{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:49:35Z","timestamp":1792712975528,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The aim of this study is to present the first United Arab Emirates pulmonary hypertension registry of patients\u2019 clinical characteristics, hemodynamic parameters and treatment outcomes. Method: This is a retrospective study describing all the adult patients who underwent a right heart catheterization for evaluation of pulmonary hypertension (PH) between January 2015 and December 2021 in a tertiary referral center in Abu Dhabi, United Arab Emirates. Results: A total of 164 consecutive patients were diagnosed with PH during the five years of the study. Eighty-three patients (50.6%) were World Symposium PH Group 1-PH; nineteen patients (11.6%) were Group 2-PH due to left heart disease; twenty-three patients (14.0%) were Group 3-PH due to chronic lung disease; thirty-four patients (20.7%) were Group 4-PH due to chronic thromboembolic lung disease, and five patients (3.0%) were Group 5-PH. Among Group 1-PH, twenty-five (30%) had idiopathic, twenty-seven (33%) had connective tissue disease, twenty-six (31%) had congenital heart disease, and five patients (6%) had porto-pulmonary hypertension. The median follow-up was 55.6 months. Most of the patients were started on dual then sequentially escalated to triple combination therapy. The 1-, 3- and 5-year cumulative probabilities of survival for Group 1-PH were 86% (95% CI, 75\u201392%), 69% (95% CI, 54\u201380%) and 69% (95% CI, 54\u201380%). Conclusions: This is the first registry of Group 1-PH from a single tertiary referral center in the UAE. Our cohort was younger with a higher percentage of patients with congenital heart disease compared to cohorts from Western countries but similar to registries from other Asian countries. Mortality is comparable to other major registries. Adopting the new guideline recommendations and improving the availability and adherence to medications are likely to play a significant role in improving outcomes in the future.<\/jats:p>","DOI":"10.3390\/jcm12051996","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T01:43:00Z","timestamp":1677807780000},"page":"1996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The First Pulmonary Hypertension Registry in the United Arab Emirates (UAEPH): Clinical Characteristics, Hemodynamic Parameters with Focus on Treatment and Outcomes for Patients with Group 1-PH"],"prefix":"10.3390","volume":"12","author":[{"given":"Khaled","family":"Saleh","sequence":"first","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naureen","family":"Khan","sequence":"additional","affiliation":[{"name":"St. George\u2019s University, West Indies, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Dougherty","sequence":"additional","affiliation":[{"name":"Temple University Hospital, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govinda","family":"Bodi","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Michalickova","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiuddin","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Kerenidi","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Sadik","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-7360","authenticated-orcid":false,"given":"Jihad","family":"Mallat","sequence":"additional","affiliation":[{"name":"Critical Care Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"},{"name":"Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"},{"name":"Faculty of Medicine, Normandy University, UNICAEN, ED 497, 14032 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Farha","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Ohio, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Sabbour","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi P.O. Box 112412, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lan, N.S.H., Massam, B.D., Kulkarni, S.S., and Lang, C.C. (2018). Pulmonary Arterial Hypertension: Pathophysiology and Treatment. 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