{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:46:03Z","timestamp":1792622763397,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004166","name":"Medical University of Warsaw","doi-asserted-by":"publisher","award":["MB\/M\/26(47)"],"award-info":[{"award-number":["MB\/M\/26(47)"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiac rehabilitation after acute myocardial infarction is crucial and improves patients\u2019 prognosis. It aims to optimize cardiovascular risk factors\u2019 control. Providing additional support via mobile applications has been previously suggested. However, data from prospective, randomized trials evaluating digital solutions are scarce. In this study, we aimed to evaluate a mobile application\u2014afterAMI\u2014in the clinical setting and to investigate the impact of a digitally-supported model of care in comparison with standard rehabilitation. A total of 100 patients after myocardial infarction were enrolled. Patients were randomized into groups with either a rehabilitation program and access to afterAMI or standard rehabilitation alone. The primary endpoint was rehospitalizations and\/or urgent outpatient visits after 6 months. Cardiovascular risk factors\u2019 control was also analyzed. Median age was 61 years; 65% of the participants were male. This study failed to limit the number of primary endpoint events (8% with app vs. 27% without app; p = 0.064). However, patients in the interventional group had lower NT-proBNP levels (p = 0.0231) and better knowledge regarding cardiovascular disease risk factors (p = 0.0009), despite no differences at baseline. This study showcases how a telemedical tool can be used in the clinical setting.<\/jats:p>","DOI":"10.3390\/jcm12082886","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:02:59Z","timestamp":1681696979000},"page":"2886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mobile App and Digital System for Patients after Myocardial Infarction (afterAMI): Results from a Randomized Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-870X","authenticated-orcid":false,"given":"Bartosz","family":"Krzowski","sequence":"first","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-0974","authenticated-orcid":false,"given":"Maria","family":"Boszko","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-3707","authenticated-orcid":false,"given":"Micha\u0142","family":"Peller","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7107-2134","authenticated-orcid":false,"given":"Paulina","family":"Hoffman","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"\u017burawska","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Skoczylas","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Osak","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Ko\u0142towski","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Grabowski","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-2554","authenticated-orcid":false,"given":"Grzegorz","family":"Opolski","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Balsam","sequence":"additional","affiliation":[{"name":"1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1136\/heartjnl-2014-307310","article-title":"Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations","volume":"101","author":"Degano","year":"2015","journal-title":"Heart"},{"key":"ref_3","first-page":"53","article-title":"One-year Mortality after an Acute Coronary Event and its Clinical Predictors: The ERICO Study","volume":"105","author":"Santos","year":"2015","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_5","first-page":"533","article-title":"Secondary prevention of coronary artery disease in Poland. Results from the POLASPIRE survey","volume":"27","author":"Jankowski","year":"2020","journal-title":"Cardiol. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"990","DOI":"10.33963\/KP.15465","article-title":"Observed and relative survival and 5-year outcomes of patients discharged after acute myocardial infarction: The nationwide AMI-PL database","volume":"78","author":"Wojtyniak","year":"2020","journal-title":"Kardiol. Pol."},{"key":"ref_7","first-page":"121","article-title":"Managed Care after Acute Myocardial Infarction (MC-AMI)\u2014Poland\u2019s nationwide program of comprehensive post-MI care\u2014improves prognosis in 2-year follow-up. A single high-volume center intention to treat analysis","volume":"81","author":"Wilkosz","year":"2022","journal-title":"Kardiol. Pol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.33963\/KP.a2022.0058","article-title":"Management and predictors of clinical events in 75,686 patients with acute myocardial infarction","volume":"80","author":"Jankowski","year":"2022","journal-title":"Kardiol. Pol."},{"key":"ref_9","unstructured":"(2022, October 27). How Many People Have Smartphones in 2022?. Available online: https:\/\/www.oberlo.com\/statistics\/how-many-people-have-smartphones."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.33963\/KP.15824","article-title":"Telemedicine solutions in cardiology: A joint expert opinion by the Information Technology and Telemedicine Committee of the Polish Cardiac Society, the Section of Noninvasive Electrocardiology and Telemedicine of the Polish Cardiac Society, and the Clinical Research Committee of the Polish Academy of Sciences (short version, 2021)","volume":"79","author":"Piotrowicz","year":"2021","journal-title":"Kardiol. Pol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13063-018-3118-1","article-title":"Effect of a lifestyle-focused electronic patient support application for improving risk factor management, self-rated health, and prognosis in post-myocardial infarction patients: Study protocol for a multi-center randomized controlled trial","volume":"20","author":"Gonzalez","year":"2019","journal-title":"Trials"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Alkamel, N., Jamal, A., Alnobani, O., Househ, M., Zakaria, N., Qawasmeh, M., and Tharkar, S. (2020). Understanding the stakeholders\u2019 preferences on a mobile application to reduce door to balloon time in the management of ST-elevated myocardial infarction patients\u2014A qualitative study. BMC Med. Inform. Decis. Mak., 20.","DOI":"10.1186\/s12911-020-01219-6"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ahj.2022.06.008","article-title":"Deploying a novel custom mobile application for STEMI activation and transfer in a large healthcare system to improve cross-team workflow. STEMIcathAID implementation project","volume":"253","author":"Garcia","year":"2022","journal-title":"Am. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e25224","DOI":"10.2196\/25224","article-title":"Effect of a Lifestyle-Focused Web-Based Application on Risk Factor Management in Patients Who Have Had a Myocardial Infarction: Randomized Controlled Trial","volume":"24","author":"Olsson","year":"2022","journal-title":"J. Med. Internet Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12265-015-9629-1","article-title":"Digital Health Intervention as an Adjunct to Cardiac Rehabilitation Reduces Cardiovascular Risk Factors and Rehospitalizations","volume":"8","author":"Widmer","year":"2015","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/2047487317750913","article-title":"Effectiveness, acceptability and usefulness of mobile applications for cardiovascular disease self-management: Systematic review with meta-synthesis of quantitative and qualitative data","volume":"25","author":"Coorey","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.2196\/mhealth.8352","article-title":"Mobile Technology Use Across Age Groups in Patients Eligible for Cardiac Rehabilitation: Survey Study","volume":"5","author":"Gallagher","year":"2017","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/j.hrthm.2017.03.038","article-title":"2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring\/telemetry","volume":"14","author":"Steinberg","year":"2017","journal-title":"Heart Rhythm"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s13063-022-06463-x","article-title":"Mobile app and digital system for patients after myocardial infarction (afterAMI): Study protocol for a randomized controlled trial","volume":"23","author":"Krzowski","year":"2022","journal-title":"Trials"},{"key":"ref_20","first-page":"575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"93","author":"Collet","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejphar.2014.08.009","article-title":"Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarction","volume":"742","author":"Kubica","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e059945","DOI":"10.1136\/bmjopen-2021-059945","article-title":"Efficacy, efficiency and safety of a cardiac telerehabilitation programme using wearable sensors in patients with coronary heart disease: The TELEWEAR-CR study protocol","volume":"12","author":"Antoniou","year":"2022","journal-title":"BMJ Open"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Batalik, L., Pepera, G., Papathanasiou, J., Rutkowski, S., L\u00ed\u0161ka, D., Batalikova, K., Hartman, M., Fel\u0161\u0151ci, M., and Dosbaba, F. (2021). Is the Training Intensity in Phase Two Cardiovascular Rehabilitation Different in Telehealth versus Outpatient Rehabilitation?. J. Clin. Med., 10.","DOI":"10.3390\/jcm10184069"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/CIRCULATIONAHA.121.056161","article-title":"Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome: The TEXTMEDS Randomized Clinical Trial","volume":"145","author":"Chow","year":"2022","journal-title":"Circulation"},{"key":"ref_25","first-page":"220","article-title":"Two models of early cardiac rehabilitation in male patients after myocardial infarction with preserved left ventricular function: Comparison of standard out-patient versus hybrid training programmes","volume":"69","author":"Rydzewska","year":"2011","journal-title":"Kardiol. Pol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e20468","DOI":"10.2196\/20468","article-title":"Mobile Health Intervention Promoting Physical Activity in Adults Post Cardiac Rehabilitation: Pilot Randomized Controlled Trial","volume":"5","author":"Park","year":"2021","journal-title":"JMIR Form. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1177\/2047487320905717","article-title":"Long-term follow-up with a smartphone application improves exercise capacity post cardiac rehabilitation: A randomized controlled trial","volume":"27","author":"Lunde","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/03007995.2018.1549026","article-title":"Specific hypertension smartphone application to improve medication adherence in hypertension: A cluster-randomized trial","volume":"35","year":"2019","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10198-012-0424-5","article-title":"The cost-effectiveness of smoking cessation support delivered by mobile phone text messaging: Txt2stop","volume":"14","author":"Guerriero","year":"2013","journal-title":"Eur. J. Health Econ."},{"key":"ref_30","first-page":"695","article-title":"Educating diabetic patients through an SMS intervention: A randomized controlled trial at a Brazilian public hospital","volume":"65","author":"Aceti","year":"2021","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4258\/hir.2014.20.2.117","article-title":"Development of smartphone educational application for patients with coronary artery disease","volume":"20","author":"Cho","year":"2014","journal-title":"Healthc Inform Res"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ahj.2016.05.005","article-title":"Effects of interactive patient smartphone support app on drug adherence and lifestyle changes in myocardial infarction patients: A randomized study","volume":"178","author":"Johnston","year":"2016","journal-title":"Am. Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e32554","DOI":"10.2196\/32554","article-title":"A Smartphone-Based Model of Care to Support Patients With Cardiac Disease Transitioning From Hospital to the Community (TeleClinical Care): Pilot Randomized Controlled Trial","volume":"10","author":"Indraratna","year":"2022","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0140-6736(21)01437-9","article-title":"Cardiac rehabilitation in the digital era","volume":"398","author":"Pandey","year":"2021","journal-title":"Lancet"},{"key":"ref_35","first-page":"16179","article-title":"Secondary prevention of coronary heart disease in Poland: Does sex matter? Results from the POLASPIRE survey","volume":"132","author":"Setny","year":"2022","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e000103","DOI":"10.1161\/HCQ.0000000000000103","article-title":"Harnessing Mobile Health Technology for Secondary Cardiovascular Disease Prevention in Older Adults: A Scientific Statement From the American Heart Association","volume":"14","author":"Schorr","year":"2021","journal-title":"Circ. Cardiovasc. Qual. 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