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Med., 10.","DOI":"10.3390\/jcm10245763"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s13054-020-03062-7","article-title":"The vascular endothelium: The cornerstone of organ dysfunction in severe SARS-CoV-2 infection","volume":"24","author":"Pons","year":"2020","journal-title":"Crit. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"701278","DOI":"10.3389\/fcimb.2021.701278","article-title":"SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Solimando, A.G., Marziliano, D., and Ribatti, D. (2022). SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows. 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Med., 10.","DOI":"10.3390\/jcm10143153"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Iwanami, Y., Ebihara, K., Nakao, K., Sato, N., Miyagi, M., Nakamura, Y., Sakamoto, S., Kishi, K., Homma, S., and Ebihara, S. (2022). Benefits of Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Drug Treatment. J. Clin. Med., 11.","DOI":"10.3390\/jcm11185336"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.apmr.2016.05.017","article-title":"Pulmonary Rehabilitation in Individuals with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review","volume":"98","author":"Lee","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_36","first-page":"CD011285","article-title":"Exercise-based rehabilitation programmes for pulmonary hypertension","volume":"1","author":"Morris","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2015.10.044","article-title":"Exercise-Based Cardiac Rehabilitation for Coronary Heart Disease: Cochrane Systematic Review and Meta-Analysis","volume":"67","author":"Anderson","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e006798","DOI":"10.1161\/CIRCHEARTFAILURE.119.006798","article-title":"Multidisciplinary Cardiac Rehabilitation and Long-Term Prognosis in Patients with Heart Failure","volume":"13","author":"Kamiya","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/eurjpc\/zwab035","article-title":"Cardiac rehabilitation and all-cause mortality in patients with heart failure: A retrospective cohort study","volume":"28","author":"Buckley","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Grochulska, A., Glowinski, S., and Bryndal, A. (2021). Cardiac Rehabilitation and Physical Performance in Patients after Myocardial Infarction: Preliminary Research. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112253"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Kim, J., Sun, B.J., Jee, S.J., and Park, J.H. (2021). Effect of Cardiac Rehabilitation on Left Ventricular Diastolic Function in Patients with Acute Myocardial Infarction. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102088"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jjcc.2021.11.011","article-title":"Comprehensive cardiac rehabilitation program for peripheral arterial diseases","volume":"80","author":"Yasu","year":"2022","journal-title":"J. Cardiol."},{"key":"ref_43","first-page":"e686","article-title":"2016 AHA\/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"135","author":"Gornik","year":"2017","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Anghel, R., Adam, C.A., Marcu, D.T.M., Mitu, O., and Mitu, F. (2022). Cardiac Rehabilitation in Patients with Peripheral Artery Disease-A Literature Review in COVID-19 Era. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020416"},{"key":"ref_45","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"ref_46","unstructured":"Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC), European Association for Cardio-Thoracic Surgery (EACTS), Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M.J., Baron-Esquivias, G., Baumgartner, H., Borger, M.A., and Carrel, T.P. (2012). Guidelines on the management of valvular heart disease (version 2012). Eur. Heart J., 33, 2451\u20132496."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kleczynski, P., Trebacz, J., Stapor, M., Sobczynski, R., Konstanty-Kalandyk, J., Kapelak, B., Zmudka, K., and Legutko, J. (2021). Inpatient Cardiac Rehabilitation after Transcatheter Aortic Valve Replacement Is Associated with Improved Clinical Performance and Quality of Life. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102125"},{"key":"ref_48","first-page":"e000922","article-title":"Exercise-based cardiac rehabilitation for patients following open surgical aortic valve replacement and transcatheter aortic valve implant: A systematic review and meta-analysis","volume":"6","author":"Anayo","year":"2019","journal-title":"Open Heart"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/8\/2847\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:15:18Z","timestamp":1760123718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/8\/2847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,13]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["jcm12082847"],"URL":"https:\/\/doi.org\/10.3390\/jcm12082847","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,4,13]]}}}