{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:25:37Z","timestamp":1782735937169,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"state assignment of Ministry of Health","award":["121032500126-3"],"award-info":[{"award-number":["121032500126-3"]}]},{"name":"state assignment of Ministry of Health","award":["030907-2-074"],"award-info":[{"award-number":["030907-2-074"]}]},{"name":"RUDN University Scientific","award":["121032500126-3"],"award-info":[{"award-number":["121032500126-3"]}]},{"name":"RUDN University Scientific","award":["030907-2-074"],"award-info":[{"award-number":["030907-2-074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Diagnostic and treatment delays have caused significant impacts on the physical and emotional well-being of adolescents with endometriosis, though such research is limited. This study aimed to assess the effects of one-year dienogest therapy on the clinical picture, pain patterns, psycho-emotional status, and quality-of-life indicators in adolescents with endometriosis after surgical treatment. Methods: The study enrolled 32 girls aged 13\u201317 with peritoneal endometriosis to analyze one-year dynamics of the Visual Analog Scale (VAS), McGill Pain Questionnaire, Beck Depression Scale (BDI), Hospital Anxiety and Depression Scale (HADS), Spielberger State-Trait Anxiety Inventory (STAI) and SF-36 quality-of-life survey scores along with clinical and laboratory indicators before surgery and after one-year dienogest therapy. Results. The therapy provided a significant alleviation of endometriosis-associated clinical symptoms, including dysmenorrhea, pelvic pain, gastrointestinal\/dysuria symptoms, decreased everyday activity (&lt;0.001), a decrease in anxiety\/depression scores (BDI, HADS, STAI), and quality-of-life improvement (&lt;0.001). These effects were accompanied by beneficial dynamics in hormone and inflammatory markers (prolactin, cortisol, testosterone, estradiol, CA-125, neutrophil\/lymphocyte ratio; &lt;0.005) within reference ranges. A low body mass index and high C-reactive protein levels were associated with higher VAS scores; a high estradiol level was a factor for anxiety\/depression aggravation (&lt;0.05). Conclusions: Dienogest, after surgical treatment, significantly improved quality of life and reduced pain symptoms while showing good tolerability and compliance, and reasoning with timely hormonal therapy in adolescents with endometriosis.<\/jats:p>","DOI":"10.3390\/jcm12062400","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T02:36:22Z","timestamp":1679366182000},"page":"2400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pelvic Pain, Mental Health and Quality of Life in Adolescents with Endometriosis after Surgery and Dienogest Treatment"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-307X","authenticated-orcid":false,"given":"Elena P.","family":"Khashchenko","sequence":"first","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Uvarova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department for Obstetrics, Gynecology, Perinatology and Reproduction, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir D.","family":"Chuprynin","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita Yu.","family":"Pustynnikova","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Moscow State University Named after M.V. Lomonosov, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-5764","authenticated-orcid":false,"given":"Timur Kh.","family":"Fatkhudinov","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department of Histology, Cytology and Embryology, Peoples\u2019 Friendship University of Russia (RUDN), Miklukho-Maklaya Str. 6, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-4439","authenticated-orcid":false,"given":"Andrey V.","family":"Elchaninov","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department of Histology, Cytology and Embryology, Peoples\u2019 Friendship University of Russia (RUDN), Miklukho-Maklaya Str. 6, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna R.","family":"Gardanova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-0276","authenticated-orcid":false,"given":"Tatyana Yu.","family":"Ivanets","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-6201","authenticated-orcid":false,"given":"Mikhail Yu.","family":"Vysokikh","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"A.N. Belozersky Research Institute of Physico-Chemical Biology MSU, Leninskye Gory, House 1, Building 40, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennady T.","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department for Obstetrics, Gynecology, Perinatology and Reproduction, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S1083-3188(03)00066-4","article-title":"Adolescent Endometriosis: Diagnosis and Treatment Approaches","volume":"16","author":"Laufer","year":"2003","journal-title":"J. Pediatr. Adolesc. 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