{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:52:34Z","timestamp":1778356354131,"version":"3.51.4"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Hospital Randers","award":["PhD grant"],"award-info":[{"award-number":["PhD grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Distal radius fractures (DRFs) in the elderly are common. Recently, the efficacy of operative treatment of displaced DRFs in patients above 65 years of age has been questioned and it has been suggested that non-operative treatment should be the gold standard. However, the complications and functional outcome of displaced vs. minimally and non-displaced DRFs in the elderly has not been evaluated yet. The aim of the present study was to compare non-operatively treated displaced DRFs vs. minimally and non-displaced DRFs in terms of complications, PROMs, grip strength and range of motion (ROM) after 2 weeks, 5 weeks, 6 months and 12 months. Methods: We used a prospective cohort study that compared patients with displaced DRFs (n = 50), i.e., &gt;10 degrees of dorsal angulation after two reduction attempts, with patients with minimally or non-displaced DRFs after reduction. Both cohorts received the same treatment of 5 weeks of dorsal plaster casting. Complications and functional outcomes (quick disabilities of the arm, shoulder and hand (QuickDASH), patient-rated wrist\/hand evaluation (PRWHE), grip strength and EQ-5D scores) were assessed after 5 weeks, 6 months and 12 months post-injury. The protocol of the VOLCON RCT and present observational study has been published (PMC6599306; clinicaltrials.gov: NCT03716661). Results: One year after 5 weeks of dorsal below-elbow casting of low-energy DRFs in patients \u2265 65 years old, we found a complication rate of 6.3% (3\/48) in minimally or non-displaced DRFs and 16.6% (7\/42) in displaced DRFs (p = 0.18). However, no statistically significant difference was observed in functional outcomes in terms of QuickDASH, pain, ROM, grip strength or EQ-5D scores. Discussion: In patients above 65 years of age, non-operative treatment, i.e., closed reduction and dorsal casting for 5 weeks, yielded similar complication rates and functional outcomes after 1 year regardless of whether the initial fracture was non-displaced\/minimally displaced or still displaced after closed reduction. While the initial closed reduction should still be attempted in order to restore the anatomy, failure to achieve the stipulated radiological criteria may not be as important as we thought in terms of complications and functional outcome.<\/jats:p>","DOI":"10.3390\/jcm12052076","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:43:35Z","timestamp":1678153415000},"page":"2076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prospective Evaluation of Two Cohorts of Non-Operatively Treated Patients with Displaced vs. Minimally and Non-Displaced Distal Radius Fractures"],"prefix":"10.3390","volume":"12","author":[{"given":"Rikke","family":"Thorninger","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Regional Hospital Randers, Skovlyvej 15, 8930 Randers, Denmark"},{"name":"Department of Clinical Medicine, HEALTH, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-1219","authenticated-orcid":false,"given":"Daniel","family":"W\u00e6ver","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Regional Hospital Randers, Skovlyvej 15, 8930 Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tj\u00f8rnild","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Regional Hospital Randers, Skovlyvej 15, 8930 Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, HEALTH, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus, Denmark"},{"name":"Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, J801, 8200 Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-2983","authenticated-orcid":false,"given":"Jan Duedal","family":"R\u00f6lfing","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, HEALTH, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus, Denmark"},{"name":"Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, J801, 8200 Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Raudasoja, L., Aspinen, S., Vastam\u00e4ki, H., Ryh\u00e4nen, J., and Hulkkonen, S. (2022). Epidemiology and Treatment of Distal Radius Fractures in Finland-a Nationwide Register Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11102851"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00198-016-3488-8","article-title":"The Epidemiology of Fractures in Denmark in 2011","volume":"27","author":"Driessen","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_3","unstructured":"Sundhedsstyrelsen (2023, February 08). National Klinisk Retningslinje for Behandling Af H\u00e5ndledsn\u00e6re Brud (Distal Radiusfraktur). Available online: https:\/\/www.sst.dk\/-\/media\/Udgivelser\/2014\/NKR-H%C3%A5ndledsn%C3%A6re-underarmsbrud\/National-klinisk-retningslinie-for-behandling-af-haandledsnaere-brud.ashx."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13018-020-01734-2","article-title":"Nonoperative Treatment Versus Volar Locking Plate Fixation for Elderly Patients with Distal Radial Fracture: A Systematic Review and Meta-Analysis","volume":"15","author":"Li","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jhsa.2015.12.008","article-title":"Safety and Efficacy of Operative Versus Nonsurgical Management of Distal Radius Fractures in Elderly Patients: A Systematic Review and Meta-Analysis","volume":"41","author":"Chen","year":"2016","journal-title":"J. Hand Surg. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/CORR.0000000000001524","article-title":"What is the relative effectiveness of the various surgical treatment options for distal radius fractures? A systematic review and network meta-analysis of randomized controlled trials","volume":"479","author":"Woolnough","year":"2021","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.2106\/JBJS.19.01442","article-title":"Volar Locked Plating Versus Closed Reduction and Casting for Acute, Displaced Distal Radial Fractures in the Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"102","author":"Stephens","year":"2020","journal-title":"J. Bone Jt. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e20.00022","DOI":"10.2106\/JBJS.RVW.20.00022","article-title":"Volar Locking Plate Fixation Versus Closed Reduction for Distal Radial Fractures in Adults: A Systematic Review and Meta-Analysis","volume":"9","author":"Lawson","year":"2021","journal-title":"JBJS Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s10195-022-00673-4","article-title":"VOLCON: A Randomized Controlled Trial Investigating Complications and Functional Outcome of Volar Plating vs. Casting of Unstable Distal Radius Fractures in Patients Older than 65 Years","volume":"23","author":"Thorninger","year":"2022","journal-title":"J. Orthop. Traumatol."},{"key":"ref_10","unstructured":"American Academy of Orthopaedic Surgeons (AAOS) (2023, February 08). Management of Distal Radius Fractures Evidence-Based Clinical Practice Guideline. Available online: www.aaos.org\/drfcpg."},{"key":"ref_11","unstructured":"The British Society for Surgery of the Hand (2023, February 08). Best Practice for Management of Distal Radial Fractures. Available online: https:\/\/www.bssh.ac.uk\/_userfiles\/pages\/files\/professionals\/Radius\/Blue%20Book%20DRF%20Final%20Document.pdf."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pedersen, J., Mortensen, S.O., R\u00f6lfing, J.D., and Thorninger, R. (2019). A Protocol for a Single-Center, Single-Blinded Randomized-Controlled Trial Investigating Volar Plating Versus Conservative Treatment of Unstable Distal Radius Fractures in Patients Older Than 65 Years. BMC Musculoskelet. Disord., 20.","DOI":"10.1186\/s12891-019-2677-y"},{"key":"ref_13","first-page":"A5306","article-title":"Validation of the Danish Version of the Quick-Disabilities of Arm, Shoulder and Hand Questionnaire","volume":"63","author":"Eggers","year":"2016","journal-title":"Dan. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jhsa.2013.09.041","article-title":"Performance Characteristics of the Verbal QuickDASH","volume":"39","author":"London","year":"2014","journal-title":"J. Hand Surg. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00402-013-1767-9","article-title":"Recommendation for Measuring Clinical Outcome in Distal Radius Fractures: A Core Set of Domains for Standardized Reporting in Clinical Practice and Research","volume":"134","author":"Goldhahn","year":"2014","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2519\/jospt.2014.4893","article-title":"Minimal clinically important difference of the disabilities of the arm, shoulder and hand outcome measure (DASH) and its shortened version (QuickDASH)","volume":"44","author":"Franchignoni","year":"2014","journal-title":"J. Orthop. Sport. Phys. Ther."},{"key":"ref_17","unstructured":"Institute for Work & Health (2023, February 17). The Dash Outcome Measure\u2014Frequently Asked Questions (FAQ): What Is Considered to Be a Clinically Important Change for the Dash\/QuickDASH?. Available online: https:\/\/dash.iwh.on.ca\/faq."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1758998318807238","article-title":"Danish Version of the Patient-Rated Wrist\/Hand Evaluation Questionnaire: Translation, Cross-Cultural Adaptation, Test\u2013Retest Reliability and Construct Validity","volume":"24","author":"Hansen","year":"2019","journal-title":"Hand Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1007\/s11999-015-4376-9","article-title":"The Minimum Clinically Important Difference of the Patient-Rated Wrist Evaluation Score for Patients with Distal Radius Fractures","volume":"473","author":"Walenkamp","year":"2015","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2106\/JBJS.18.00768","article-title":"Nonoperative Treatment Compared with Volar Locking Plate Fixation for Dorsally Displaced Distal Radial Fractures in the Elderly: A Randomized Controlled Trial","volume":"101","author":"Saving","year":"2019","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2519\/jospt.1992.16.5.215","article-title":"Measurement of Grip Strength: Validity and Reliability of the Sphygmomanometer and Jamar Grip Dynamometer","volume":"16","author":"Hamilton","year":"1992","journal-title":"J. Orthop. Sport. Phys. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1007\/s11999-014-3666-y","article-title":"What Is the Minimum Clinically Important Difference in Grip Strength?","volume":"472","author":"Kim","year":"2014","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jhsg.2022.08.001","article-title":"Incidence of Carpa\u00e6 Tunnel Syndrome after Distal Radius Fracture","volume":"4","author":"Cooke","year":"2022","journal-title":"J. Hand Surg. Glob. Online"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.2106\/JBJS.J.01597","article-title":"A prospective randomized trial comparing nonoperative treatment with volar locking plate fixation for displaced and unstable distal radial fractures in patients sixty-five years of age and older","volume":"93","author":"Arora","year":"2011","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1302\/0301-620X.103B2.BJJ-2020-0192.R2","article-title":"Cast immobilization is non-inferior to volar locking plates in relation to QuickDASH after one year in patients aged 65 years and older: A randomized controlled trial of displaced distal radius fractures","volume":"103","author":"Hassellund","year":"2021","journal-title":"Bone Joint J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1001\/jamasurg.2020.5672","article-title":"Surgical plating vs closed reduction for fractures in the distal radius in older patients: A randomized clinical trial","volume":"156","author":"Lawson","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e203497","DOI":"10.1001\/jamanetworkopen.2020.3497","article-title":"Operative vs nonoperative treatment of distal radius fractures in adults: A systematic review and meta-analysis","volume":"3","author":"Ochen","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Thorninger, R., W\u00e6ver, D., Pedersen, J., Tvedegaard-Christensen, J., Tj\u00f8rnild, M., Lind, M., and R\u00f6lfing, J.D. (2021). Objective Outcome Measures Continue to Improve from 6 to 12 Months after Conservatively Treated Distal Radius Fractures in the Elderly-a Prospective Evaluation of 50 Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10091831"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zadeh, S.S.T., Moazzeni, S.S., Asgari, S., Mirbolouk, M., Azizi, F., and Hadaegh, F. (2022). Association between Wrist Circumference and Risk of Any Fracture in Adults: Findings from 15 Years of Follow-up in the Tehran Lipid and Glucose Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11237048"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Oh, C.H., Kim, J., Kim, J., Yoon, S., Jung, Y., Lee, H.I., Choi, J., Lee, S., and Han, S. (2022). The Association of Low Skeletal Muscle Mass with Complex Distal Radius Fracture. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195581"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Olech, J., Konieczny, G., Tomczyk, L., and Morasiewicz, P. (2021). A Randomized Trial Assessing the Muscle Strength and Range of Motion in Elderly Patients Following Distal Radius Fractures Treated with 4- and 6-Week Cast Immobilization. J. Clin. Med., 10.","DOI":"10.3390\/jcm10245774"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00590-018-2150-x","article-title":"Conservative Treatment of Distal Fractures after the Age of 65: A Review of Literature","volume":"28","author":"Bruyere","year":"2018","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/ACO.0000000000000456","article-title":"Frailty and Anesthesia","volume":"30","author":"Matot","year":"2017","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.lpm.2018.03.013","article-title":"Anesthesia and the Risk of Dementia in the Elderly","volume":"47","author":"Steinmetz","year":"2018","journal-title":"La Presse M\u00e9d."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101877","DOI":"10.1016\/j.semerg.2022.101877","article-title":"Evidence-Based Medicine Needs Patient and Public Involvement to Remain Relevant: A Proposal for a New Curriculum","volume":"49","author":"Moss","year":"2022","journal-title":"Semergen"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/5\/2076\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:49:03Z","timestamp":1760122143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/5\/2076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jcm12052076"],"URL":"https:\/\/doi.org\/10.3390\/jcm12052076","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]}}}