute aortic dissection","volume":"32","author":"Liu","year":"2016","journal-title":"Pak. J. Med. Sci."},{"key":"ref_26","first-page":"5419846","article-title":"Triglyceride\/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection","volume":"2020","author":"Zhou","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e024248","DOI":"10.1161\/JAHA.121.024248","article-title":"Low-Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific","volume":"11","author":"Cupido","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"107592","DOI":"10.1016\/j.pharmthera.2020.107592","article-title":"Lipid lowering therapy in cardiovascular disease: From myth to molecular reality","volume":"213","author":"Mourikis","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2020.07.019","article-title":"Lipoproteins and lipids in cardiovascular disease: From mechanistic insights to therapeutic targeting","volume":"159","author":"Soppert","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1136\/heartjnl-2020-318760","article-title":"Intensive low-density lipoprotein cholesterol lowering in cardiovascular disease prevention: Opportunities and challenges","volume":"107","author":"Packard","year":"2021","journal-title":"Heart"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.2015.15629","article-title":"Statins for Prevention of Cardiovascular Disease in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"316","author":"Chou","year":"2016","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/FJC.0000000000000653","article-title":"Relationships of Statin Therapy and Hyperlipidemia with the Incidence, Rupture, Postrepair Mortality, and All-Cause Mortality of Abdominal Aortic Aneurysm and Cerebral Aneurysm: A Meta-analysis and Systematic Review","volume":"73","author":"Cheng","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1161\/CIRCRESAHA.118.311227","article-title":"PCSK9: From Basic Science Discoveries to Clinical Trials","volume":"122","author":"Shapiro","year":"2018","journal-title":"Circ. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41588-018-0222-9","article-title":"Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program","volume":"50","author":"Klarin","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1161\/ATVBAHA.116.307613","article-title":"Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-Induced Abdominal Aortic Aneurysms in C57BL\/6 Mice-Brief Report","volume":"36","author":"Lu","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1016\/j.jacc.2019.08.1024","article-title":"Long-Term Efficacy and Safety of Evolocumab in Patients with Hypercholesterolemia","volume":"74","author":"Koren","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1501031","article-title":"Efficacy and safety of alirocumab in reducing lipids and cardiovascular events","volume":"372","author":"Robinson","year":"2015","journal-title":"N. Engl. J. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/5\/1991\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:46:10Z","timestamp":1760121970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/5\/1991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jcm12051991"],"URL":"https:\/\/doi.org\/10.3390\/jcm12051991","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]}}}