{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T13:18:38Z","timestamp":1776604718159,"version":"3.51.2"},"reference-count":27,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of this opinion paper is to determine the entities that define the maximal urethral pressure (MUP) during rest and during bladder filling that is needed to guarantee continence in females. For the development of this opinion, the literature was searched for via the Pubmed database and historic sources. Animal studies indicate that the maximal urethral pressure is determined by the smooth muscle activity in the mid-urethra. Additionally, during increased smooth muscle tone development, the largest sympathetic responses are found in the middle part of the urethra. This could be confirmed in human studies that are unable to find striated EMG activity in this area. Moreover, the external urethral striated sphincter is situated at the distal urethra, which is not the area with the highest pressure. The external urethral sphincter only provides additional urethral pressure in situations of exertion and physical activity. From a physics point of view, the phasic pressure of the external striated sphincter at the distal urethra cannot be added to the tonic pressure generated by the smooth muscle in the mid-urethra. The assertion that mid-urethral pressure is the result of different pressure forces around the urethra, including that of the external striated sphincter, is not supported by basic research evidence combined with physical calculation and should therefore be considered a misconception in the field of functional urology.<\/jats:p>","DOI":"10.3390\/jcm12072575","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T01:05:26Z","timestamp":1680138326000},"page":"2575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Maximal Urethral Pressure at Rest and during Normal Bladder Filling Is Only Determined by the Activity of the Urethral Smooth Musculature in the Female"],"prefix":"10.3390","volume":"12","author":[{"given":"Pieter L.","family":"Venema","sequence":"first","affiliation":[{"name":"Department of Urology, Maastricht University Medical Center, P. Debeyelaan 25, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guus","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Urology, Maastricht University Medical Center, P. Debeyelaan 25, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gommert A.","family":"van Koeveringe","sequence":"additional","affiliation":[{"name":"Department of Urology, Maastricht University Medical Center, P. Debeyelaan 25, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P. F. A.","family":"Heesakkers","sequence":"additional","affiliation":[{"name":"Department of Urology, Maastricht University Medical Center, P. Debeyelaan 25, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","first-page":"343","article-title":"Factors maintaining the intra urethral pressure","volume":"17","author":"Rud","year":"1979","journal-title":"Investig. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0022-5347(17)62730-7","article-title":"Constant urethral flow in female dog. Normal vesical and urethral pressure and effect of muscle relaxant","volume":"99","author":"Cass","year":"1968","journal-title":"J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1464-410X.1972.tb10064.x","article-title":"Analysis of the urethral pressure profile by means of electromyography and administration of drugs","volume":"44","author":"Donker","year":"1972","journal-title":"Br. J. 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