{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:20:32Z","timestamp":1774898432540,"version":"3.50.1"},"reference-count":72,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DORIAN EU FP7 (DORIAN\u2013Developmental ORIgins of healthy and unhealthy AgeiNg: The role of maternal obesity","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"Academy of Finland","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"Finnish Cultural Foundation","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"South-Western Finland Cultural Foundation","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"Turku University Foundation","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"University of Turku","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"Turku University Hospital","award":["278603"],"award-info":[{"award-number":["278603"]}]},{"name":"\u00c5bo Academy","award":["278603"],"award-info":[{"award-number":["278603"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean\/normal-weight mothers (OLM) and 17 offspring of obese\/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.<\/jats:p>","DOI":"10.3390\/jcm12072684","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T01:35:59Z","timestamp":1680572159000},"page":"2684","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resistance Training Increases White Matter Density in Frail Elderly Women"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-8651","authenticated-orcid":false,"given":"Marco","family":"Bucci","sequence":"first","affiliation":[{"name":"Turku PET Centre, University of Turku, 20520 Turku, Finland"},{"name":"Theme Inflammation and Aging, Karolinska University Hospital, 141 86 Huddinge, Sweden"},{"name":"Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska University, 171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Iozzo","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-5399","authenticated-orcid":false,"given":"Harri","family":"Merisaari","sequence":"additional","affiliation":[{"name":"Department of Radiology, Turku University Hospital, University of Turku, 20014 Turku, Finland"},{"name":"Turku Brain and Mind Center, University of Turku, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ville","family":"Huovinen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, 20520 Turku, Finland"},{"name":"Department of Radiology, Turku University Hospital, University of Turku, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heta","family":"Lipponen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katri","family":"R\u00e4ikk\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Logopedics, University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-315X","authenticated-orcid":false,"given":"Riitta","family":"Parkkola","sequence":"additional","affiliation":[{"name":"Department of Radiology, Turku University Hospital, University of Turku, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Salonen","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Research Centre, 00250 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Sandboge","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare, 00271 Helsinki, Finland"},{"name":"Psychology\/Welfare Sciences, Faculty of Social Sciences, University of Tampere, 33014 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Research Centre, 00250 Helsinki, Finland"},{"name":"Department of General Practice and Primary Health Care, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland"},{"name":"Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore"},{"name":"Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-9757","authenticated-orcid":false,"given":"Lauri","family":"Nummenmaa","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-338X","authenticated-orcid":false,"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, 20520 Turku, Finland"},{"name":"Department of Endocrinology, Turku University Hospital, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly 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