{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:40:42Z","timestamp":1781671242149,"version":"3.54.5"},"reference-count":70,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Rates of late allograft loss have improved slowly in the last decades. Well described traditional risk factors that influence allograft survival include cardiovascular events, rejection, infections and post-transplant neoplasia. Here, we critically evaluate the influence of several non-immunological, non-traditional risk factors and describe their impact on allograft survival and cardiovascular health of kidney transplant recipients. We assessed the following risk factors: arterial stiffness, persistent arteriovenous access, mineral bone disease, immunosuppressive drugs residual levels variability, hypomagnesemia, glomerular pathological alterations not included in Banff criteria, persistent inflammation and metabolic acidosis.<\/jats:p>","DOI":"10.3390\/jcm12062364","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T03:09:37Z","timestamp":1679281777000},"page":"2364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Non-Traditional Non-Immunological Risk Factors for Kidney Allograft Loss\u2014Opinion"],"prefix":"10.3390","volume":"12","author":[{"given":"Titus","family":"Andrian","sequence":"first","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"},{"name":"Department of Internal Medicine, \u2018Grigore T. Popa\u2019 University of Medicine, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"Siriteanu","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"},{"name":"Department of Internal Medicine, \u2018Grigore T. Popa\u2019 University of Medicine, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Simona","family":"Covic","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"},{"name":"Department of Internal Medicine, \u2018Grigore T. Popa\u2019 University of Medicine, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Alexandra","family":"Ipate","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Miron","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"},{"name":"Department of Internal Medicine, \u2018Grigore T. Popa\u2019 University of Medicine, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corneliu","family":"Morosanu","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina-Draga","family":"Caruntu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u2018Grigore T. Popa\u2019 University of Medicine, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-2486","authenticated-orcid":false,"given":"Adrian","family":"Covic","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center, C. I. Parhon University Hospital, 700503 Iasi, Romania"},{"name":"Department of Internal Medicine, \u2018Grigore T. Popa\u2019 University of Medicine, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e068769","DOI":"10.1136\/bmj-2021-068769","article-title":"Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: Systematic review and meta-analysis","volume":"376","author":"Chaudhry","year":"2022","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/S0140-6736(17)31283-7","article-title":"Strategies for long-term preservation of kidney graft function","volume":"389","author":"Wekerle","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1056\/NEJMra2014530","article-title":"Long-Term Survival after Kidney Transplantation","volume":"385","author":"Hariharan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(11)60699-5","article-title":"Diagnosis and prevention of chronic kidney allograft loss","volume":"378","author":"Nankivell","year":"2011","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2215\/CJN.14620920","article-title":"Managing Patients with Failing Kidney Allograft: Many Questions Remain","volume":"17","author":"Davis","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ki.2014.6","article-title":"Similar patient survival following kidney allograft failure compared with non-transplanted patients","volume":"86","author":"Mourad","year":"2014","journal-title":"Kidney Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/TP.0000000000000183","article-title":"The histology of kidney transplant failure: A long-term follow-up study","volume":"98","author":"Naesens","year":"2014","journal-title":"Transplantation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1097\/TP.0000000000003012","article-title":"The Causes of Kidney Allograft Failure: More Than Alloimmunity. A Viewpoint Article","volume":"104","author":"Bernards","year":"2020","journal-title":"Transplantation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1681\/ASN.2020081215","article-title":"Exploring the Complexity of Death-Censored Kidney Allograft Failure","volume":"32","author":"Mayrdorfer","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1681\/ASN.2020040464","article-title":"Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and Outcomes","volume":"32","author":"Reese","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e026166","DOI":"10.1136\/bmjopen-2018-026166","article-title":"PreImplantation Trial of Histopathology In renal Allografts (PITHIA): A stepped-wedge cluster randomised controlled trial protocol","volume":"9","author":"Ayorinde","year":"2019","journal-title":"BMJ Open"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.kint.2020.07.025","article-title":"Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation","volume":"99","author":"Raynaud","year":"2021","journal-title":"Kidney Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e2141617","DOI":"10.1001\/jamanetworkopen.2021.41617","article-title":"Forecasting of Patient-Specific Kidney Transplant Function With a Sequence-to-Sequence Deep Learning Model","volume":"4","author":"Zhang","year":"2021","journal-title":"JAMA Netw. 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Dial. Transplant."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/TP.0000000000003990","article-title":"New Approaches to Cardiovascular Disease and Its Management in Kidney Transplant Recipients","volume":"106","author":"Aziz","year":"2022","journal-title":"Transplantation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.2215\/CJN.03000315","article-title":"Arterial Stiffness and Decline in Kidney Function","volume":"10","author":"Sedaghat","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/01.HYP.0000201234.35551.2e","article-title":"Aortic stiffness, living donors, and renal transplantation","volume":"47","author":"Bahous","year":"2006","journal-title":"Hypertension"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1600-6143.2006.01341.x","article-title":"Impaired renal allograft function is associated with increased arterial stiffness in renal transplant recipients","volume":"6","author":"Kneifel","year":"2006","journal-title":"Am. J. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/HYPERTENSIONAHA.111.176594","article-title":"Aortic stiffness and central wave reflections predict outcome in renal transplant recipients","volume":"58","author":"Verbeke","year":"2011","journal-title":"Hypertension"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/TP.0000000000000660","article-title":"Aortic Stiffness in a Mortality Risk Calculator for Kidney Transplant Recipients","volume":"99","author":"Dahle","year":"2015","journal-title":"Transplantation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e006078","DOI":"10.1161\/JAHA.117.006078","article-title":"Reversal of Arterial Stiffness and Maladaptative Arterial Remodeling After Kidney Transplantation","volume":"6","author":"Karras","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/HYPERTENSIONAHA.110.167486","article-title":"Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease","volume":"57","author":"Dhaun","year":"2011","journal-title":"Hypertension"},{"key":"ref_25","first-page":"58","article-title":"Arterial stiffness in kidney transplantation: A single center case-control study comparing belatacept versus calcineurin inhibitor immunosuppressive based regimen","volume":"35","author":"Melilli","year":"2015","journal-title":"Nefrologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1681\/ASN.2019020117","article-title":"Arterial Stiffness in the Heart Disease of CKD","volume":"30","author":"Zanoli","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.avsg.2019.06.040","article-title":"To Ligate or Not to Ligate: A Meta-analysis of Cardiac Effects and Allograft Function following Arteriovenous Fistula Closure in Renal Transplant Recipients","volume":"63","author":"Zheng","year":"2020","journal-title":"Ann. Vasc. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Vajdi\u010d Trampu\u017e, B., Arnol, M., Guben\u0161ek, J., Ponikvar, R., and Buturovi\u0107 Ponikvar, J. (2021). A national cohort study on hemodialysis arteriovenous fistulas after kidney transplantation-long-term patency, use and complications. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02550-4"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1111\/jgs.15962","article-title":"Fractures and Subsequent Graft Loss and Mortality among Older Kidney Transplant Recipients","volume":"67","author":"Salter","year":"2019","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.transproceed.2011.12.050","article-title":"Clinical manifestations of hypercalcemia and hypophosphatemia after kidney transplantation","volume":"44","author":"Kim","year":"2012","journal-title":"Transplant. Proc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s11255-016-1391-z","article-title":"The effect of hypercalcemia on allograft calcification after kidney transplantation","volume":"48","author":"Demirci","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1111\/ajt.12911","article-title":"A randomized study evaluating cinacalcet to treat hypercalcemia in renal transplant recipients with persistent hyperparathyroidism","volume":"14","author":"Evenepoel","year":"2014","journal-title":"Am. J. Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1681\/ASN.2015060622","article-title":"A Randomized Study Comparing Parathyroidectomy with Cinacalcet for Treating Hypercalcemia in Kidney Allograft Recipients with Hyperparathyroidism","volume":"27","author":"Cruzado","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2215\/CJN.03410321","article-title":"Bone and Mineral Disease in Kidney Transplant Recipients","volume":"17","author":"Khairallah","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.2215\/CJN.01910212","article-title":"Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes","volume":"7","author":"Molnar","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/jc.2014-3012","article-title":"Associations of 25(OH) and 1,25(OH)2 vitamin D with long-term outcomes in stable renal transplant recipients","volume":"100","author":"Keyzer","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000446863","article-title":"Vitamin D in Kidney Transplant Recipients: Mechanisms and Therapy","volume":"43","author":"Cianciolo","year":"2016","journal-title":"Am. J. Nephrol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/tri.12973","article-title":"Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study","volume":"30","author":"Gatti","year":"2017","journal-title":"Transpl. Int."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group (2017). KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int. Suppl., 7, 1\u201359.","DOI":"10.1016\/j.kisu.2017.04.001"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2215\/CJN.14840920","article-title":"Beyond the Biopsy: Monitoring Immune Status in Kidney Recipients","volume":"16","author":"Bloom","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/ki.2013.465","article-title":"Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure","volume":"85","author":"Wang","year":"2014","journal-title":"Kidney Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/ndt\/gfq096","article-title":"High within-patient variability in the clearance of tacrolimus is a risk factor for poor long-term outcome after kidney transplantation","volume":"25","author":"Borra","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1681\/ASN.V1161122","article-title":"Low intraindividual variability of cyclosporin A exposure reduces chronic rejection incidence and health care costs","volume":"11","author":"Kahan","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/TP.0000000000001040","article-title":"Within-Patient Variability in Tacrolimus Blood Levels Predicts Kidney Graft Loss and Donor-Specific Antibody Development","volume":"100","author":"Rodrigo","year":"2016","journal-title":"Transplantation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/TP.0000000000002913","article-title":"Tacrolimus Intrapatient Variability, Time in Therapeutic Range, and Risk of De Novo Donor-Specific Antibodies","volume":"104","author":"Davis","year":"2020","journal-title":"Transplantation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1016\/j.transproceed.2021.09.012","article-title":"Longitudinal Assessment of Electrolyte Disorders in a Cohort of Chronic Stable Kidney Transplant Recipients","volume":"53","author":"Duni","year":"2021","journal-title":"Transplant. Proc."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Garnier, A.S., Duveau, A., Planchais, M., Subra, J.F., Sayegh, J., and Augusto, J.F. (2018). Serum Magnesium after Kidney Transplantation: A Systematic Review. Nutrients, 10.","DOI":"10.3390\/nu10060729"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3109\/07435800.2015.1094088","article-title":"Hypomagnesemia linked to new-onset diabetes mellitus after kidney transplantation: A systematic review and meta-analysis","volume":"41","author":"Cheungpasitporn","year":"2016","journal-title":"Endocr. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1681\/ASN.2015040391","article-title":"Hypomagnesemia and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation","volume":"27","author":"Huang","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Odler, B., Deak, A.T., Pregartner, G., Riedl, R., Bozic, J., Trummer, C., Prenner, A., S\u00f6llinger, L., Krall, M., and H\u00f6flechner, L. (2021). Hypomagnesemia Is a Risk Factor for Infections after Kidney Transplantation: A Retrospective Cohort Analysis. Nutrients, 13.","DOI":"10.3390\/nu13041296"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/ndt\/gfh831","article-title":"Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicity","volume":"20","author":"Holzmacher","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/tri.13932","article-title":"Post-kidney transplant serum magnesium exhibits a U-shaped association with subsequent mortality: An observational cohort study","volume":"34","author":"Panthofer","year":"2021","journal-title":"Transpl. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1159\/000510797","article-title":"Posttransplantation Hypomagnesemia as a Predictor of Better Graft Function after Transplantation","volume":"45","author":"Hod","year":"2020","journal-title":"Kidney Blood Press. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000522233","article-title":"Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation","volume":"47","author":"Isakov","year":"2022","journal-title":"Kidney Blood Press. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2215\/CJN.09470819","article-title":"Electrolyte Disorders in Kidney Transplantation","volume":"15","author":"Miles","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.kint.2021.11.028","article-title":"Thirty years of the International Banff Classification for Allograft Pathology: The past, present, and future of kidney transplant diagnostics","volume":"101","author":"Loupy","year":"2022","journal-title":"Kidney Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1681\/ASN.2022040418","article-title":"Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after Kidney Transplantation: Incidence and Correlation with Late Graft Failure","volume":"34","author":"Denic","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.kint.2022.07.030","article-title":"Long-term immunological outcomes of early subclinical inflammation on surveillance kidney allograft biopsies","volume":"102","author":"Mehta","year":"2022","journal-title":"Kidney Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.kint.2021.04.016","article-title":"The inflammatory state is a risk factor for cardiovascular disease and graft fibrosis in kidney transplantation","volume":"100","author":"Ponticelli","year":"2021","journal-title":"Kidney Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1097\/TP.0000000000001548","article-title":"Inflammatory Markers and Outcomes in Kidney Transplant Recipients","volume":"101","author":"Molnar","year":"2017","journal-title":"Transplantation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.2174\/138161212799504731","article-title":"Inflammation-induced thrombosis: Mechanisms, disease associations and management","volume":"18","author":"Aksu","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1111\/ajt.15862","article-title":"Inflammation in areas of fibrosis: The DeKAF prospective cohort","volume":"20","author":"Matas","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/ndt\/gfv098","article-title":"Metabolic acidosis in renal transplantation: Neglected but of potential clinical relevance","volume":"31","author":"Messa","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1681\/ASN.2016070793","article-title":"Metabolic Acidosis and Long-Term clinical Outcomes in Kidney Transplant Recipients","volume":"28","author":"Park","year":"2017","journal-title":"J. Am. Soc. 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