{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:50:51Z","timestamp":1767084651089,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Meril Life Sciences Pvt. Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Bicuspid aortic valve (BAV) affects approximately 1.5% of the general population and is seen in nearly 50% of candidates for aortic valve replacement (AVR). Despite increasingly utilised transcatheter aortic valve implantation (TAVI) in aortic stenosis (AS) patients, its use among patients with severe bicuspid AS is limited as BAV is a heterogeneous disease associated with multiple and complex anatomical challenges. Aim: To investigate the one-year outcomes of TAVI using the balloon-expandable Myval transcatheter heart valve (THV) (Meril Life Sciences Pvt. Ltd., Vapi, India) in patients with severe bicuspid AS. Methods and results: We collected data from consecutive patients with bicuspid AS who underwent TAVI with the Myval THV and had at least one-year follow-up. Baseline characteristics, procedural, and 30-day echocardiographic and clinical outcomes were collected. Sixty-two patients were included in the study. The median age was 72 [66.3, 77.0] years, 45 (72.6%) were males, and the mean STS PROM score was 3.2 \u00b1 2.2%. All TAVI procedures were performed via the transfemoral route. The median follow-up duration was 13.5 [12.2, 18.3] months; all-cause mortality was reported in 7 (11.3%) patients and cardiovascular hospitalisation in 6 (10.6%) patients. All-stroke was reported in 2 (3.2%), permanent pacemaker implantation 5 (8.3%), and myocardial infarction 1 (1.6%) patients. The echocardiographic assessment revealed a mean pressure gradient of 10 [8, 16.5] mmHg, effective orifice area 1.7 [1.4, 1.9] cm2, moderate AR in 1 (2%), mild AR in 14 (27%), and none\/trace AR in 37 (71%). In total, 1 patient was diagnosed with valve thrombosis (2.1%), Stage II (moderate) haemodynamic deterioration was seen in 3 (6.4%), and stage III (severe) haemodynamic deterioration in 1 (2.1%) patient. Conclusions: TAVI with the Myval THV in selected BAV anatomy is associated with favourable one-year hemodynamic and clinical outcomes.<\/jats:p>","DOI":"10.3390\/jcm12062398","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:56:37Z","timestamp":1679298997000},"page":"2398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["One-Year Outcomes after Myval Implantation in Patients with Bicuspid Aortic Valve Stenosis\u2014A Multicentre Real-World Experience"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-1056","authenticated-orcid":false,"given":"Ahmed","family":"Elkoumy","sequence":"first","affiliation":[{"name":"Health Service Executive and CORRIB Core Lab, Discipline of Cardiology, Saolta Group, Galway University Hospital, University of Galway, H91 V4AY Galway, Ireland"},{"name":"Islamic Center of Cardiology, Al-Azhar University, Cairo 11651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-815X","authenticated-orcid":false,"given":"John","family":"Jose","sequence":"additional","affiliation":[{"name":"Christian Medical College & Hospital, Vellore 632004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, 8200 Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sengottuvelu","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Apollo Main Hospital, Greams Road, Chennai 600006, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-0019","authenticated-orcid":false,"given":"Mahmoud","family":"Abdelshafy","sequence":"additional","affiliation":[{"name":"Health Service Executive and CORRIB Core Lab, Discipline of Cardiology, Saolta Group, Galway University Hospital, University of Galway, H91 V4AY Galway, Ireland"},{"name":"Department of Cardiology, Al-Azhar University, Cairo 11311, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Seth","sequence":"additional","affiliation":[{"name":"Fortis Escorts Heart Institute, New Delhi 110025, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Elzomor","sequence":"additional","affiliation":[{"name":"Health Service Executive and CORRIB Core Lab, Discipline of Cardiology, Saolta Group, Galway University Hospital, University of Galway, H91 V4AY Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreenivas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Apollo Hospitals, Apollo Health City, Jubilee Hills, Hyderabad 500050, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-1669","authenticated-orcid":false,"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"Clinical and Interventional Cardiology Unit, Istituto Clinico Sant\u2019Ambrogio, 20149 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Arsang-Jang","sequence":"additional","affiliation":[{"name":"Health Service Executive and CORRIB Core Lab, Discipline of Cardiology, Saolta Group, Galway University Hospital, University of Galway, H91 V4AY Galway, Ireland"},{"name":"C\u00daRAM\u2014SFI Research Centre for Medical Devices, H91 TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh Kumar","family":"Dora","sequence":"additional","affiliation":[{"name":"Asian Heart Institute, Mumbai 400051, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King George\u2019s Medical University, Lucknow 226003, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur","family":"Parikh","sequence":"additional","affiliation":[{"name":"Care Institute of Medical Sciences, Ahmedabad 380060, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Unic","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, University Hospital Dubrava, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7707-2254","authenticated-orcid":false,"given":"Andreas","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Serruys","sequence":"additional","affiliation":[{"name":"Health Service Executive and CORRIB Core Lab, Discipline of Cardiology, Saolta Group, Galway University Hospital, University of Galway, H91 V4AY Galway, Ireland"},{"name":"Clinical and Interventional Cardiology Unit, Istituto Clinico Sant\u2019Ambrogio, 20149 Milan, Italy"},{"name":"National Heart and Lung Institute (NHLI), Imperial College London, London SW7 2AZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[{"name":"Health Service Executive and CORRIB Core Lab, Discipline of Cardiology, Saolta Group, Galway University Hospital, University of Galway, H91 V4AY Galway, Ireland"},{"name":"C\u00daRAM\u2014SFI Research Centre for Medical Devices, H91 TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA Guideline for the Management of Patients with Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J. 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