{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:27:28Z","timestamp":1790659648478,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Obesity-hypoventilation syndrome (OHS) is associated with many comorbidities. The aim of this study was to evaluate the association between previous continuous positive airway pressure (CPAP) and the prevalence of comorbidities in OHS associated with obstructive sleep apnea (OSA). We performed a retrospective, single-center study at the University Hospital of Martinique, the referral hospital for the island of Martinique. A total of 97 patients with OHS associated with severe OSA on non-invasive ventilation (NIV) were included; 54 patients (56%) had previous treatment of OSA with a positive airway pressure (PAP) device before shifting to NIV (PAP group) and 43 (44%) had no previous treatment of OSA with a PAP device before initiating NIV PAP (no PAP group). Sociodemographic characteristics were similar between groups; there were 40 women (74%) in the PAP group versus 34 (79%) in the no PAP group, mean age at OHS diagnosis was 66 \u00b1 15 versus 67 \u00b1 16 years, respectively, and the mean age at inclusion 72 \u00b1 14 versus 71 \u00b1 15 years, respectively. The average number of comorbidities was 4 \u00b1 1 in the PAP group versus 4 \u00b1 2 in the no PAP group; the mean Charlson index was 5 \u00b1 2 in both groups. The mean BMI was 42 \u00b1 8 kg\/m2 in both groups. The mean follow-up duration was 5.8 \u00b1 4.4 years in the PAP group versus 4.7 \u00b1 3.5 years in the no PAP group. Chronic heart failure was less common in patients who had a previous PAP 30% versus 53% (p = 0.02). It is also noted that these patients were diagnosed less often in the context of acute respiratory failure in patients with previous PAP: 56% versus 93% (p &lt; 0.0001). In contrast, asthma patients were more frequent in patients with previous treatment of OSA with a PAP device at the time of OHS diagnosis but not significantly: 37% versus 19% (p = 0.07). Early treatment of severe OSA with a PAP device prior to diagnosis of OHS seems to be associated with a reduced prevalence of cardiac diseases, notably chronic heart failure, in patients diagnosed with OHS associated with severe OSA.<\/jats:p>","DOI":"10.3390\/jcm12072448","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T02:35:26Z","timestamp":1679538926000},"page":"2448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between Previous CPAP and Comorbidities at Diagnosis of Obesity-Hypoventilation Syndrome Associated with Obstructive Sleep Apnea: A Comparative Retrospective Observational Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Moustapha","family":"Agossou","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Awanou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1057-9699","authenticated-orcid":false,"given":"Jocelyn","family":"Inamo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Dufeal","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3289-366X","authenticated-orcid":false,"given":"Jean-Michel","family":"Arnal","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente, H\u00f4pital Sainte Musse, 83100 Toulon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-8832","authenticated-orcid":false,"given":"Moustapha","family":"Dram\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation, University Hospital of Martinique, 97200 Fort-de-France, France"},{"name":"EpiCliV Research Unit, Faculty of Medicine, University of the French West Indies, 97261 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","unstructured":"Wilson, M.W., Labaki, W.W., and Choi, P.J. 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