{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:00:54Z","timestamp":1760148054798,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Current guidelines recommend delaying noncardiac surgery for 6 months after drug eluting stent implantation. However, this recommendation is largely based on limited evidence and various event definitions. Whether early surgery within 6 months of coronary stent implantation increases myocardial injury in patients with normal preoperative high-sensitivity cardiac troponin I (hs-cTnI) has not yet been investigated. This retrospective study assessed patients who received coronary stent implantation and underwent noncardiac surgery (vascular, abdominal, or thoracic) between 2010 and 2017 with normal preoperative hs-cTnI (n = 186). Patients were divided into early (within 6 months of PCI) and late (after 6 months of PCI) groups. The primary endpoint was the incidence of myocardial injury as diagnosed by hs-cTnI within 3 days post-operation. The secondary outcomes were myocardial infarction, stent thrombosis, emergent coronary revascularization, major bleeding (bleeding requiring transfusion or intracranial bleeding), stroke, renal failure, heart failure, or death within 30 days post-operation. Inverse probability treatment weighting (IPTW) was carried out to adjust for the intergroup baseline differences. Myocardial injury occurred in 28.6% (8\/28) and 27.8% (44\/158) of the early and late groups, respectively, with no difference between groups (odds ratio [OR] 1.067, 95% confidence interval [CI] 0.404, 2.482; p = 0.886). Secondary outcomes did not differ between the groups. IPTW analysis also showed no differences in myocardial injury and secondary outcomes between the groups. In conclusion, early surgery within 6 months after coronary stent implantation did not increase the incidence of myocardial injury in patients with normal preoperative hs-cTnI.<\/jats:p>","DOI":"10.3390\/jcm12072524","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T01:41:34Z","timestamp":1679967694000},"page":"2524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Early and Late Surgeries after Coronary Stent Implantation in Patients with Normal Preoperative Troponin Level: A Retrospective Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Sang Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-5332","authenticated-orcid":false,"given":"Eun Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1576-5308","authenticated-orcid":false,"given":"Hyun Joo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangmin M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie Ae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikyung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7263-0867","authenticated-orcid":false,"given":"Jeayoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heejoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungmo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinseo","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedical Statistics Center, Data Science Research Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5768-5990","authenticated-orcid":false,"given":"Joonghyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Biomedical Statistics Center, Data Science Research Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jcin.2010.03.021","article-title":"Frequency of major noncardiac surgery and subsequent adverse events in the year after drug-eluting stent placement results from the EVENT (Evaluation of Drug-Eluting Stents and Ischemic Events) Registry","volume":"3","author":"Berger","year":"2010","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/jama.2013.278787","article-title":"Risk of major adverse cardiac events following noncardiac surgery in patients with coronary stents","volume":"310","author":"Hawn","year":"2013","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/ALN.0b013e3181928913","article-title":"Practice alert for the perioperative management of patients with coronary artery stents: A report by the American Society of Anesthesiologists Committee on Standards and Practice Parameters","volume":"110","author":"Caplan","year":"2009","journal-title":"Anesthesiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/ALN.0000000000000451","article-title":"Perioperative management of the patient with a coronary artery stent","volume":"121","author":"Vetter","year":"2014","journal-title":"Anesthesiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jacc.2016.03.513","article-title":"2016 ACC\/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"68","author":"Levine","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/eurheartj\/ehx419","article-title":"2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"39","author":"Valgimigli","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cjca.2017.12.012","article-title":"2018 Canadian Cardiovascular Society\/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy","volume":"34","author":"Mehta","year":"2018","journal-title":"Can. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1136\/hrt.2011.224519","article-title":"Non-cardiac surgery in patients with coronary stents: The RECO study","volume":"97","author":"Albaladejo","year":"2011","journal-title":"Heart"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.amjsurg.2012.04.008","article-title":"Adverse cardiac events in patients with coronary stents undergoing noncardiac surgery: A systematic review","volume":"204","author":"Hollis","year":"2012","journal-title":"Am. J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/CIRCINTERVENTIONS.109.934703","article-title":"Previous coronary stent implantation and cardiac events in patients undergoing noncardiac surgery","volume":"3","author":"Cruden","year":"2010","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/ALN.0b013e318186de1c","article-title":"Cardiac risk of noncardiac surgery after percutaneous coronary intervention with drug-eluting stents","volume":"109","author":"Rabbitts","year":"2008","journal-title":"Anesthesiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1016\/j.jacc.2014.09.072","article-title":"The incremental risk of noncardiac surgery on adverse cardiac events following coronary stenting","volume":"64","author":"Holcomb","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/CIRCULATIONAHA.112.102715","article-title":"Risk of elective major noncardiac surgery after coronary stent insertion: A population-based study","volume":"126","author":"Wijeysundera","year":"2012","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1016\/j.jacc.2016.09.967","article-title":"Risk Associated With Surgery Within 12 Months After Coronary Drug-Eluting Stent Implantation","volume":"68","author":"Egholm","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.amjcard.2021.08.040","article-title":"Risk of Myocardial Infarction and Death After Noncardiac Surgery Performed Within the First Year After Coronary Drug-Eluting Stent Implantation for Acute Coronary Syndrome or Stable Angina Pectoris","volume":"160","author":"Thim","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0735-1097(00)00521-0","article-title":"Catastrophic outcomes of noncardiac surgery soon after coronary stenting","volume":"35","author":"Kaluza","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0735-1097(03)00622-3","article-title":"Clinical outcome of patients undergoing non-cardiac surgery in the two months following coronary stenting","volume":"42","author":"Wilson","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacc.2006.10.004","article-title":"Noncardiac surgery after coronary stenting: Early surgery and interruption of antiplatelet therapy are associated with an increase in major adverse cardiac events","volume":"49","author":"Schouten","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.amjcard.2009.06.038","article-title":"Timing of noncardiac surgery after coronary artery stenting with bare metal or drug-eluting stents","volume":"104","author":"Flu","year":"2009","journal-title":"Am. J. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/bja\/ael083","article-title":"Coronary artery stenting and non-cardiac surgery--a prospective outcome study","volume":"96","author":"Vicenzi","year":"2006","journal-title":"Br. J. Anaesth."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/CIRCULATIONAHA.106.180944","article-title":"Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: A science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians","volume":"115","author":"Grines","year":"2007","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jcin.2009.03.014","article-title":"Characterization of post-operative risk associated with prior drug-eluting stent use","volume":"2","author":"Anwaruddin","year":"2009","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1161\/CIR.0b013e31826e1058","article-title":"Third universal definition of myocardial infarction","volume":"126","author":"Thygesen","year":"2012","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nguyen, T.L., Collins, G.S., Spence, J., Daur\u00e8s, J.P., Devereaux, P.J., Landais, P., and Le Manach, Y. (2017). Double-adjustment in propensity score matching analysis: Choosing a threshold for considering residual imbalance. BMC Med. Res. Methodol., 17.","DOI":"10.1186\/s12874-017-0338-0"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.113.002128","article-title":"Myocardial injury after noncardiac surgery and its association with short-term mortality","volume":"127","author":"Nathoe","year":"2013","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1161\/CIR.0000000000001024","article-title":"Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association","volume":"144","author":"Ruetzler","year":"2021","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/bja\/aen033","article-title":"Drug-eluting stent thrombosis in patients undergoing non-cardiac surgery: Is it always a problem?","volume":"100","author":"Godet","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1097\/ALN.0000000000002107","article-title":"Etiology of Acute Coronary Syndrome after Noncardiac Surgery","volume":"128","author":"Helwani","year":"2018","journal-title":"Anesthesiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/bja\/aev556","article-title":"Effectiveness of platelet inhibition on major adverse cardiac events in non-cardiac surgery after percutaneous coronary intervention: A prospective cohort study","volume":"116","author":"Wasowicz","year":"2016","journal-title":"Br. J. Anaesth."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/2047487318798925","article-title":"Causes and prevention of postoperative myocardial injury","volume":"26","author":"Grobben","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.biomaterials.2009.09.079","article-title":"Endothelial cell recovery, acute thrombogenicity, and monocyte adhesion and activation on fluorinated copolymer and phosphorylcholine polymer stent coatings","volume":"31","author":"Hsu","year":"2010","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.15420\/ecr.2018:8:2","article-title":"The Newest Generation of Drug-eluting Stents and Beyond","volume":"13","author":"Lee","year":"2018","journal-title":"Eur. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCULATIONAHA.113.001790","article-title":"Pathology of second-generation everolimus-eluting stents versus first-generation sirolimus- and paclitaxel-eluting stents in humans","volume":"129","author":"Otsuka","year":"2014","journal-title":"Circulation"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.jacc.2013.08.725","article-title":"Stent thrombosis with drug-eluting stents: Is the paradigm shifting?","volume":"62","author":"Palmerini","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4244\/EIJV8I5A92","article-title":"Stent thrombosis: Insights on outcomes, predictors and impact of dual antiplatelet therapy interruption from the SPIRIT II, SPIRIT III, SPIRIT IV and COMPARE trials","volume":"8","author":"Kedhi","year":"2012","journal-title":"EuroIntervention"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/jcmm.13936","article-title":"The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?","volume":"23","author":"Cornelissen","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.2337\/dc18-2356","article-title":"Effects of Metformin Therapy on Coronary Endothelial Dysfunction in Patients With Prediabetes With Stable Angina and Nonobstructive Coronary Artery Stenosis: The CODYCE Multicenter Prospective Study","volume":"42","author":"Sardu","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13098-017-0304-3","article-title":"Effects of incretin treatment on cardiovascular outcomes in diabetic STEMI-patients with culprit obstructive and multivessel non obstructive-coronary-stenosis","volume":"10","author":"Marfella","year":"2018","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/dom.13122","article-title":"Non-ST-elevation myocardial infarction outcomes in patients with type 2 diabetes with non-obstructive coronary artery stenosis: Effects of incretin treatment","volume":"20","author":"Marfella","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"106597","DOI":"10.1016\/j.phrs.2022.106597","article-title":"Outcomes in diabetic patients treated with SGLT2-Inhibitors with acute myocardial infarction undergoing PCI: The SGLT2-I AMI PROTECT Registry","volume":"187","author":"Paolisso","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12933-022-01506-8","article-title":"Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: A multicenter international registry","volume":"21","author":"Paolisso","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCINTERVENTIONS.111.963728","article-title":"Incidence and outcome of surgical procedures after coronary bare-metal and drug-eluting stent implantation: A report from the CREDO-Kyoto PCI\/CABG registry cohort-2","volume":"5","author":"Tokushige","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jcin.2017.10.051","article-title":"A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery: Surgery After Stenting 2","volume":"11","author":"Rossini","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4070\/kcj.2020.0537","article-title":"Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: A Pandora Box to Explain Prognostic Differences","volume":"51","author":"Kim","year":"2021","journal-title":"Korean Circ. J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/7\/2524\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:04:16Z","timestamp":1760123056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/7\/2524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["jcm12072524"],"URL":"https:\/\/doi.org\/10.3390\/jcm12072524","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,3,27]]}}}