{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:34:08Z","timestamp":1790883248266,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study aimed to assess the prevalence and course of endometriosis in adolescents with obstructive M\u00fcllerian anomalies. Methods: The study group involved 50 adolescents undergoing surgeries (median age 13.5 (range 11.1\u201318.5)) for rare obstructive malformations of the genital tract: 15 girls had anomalies associated with cryptomenorrhea and 35 were menstruating. The median follow-up period was 2.4 (ranging from 0.1 to 9.5) years. Results: We diagnosed endometriosis in 23 of the 50 subjects (46%), including 10 of the 23 patients (43.5%) with obstructed hemivagina ipsilateral renal anomaly syndrome (OHVIRAS), six of eight patients (75%) with a unicornuate uterus with a non-communicating functional horn, two of three patients (66.7%) with distal vaginal aplasia, and five of five patients (100%) with cervicovaginal aplasia. Persistent dysmenorrhea, following treatment, affected 14 of the 50 adolescents (28%), including 8 of the 17 subjects (47.1%) diagnosed with endometriosis at the time of surgical correction and six adolescents diagnosed with endometriosis during the follow-up. Conclusions: Endometriosis affects about half of young adolescents undergoing surgical treatment of obstructive M\u00fcllerian anomalies after menarche. The incidence of endometriosis is highest in girls with cervical aplasia. The risk of developing endometriosis decreases after surgical correction of obstruction but is still significant in patients with uterine anomalies.<\/jats:p>","DOI":"10.3390\/jcm12052007","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T01:43:00Z","timestamp":1677807780000},"page":"2007","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-6841","authenticated-orcid":false,"given":"Karina","family":"Kapczuk","sequence":"first","affiliation":[{"name":"Division of Gynecology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Zaj\u0105czkowska","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Clinical Hospital of Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudyna","family":"Madziar","sequence":"additional","affiliation":[{"name":"Division of Gynecology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"K\u0119dzia","sequence":"additional","affiliation":[{"name":"Division of Gynecology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2018). ACOG Committee Opinion Number 760 Dysmenorrhea and Endometriosis in the Adolescent. Obstet. Gynecol., 132, 249\u2013258.","DOI":"10.1097\/AOG.0000000000002978"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jpag.2017.09.013","article-title":"Obstructive m\u00fcllerian anomalies in menstruating adolescent girls: A report of 22 cases","volume":"31","author":"Kapczuk","year":"2018","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/GCO.0000000000000300","article-title":"Obstructive anomalies of the gynecologic tract","volume":"28","author":"Patel","year":"2016","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jpag.2012.03.002","article-title":"Adolescent endometriosis in China: A retrospective analysis of 63 cases","volume":"25","author":"Yang","year":"2012","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000292349","article-title":"Endometriosis in association with m\u00fcllerian anomalies","volume":"40","author":"Turan","year":"1995","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ejogrb.2020.01.045","article-title":"Endometriosis in adolescence: Early manifestation of the traditional disease or a unique variant?","volume":"247","author":"Tsonis","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0002-9378(86)90389-3","article-title":"Endometriosis in association with uterine anomaly","volume":"154","author":"Sanfilippo","year":"1986","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.jpag.2013.01.002","article-title":"Persistence of endometriosis after correction of an obstructed reproductive tract anomaly","volume":"26","author":"Silveira","year":"2013","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jpag.2020.06.021","article-title":"Clinical Characteristics and Postoperative Symptoms of 85 Adolescents with Endometriosis","volume":"33","author":"Song","year":"2020","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/humrep\/det098","article-title":"The ESHRE\/ESGE consensus on the classification of female genital tract congenital anomalies","volume":"28","author":"Grimbizis","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.fertnstert.2021.09.025","article-title":"ASRM m\u00fcllerian anomalies classification 2021","volume":"116","author":"Pfeifer","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"American Society for Reproductive Medicine (1997). Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil. Steril., 67, 817\u2013821.","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE Endometriosis Guideline Group. ESHRE guideline: Endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum. Reprod. Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/aogs.14419","article-title":"Surgically confirmed endometriosis in adolescents in Finland-A register-based cross-sectional cohort study","volume":"101","author":"Rasp","year":"2022","journal-title":"Acta Obstet. Et Gynecol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"653.e1","DOI":"10.1016\/j.jpurol.2021.06.023","article-title":"Multiple variants of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome - one clinical center case series and the systematic review of 734 cases","volume":"17","author":"Kudela","year":"2021","journal-title":"J. Pediatr. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jmig.2006.08.010","article-title":"Septate uterus with double cervices, unilaterally obstructed vaginal septum, and ipsilateral renal agenesis: A rare combination of m\u00fcllerian and wolffian anomalies complicated by severe endometriosis in an adolescent","volume":"14","author":"Hur","year":"2007","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.fertnstert.2014.05.025","article-title":"Endometriosis in association with Herlyn-Werner-Wunderlich syndrome","volume":"102","author":"Tong","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.fertnstert.2007.01.168","article-title":"Laparoscopically assisted uterovestibular anastomosis in patients with uterine cervix atresia and vaginal aplasia","volume":"89","author":"Fedele","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijgo.2016.02.015","article-title":"Clinical characteristics of congenital cervical atresia and associated endometriosis among 96 patients","volume":"134","author":"Song","year":"2016","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00261-020-02465-y","article-title":"M\u00fcllerian duct anomalies coincident with endometriosis: A review","volume":"45","author":"Pitot","year":"2020","journal-title":"Abdom. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00404-020-05750-9","article-title":"Coincidence of uterine malformations and endometriosis: A clinically relevant problem?","volume":"302","author":"Piriyev","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1479-828X.2010.01141.x","article-title":"Adolescent endometriosis in the Waikato region of New Zealand\u2014A comparative cohort study with a mean follow-up time of 2.6 years","volume":"50","author":"Roman","year":"2010","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/humupd\/dmt016","article-title":"Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: A systematic review","volume":"19","author":"Janssen","year":"2013","journal-title":"Hum. Reprod. Update"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/5\/2007\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:46:39Z","timestamp":1760121999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/5\/2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jcm12052007"],"URL":"https:\/\/doi.org\/10.3390\/jcm12052007","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]}}}