{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:50:25Z","timestamp":1793317825317,"version":"4.5.0"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jewish Heritage Funds","award":["K23-AA023190"],"award-info":[{"award-number":["K23-AA023190"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Hypomagnesemia has been documented in alcohol-associated liver disease (ALD). This study aims to characterize hypomagnesemia in alcoholic hepatitis (AH) patients and identify its response with liver injury and severity markers. Materials and Methods: A total of 49 male and female AH patients with an age range of 27\u201366 years were enrolled in this study. Patients were grouped by MELD: MiAH (mild AH &lt; 12 [n = 5]), MoAH (12 \u2264 moderate AH \u2264 19 [n = 13]), and SAH (severe AH \u2265 20 [n = 31]). Patients were also evaluated by MELD grouping as non-severe (MELD \u2264 19 [n = 18]) and severe (MELD \u2265 20 [n = 31]). Data were collected on demographics (Age; BMI), drinking history (AUDIT; LTDH), liver injury (ALT; AST), and liver severity (Maddrey\u2019s DF; MELD; AST:ALT). Serum magnesium (SMg) levels were tested as SOC lab (normal \u2265 0.85 \u2264 1.10 mmol\/L). Results: SMg was deficient in each group; the lowest in the MoAH patients. The true positivity of SMg values were at a good performance level when compared between severe and non-severe AH patients (AUROC: 0.695, p = 0.034). We found that the SMg level &lt; 0.78 mmol\/L could predict severe AH (sensitivity = 0.100 and 1-specificity = 0.000) at this true positivity, and subsequently analyzed patients with SMg &lt; 0.78 mmol\/L (Gr.4) and \u22650.78 mmol\/L (Gr.5). Between Gr.4 and Gr.5, there were clinically as well as statistically significant differences in disease severity as defined by MELD, Maddrey\u2019s DF, and ABIC scores. Conclusions: This study demonstrates the utility of SMg levels to identify AH patients who may have progressed to severe status. The extent of magnesium response in AH patients also corresponded significantly with the prognosis of liver disease. Physicians suspecting AH in patients with recent heavy drinking may use SMg as an indicator to guide further testing, referrals, or treatment.<\/jats:p>","DOI":"10.3390\/jcm12082968","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T02:01:11Z","timestamp":1681956071000},"page":"2968","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of Hypomagnesemia in Alcoholic Hepatitis Patients and Its Association with Liver Injury and Severity Markers"],"prefix":"10.3390","volume":"12","author":[{"given":"Evan J.","family":"Winrich","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40202, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, KY 40202, USA"},{"name":"Clinical Laboratory for Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40202, USA"},{"name":"Clinical Laboratory for Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo S.","family":"Gala","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40202, USA"},{"name":"Clinical Laboratory for Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amor J.","family":"Royer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40202, USA"},{"name":"Clinical Laboratory for Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA"},{"name":"Robley Rex Louisville VAMC, Louisville, KY 40206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipendra","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40202, USA"},{"name":"Robley Rex Louisville VAMC, Louisville, KY 40206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-6891","authenticated-orcid":false,"given":"Vatsalya","family":"Vatsalya","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, KY 40202, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, KY 40202, USA"},{"name":"Clinical Laboratory for Intervention Development of AUD and Organ Severity, University of Louisville, Louisville, KY 40202, USA"},{"name":"Robley Rex Louisville VAMC, Louisville, KY 40206, USA"},{"name":"National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gala, K.S., and Vatsalya, V. 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