{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:11:55Z","timestamp":1768313515456,"version":"3.49.0"},"reference-count":19,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The six-minute walk test is a practical tool for assessing functional capacity in patients with a variety of etiologies including pulmonary disease and heart failure. Six-minute walk distance (6MWD) is associated with mortality and morbidity in patients with a variety of comorbidities. We aimed to assess the prognostic impact of baseline 6MWD in patients with severe aortic stenosis undergoing trans-catheter aortic valve replacement (TAVR). Methods: Patients with severe aortic stenosis who underwent a six-minute walk test after index admission and underwent TAVR between 2015 and 2022 were included in this retrospective study. Patients were followed up for two years or until November 2022 following TAVR. The impact of baseline 6MWD on the primary composite outcome, defined as all-cause death and all-cause readmission during the 2-year observation period following index discharge, was assessed. Results: A total of 299 patients (median age 86 years old, 85 men) were included. They received a 6-min walk test prior to TAVR, underwent successful TAVR procedures, and were discharged alive. The median baseline 6MWD was 204 (143, 282) meters. Shorter baseline 6MWD was associated with higher cumulative incidence of the primary outcome with an adjusted hazard ratio of 0.76 (95% confidence interval 0.58\u20131.01, p = 0.055) with a cutoff 6MWD of 178 m during the 2-year observation period after index discharge. Conclusions: Overall, functional capacity was impaired in the elderly patients with severe aortic stenosis prior to TAVR. Patients with severe aortic stenosis having shorter baseline 6MWD tended to have higher rates of morbidity and mortality after successful TAVR. The clinical implication of aggressive cardiac rehabilitation to improve patients\u2019 functional capacity and 6MWD-guided optimal patient selection remain the future concerns.<\/jats:p>","DOI":"10.3390\/jcm12072504","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:18:27Z","timestamp":1679883507000},"page":"2504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Impact of Baseline Six-Minute Walk Distance following Trans-Catheter Aortic Valve Replacement"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-7637","authenticated-orcid":false,"given":"Teruhiko","family":"Imamura","sequence":"first","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Narang","sequence":"additional","affiliation":[{"name":"Advocate Christ Medical Center, Oak Lawn, IL 60453, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Ushijima","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Sobajima","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Fukuda","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-2511","authenticated-orcid":false,"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kinugawa","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus surgical aortic-valve replacement in high-risk patients","volume":"364","author":"Smith","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_3","unstructured":"Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC), European Association for Cardio-Thoracic, Surgery (EACTS), Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M.J., Baron-Esquivias, G., Baumgartner, H., Borger, M.A., and Carrel, T.P. (2012). Guidelines on the management of valvular heart disease (version 2012). Eur. Heart J., 33, 2451\u20132496."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jacc.2013.04.057","article-title":"Prognostic value of chronic kidney disease after transcatheter aortic valve implantation","volume":"62","author":"Yamamoto","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1161\/CIRCULATIONAHA.116.025630","article-title":"Impact of the Clinical Frailty Scale on Outcomes After Transcatheter Aortic Valve Replacement","volume":"135","author":"Shimura","year":"2017","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jcin.2012.02.012","article-title":"Evaluation of multidimensional geriatric assessment as a predictor of mortality and cardiovascular events after transcatheter aortic valve implantation","volume":"5","author":"Stortecky","year":"2012","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ejheart.2003.11.024","article-title":"The 6 minute walking test in chronic heart failure: Indications, interpretation and limitations from a review of the literature","volume":"6","author":"Faggiano","year":"2004","journal-title":"Eur. J. Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1164\/ajrccm.167.9.950","article-title":"ATS statement on six-minute walk test","volume":"167","author":"Brooks","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejheart.2005.07.008","article-title":"Predicting peak oxygen uptake from 6-min walk test performance in male patients with left ventricular systolic dysfunction","volume":"8","author":"Ingle","year":"2006","journal-title":"Eur. J. Heart Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/ggi.13830","article-title":"Chapter 1 Frailty: Definition, diagnosis, epidemiology","volume":"20","author":"Satake","year":"2020","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: Evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.carrev.2021.02.004","article-title":"Frailty Predicts Adverse Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Replacement (TAVR): From the National Inpatient Sample","volume":"34","author":"Abugroun","year":"2022","journal-title":"Cardiovasc. Revascularization Med. Incl. Mol. Interv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jacc.2017.06.024","article-title":"Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study","volume":"70","author":"Afilalo","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","first-page":"609","article-title":"Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: Risk assessment by Katz Index of activities of daily living","volume":"10","author":"Puls","year":"2014","journal-title":"Eurointerv. J. EuroPCR Collab. Work. Group Interv. Cardiol. Eur. Soc. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jcsm.12689","article-title":"Frailty in patients undergoing transcatheter aortic valve replacement: Prognostic value of the Geriatric Nutritional Risk Index","volume":"12","author":"Seoudy","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijcard.2021.11.087","article-title":"Muscle fat index is associated with frailty and length of hospital stay following transcatheter aortic valve replacement in high-risk patients","volume":"348","author":"Heidari","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.amjcard.2013.04.046","article-title":"Relation between six-minute walk test performance and outcomes after transcatheter aortic valve implantation (from the PARTNER trial)","volume":"112","author":"Green","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e009175","DOI":"10.1161\/CIRCOUTCOMES.122.009175","article-title":"Variation in Cardiac Rehabilitation Participation During Aortic Valve Replacement Episodes of Care","volume":"15","author":"Guduguntla","year":"2022","journal-title":"Circulation. Cardiovasc. Qual. Outcomes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5603\/CJ.a2016.0086","article-title":"Assessment of cardiovascular function following transcatheter aortic valve implantation based on six-minute walk test","volume":"24","author":"Chodor","year":"2017","journal-title":"Cardiol. J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/7\/2504\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:03:24Z","timestamp":1760123004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/7\/2504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,26]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["jcm12072504"],"URL":"https:\/\/doi.org\/10.3390\/jcm12072504","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,26]]}}}