{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:58:56Z","timestamp":1760147936560,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Coronary artery disease (CAD) screening is usually performed before transcatheter aortic valve implantation (TAVI) by invasive coronary angiography (ICA). Computed coronary tomography angiography (CCTA) has shown good diagnostic performance for CAD screening in patients with a low probability of CAD and is systematically performed before TAVI. CCTA could be an efficient alternative to ICA for CAD screening before TAVI. We sought to investigate the diagnostic performance of CCTA in a population of unselected patients without known CAD who were candidates for TAVI. All consecutive patients referred to our center for TAVI without known CAD were enrolled. All patients underwent CCTA and ICA, which were considered the gold standard. A statistical analysis of the diagnostic performance per patient and per artery was performed. 307 consecutive patients were enrolled. CCTA was non-analyzable in 25 patients (8.9%). In the per-patient analysis, CCTA had a sensitivity of 89.6%, a specificity of 90.2%, a positive predictive value of 65.15%, and a negative predictive value of 97.7%. Only five patients were classified as false negatives on the CCTA. Despite some limitations of the study, CCTA seems reliable for CAD screening in patients without known CAD who are candidates for TAVI. By using CCTA, ICA could be avoided in patients with a CAD-RADS score \u2264 2, which represents 74.8% of patients.<\/jats:p>","DOI":"10.3390\/jcm12062285","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T06:53:32Z","timestamp":1678863212000},"page":"2285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Feasibility of Non-Invasive Coronary Artery Disease Screening with Coronary CT Angiography before Transcatheter Aortic Valve Implantation"],"prefix":"10.3390","volume":"12","author":[{"given":"J\u00e9r\u00e9my","family":"Boyer","sequence":"first","affiliation":[{"name":"D\u00e9partement de Cardiologie, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Bartoli","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHU Timone, AP-HM, 264, Rue Saint-Pierre, 13005 Marseille, France"},{"name":"CRMBM-UMR CNRS 7339, Aix-Marseille Universit\u00e9, 27, Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Deharo","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, CHU Timone, 13005 Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Inserm, Inra, C2VN, 13005 Marseille, France"},{"name":"Facult\u00e9 de M\u00e9decine, Aix-Marseille Universit\u00e9, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Vaillier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Ferrara","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Antoine","family":"Barral","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHU Timone, AP-HM, 264, Rue Saint-Pierre, 13005 Marseille, France"},{"name":"CRMBM-UMR CNRS 7339, Aix-Marseille Universit\u00e9, 27, Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Jaussaud","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardiaque, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Morera","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardiaque, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliz\u00e9e","family":"Porto","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardiaque, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-7184","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Collart","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Aix-Marseille Universit\u00e9, 13005 Marseille, France"},{"name":"Service de Chirurgie Cardiaque, CHU Timone, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Jacquier","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHU Timone, AP-HM, 264, Rue Saint-Pierre, 13005 Marseille, France"},{"name":"CRMBM-UMR CNRS 7339, Aix-Marseille Universit\u00e9, 27, Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cuisset","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, CHU Timone, 13005 Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Inserm, Inra, C2VN, 13005 Marseille, France"},{"name":"Facult\u00e9 de M\u00e9decine, Aix-Marseille Universit\u00e9, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients","volume":"364","author":"Smith","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1056\/NEJMoa1400590","article-title":"Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis","volume":"370","author":"Adams","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1093\/eurheartj\/ehy267","article-title":"The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: A meta-analysis focused on post-test disease probability","volume":"39","author":"Knuuti","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.jacc.2008.07.031","article-title":"Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease: Results From the Prospective Multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) Trial","volume":"52","author":"Budoff","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mowatt, G. (2008). Systematic review of the clinical effectiveness and cost-effectiveness of 64-slice or higher computed tomography angiography as an alternative to invasive coronary angiography in the investigation of coronary artery disease. Health Technol. Assess., 12.","DOI":"10.3310\/hta12170"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"19942","DOI":"10.1038\/s41598-019-56519-3","article-title":"Diagnostic accuracy of computed tomography angiography for the exclusion of coronary artery disease in candidates for transcatheter aortic valve implantation","volume":"9","author":"Strong","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ahj.2014.04.022","article-title":"Diagnostic accuracy of multidetector computed tomography coronary angiography in 325 consecutive patients referred for transcatheter aortic valve replacement","volume":"168","author":"Andreini","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s12471-018-1149-6","article-title":"CTCA for detection of significant coronary artery disease in routine TAVI work-up: A systematic review and meta-analysis","volume":"26","author":"Vendrik","year":"2018","journal-title":"Neth. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1007\/s00330-022-08603-y","article-title":"Diagnostic accuracy of coronary computed tomography angiography for the evaluation of obstructive coronary artery disease in patients referred for transcatheter aortic valve implantation: A systematic review and meta-analysis","volume":"32","author":"Gatti","year":"2022","journal-title":"Eur. Radiol."},{"key":"ref_12","unstructured":"(2022, December 02). Balloon-Expandable versus Self-Expanding Transcatheter Aortic Valve Replacement. Available online: https:\/\/www.ahajournals.org\/doi\/epdf\/10.1161\/CIRCULATIONAHA.119.043785."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.21037\/cdt.2017.06.07","article-title":"Advances in cardiac CT contrast injection and acquisition protocols","volume":"7","author":"Scholtz","year":"2017","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.jcmg.2022.07.002","article-title":"CAD-RADSTM 2.0\u20142022 Coronary Artery Disease-Reporting and Data System","volume":"15","author":"Cury","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.15829\/1560-4071-2020-2-3757","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC)","volume":"25","author":"Knuuti","year":"2020","journal-title":"Russ. J. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cjca.2021.10.002","article-title":"A Computed Tomography Protocol to Evaluate Coronary Artery Disease Before Transcatheter Aortic Valve Replacement","volume":"38","author":"Chavarria","year":"2022","journal-title":"Can. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcct.2014.11.008","article-title":"Coronary CT angiography for the detection of coronary artery stenosis in patients referred for transcatheter aortic valve replacement","volume":"9","author":"Hamdan","year":"2015","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients","volume":"380","author":"Popma","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jcmg.2017.08.026","article-title":"The Coronary Artery Disease-Reporting and Data System (CAD-RADS): Prognostic and Clinical Implications Associated with standardized coronary computed tomography angiography reporting","volume":"11","author":"Xie","year":"2018","journal-title":"J. Am. Coll. Cardiol. Img."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1805971","article-title":"Coronary CT Angiography and 5-Year Risk of Myocardial Infarction (SCOT-HEART)","volume":"379","author":"Newby","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gohmann, R.F., Lauten, P., Seitz, P., Krieghoff, C., L\u00fccke, C., Gottschling, S., Mende, M., Wei\u00df, S., Wilde, J., and Kiefer, P. (2020). Combined Coronary CT-Angiography and TAVI-Planning: A Contrast-Neutral Routine Approach for Ruling-Out Significant Coronary Artery Disease. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061623"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s12265-021-10099-8","article-title":"Computed Tomography Angiography for the Diagnosis of Coronary Artery Disease Among Patients Undergoing Transcatheter Aortic Valve Implantation","volume":"14","author":"Meier","year":"2021","journal-title":"J. Cardiovasc. Trans. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e002025","DOI":"10.1161\/CIRCINTERVENTIONS.114.002025","article-title":"Routine Screening of Coronary Artery Disease With Computed Tomographic Coronary Angiography in Place of Invasive Coronary Angiography in Patients Undergoing Transcatheter Aortic Valve Replacement","volume":"8","author":"Chieffo","year":"2015","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijcard.2015.06.166","article-title":"Management of concomitant coronary artery disease in patients undergoing transcatheter aortic valve implantation: The United Kingdom TAVI Registry","volume":"199","author":"Snow","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jacc.2015.10.103","article-title":"Outcomes in Patients with Transcatheter Aortic Valve Replacement and Left Main Stenting","volume":"67","author":"Chakravarty","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/ccd.27440","article-title":"Coronary artery disease, revascularization, and clinical outcomes in transcatheter aortic valve replacement: Real-world results from the East Denmark Heart Registry","volume":"92","author":"Sawaya","year":"2018","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.jcin.2021.06.041","article-title":"ACTIVATION (PercutAneous Coronary inTervention prIor to transcatheter aortic VAlve implantaTION): A Randomized Clinical Trial","volume":"14","author":"Patterson","year":"2021","journal-title":"JACC Cardiovasc. Interv."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/6\/2285\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:55:47Z","timestamp":1760122547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/6\/2285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jcm12062285"],"URL":"https:\/\/doi.org\/10.3390\/jcm12062285","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}