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Autonomic dysreflexia (AD), an uncontrolled rise in blood pressure in response to peripheral stimuli including common bowel routine, digital anorectal stimulation (DARS), reduces the quality of life, and increases morbidity and mortality. Recently, spinal cord stimulation (SCS) has emerged as a potential intervention to mitigate unstable blood pressure following SCI. The objective of this case series was to test the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord, the most common implant location, on mitigating AD in individuals with SCI. We recruited three individuals with cervical and upper thoracic motor-complete SCI who have an implanted epidural stimulator. We demonstrated that eSCS can reduce the elevation in blood pressure and prevent DARS-induced AD. The blood pressure variability analysis indicated that eSCS potentially reduced vascular sympathetic nervous system activity during DARS, compared to without eSCS. This case series provides evidence to support the use of eSCS to prevent AD episodes during routine bowel procedures, improving the quality of life for individuals with SCI and potentially reducing cardiovascular risks.<\/jats:p>","DOI":"10.3390\/jcm12082897","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:02:59Z","timestamp":1681696979000},"page":"2897","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Spinal Cord Stimulation Prevents Autonomic Dysreflexia in Individuals with Spinal Cord Injury: A Case Series"],"prefix":"10.3390","volume":"12","author":[{"given":"Soshi","family":"Samejima","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Shackleton","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raza N.","family":"Malik","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawami","family":"Cao","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anibal","family":"Bohorquez","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"},{"name":"Spinal Cord Program, GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-4931","authenticated-orcid":false,"given":"Tom E.","family":"Nightingale","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK"},{"name":"Centre for Trauma Sciences Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-7972","authenticated-orcid":false,"given":"Andrei V.","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 2G9, Canada"},{"name":"Spinal Cord Program, GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, BC V5Z 2G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.resp.2009.08.003","article-title":"Autonomic function following cervical spinal cord injury","volume":"169","author":"Krassioukov","year":"2009","journal-title":"Respir. 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