{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:26:08Z","timestamp":1768011968940,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008049","name":"Banco Santander XI Convocatoria Proyectos de Investigaci\u00f3n Santander y la Universidad Alfonso X el Sabio (UAX)","doi-asserted-by":"publisher","award":["1,011,006"],"award-info":[{"award-number":["1,011,006"]}],"id":[{"id":"10.13039\/100008049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008049","name":"Banco Santander XI Convocatoria Proyectos de Investigaci\u00f3n Santander y la Universidad Alfonso X el Sabio (UAX)","doi-asserted-by":"publisher","award":["1,000,117"],"award-info":[{"award-number":["1,000,117"]}],"id":[{"id":"10.13039\/100008049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008049","name":"Banco Santander XI Convocatoria Proyectos de Investigaci\u00f3n Santander y la Universidad Alfonso X el Sabio (UAX)","doi-asserted-by":"publisher","award":["PI0012_2019"],"award-info":[{"award-number":["PI0012_2019"]}],"id":[{"id":"10.13039\/100008049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008049","name":"Banco Santander XI Convocatoria Proyectos de Investigaci\u00f3n Santander y la Universidad Alfonso X el Sabio (UAX)","doi-asserted-by":"publisher","award":["ITI PI0017-2019"],"award-info":[{"award-number":["ITI PI0017-2019"]}],"id":[{"id":"10.13039\/100008049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008049","name":"Banco Santander XI Convocatoria Proyectos de Investigaci\u00f3n Santander y la Universidad Alfonso X el Sabio (UAX)","doi-asserted-by":"publisher","award":["2020-019"],"award-info":[{"award-number":["2020-019"]}],"id":[{"id":"10.13039\/100008049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Society of Cardiology for Basic Research in Cardiology","award":["1,011,006"],"award-info":[{"award-number":["1,011,006"]}]},{"name":"Spanish Society of Cardiology for Basic Research in Cardiology","award":["1,000,117"],"award-info":[{"award-number":["1,000,117"]}]},{"name":"Spanish Society of Cardiology for Basic Research in Cardiology","award":["PI0012_2019"],"award-info":[{"award-number":["PI0012_2019"]}]},{"name":"Spanish Society of Cardiology for Basic Research in Cardiology","award":["ITI PI0017-2019"],"award-info":[{"award-number":["ITI PI0017-2019"]}]},{"name":"Spanish Society of Cardiology for Basic Research in Cardiology","award":["2020-019"],"award-info":[{"award-number":["2020-019"]}]},{"name":"European Regional Development Fund (ERDF) Integrated Territorial Initiative","award":["1,011,006"],"award-info":[{"award-number":["1,011,006"]}]},{"name":"European Regional Development Fund (ERDF) Integrated Territorial Initiative","award":["1,000,117"],"award-info":[{"award-number":["1,000,117"]}]},{"name":"European Regional Development Fund (ERDF) Integrated Territorial Initiative","award":["PI0012_2019"],"award-info":[{"award-number":["PI0012_2019"]}]},{"name":"European Regional Development Fund (ERDF) Integrated Territorial Initiative","award":["ITI PI0017-2019"],"award-info":[{"award-number":["ITI PI0017-2019"]}]},{"name":"European Regional Development Fund (ERDF) Integrated Territorial Initiative","award":["2020-019"],"award-info":[{"award-number":["2020-019"]}]},{"name":"Foundation Progreso y Salud PEER","award":["1,011,006"],"award-info":[{"award-number":["1,011,006"]}]},{"name":"Foundation Progreso y Salud PEER","award":["1,000,117"],"award-info":[{"award-number":["1,000,117"]}]},{"name":"Foundation Progreso y Salud PEER","award":["PI0012_2019"],"award-info":[{"award-number":["PI0012_2019"]}]},{"name":"Foundation Progreso y Salud PEER","award":["ITI PI0017-2019"],"award-info":[{"award-number":["ITI PI0017-2019"]}]},{"name":"Foundation Progreso y Salud PEER","award":["2020-019"],"award-info":[{"award-number":["2020-019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Recognizing symptoms in elderly patients with severe aortic stenosis (AS) can be a challenge. Serum biomarkers such as Galectin-3 or N-terminal prohormone B-type natriuretic peptide (NT-proBNP) are involved in remodeling and heart failure (HF) development and could support the diagnosis of AS. We set out to test the usefulness of NT-proBNP and Galectin-3 in predicting events in this population. We designed a prospective observational case\u2013control study, including 50 asymptomatic patients older than 70 years, diagnosed with severe degenerative AS, and 50 control individuals. The NT-proBNP and Galectin-3 levels were measured. A follow-up was carried out at 12 months to determine the occurrence of hospital admission for HF, all-cause mortality or the appearance of symptoms. The patients with severe AS had higher Galectin-3 and NT-proBNP concentrations. The area under the receiver operating characteristic curve of the NT-proBNP was 0.812 (95% CI, 0.646\u20130.832), and that of the Galectin-3 was 0.633 (95% CI, 0.711\u20130.913). NT-proBNP was a good predictor of events [HR 3.45 (95% CI 1.32\u20139.03), p = 0.011]. A Kaplan\u2013Meier analysis showed that the probability of freedom from events was significant in patients who exhibited a combination of higher NT-proBNP and Galectin-3 levels (log-rank p = 0.032). Therefore, NT-proBNP was the most reliable predictor of events in asymptomatic patients with severe AS. A combination of NT-proBNP and Galectin-3 levels may be vital in the clinical follow-up of these patients and in the decision-making process.<\/jats:p>","DOI":"10.3390\/jcm12082987","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T02:01:11Z","timestamp":1681956071000},"page":"2987","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-6152","authenticated-orcid":false,"given":"M\u00f3nica","family":"Ramos","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"},{"name":"Medicine School, Universidad Alfonso X El Sabio, Avda. De la Universidad, 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-9899","authenticated-orcid":false,"given":"Maribel","family":"Quezada-Feijo\u00f3","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"},{"name":"Medicine School, Universidad Alfonso X El Sabio, Avda. De la Universidad, 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Ayala","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"},{"name":"Medicine School, Universidad Alfonso X El Sabio, Avda. De la Universidad, 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ascensi\u00f3n","family":"Manzano","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4732-6265","authenticated-orcid":false,"given":"Francisco","family":"G\u00f3mez-Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Medicine School, Universidad Alfonso X El Sabio, Avda. De la Universidad, 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"},{"name":"Geriatric Department, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Medicine School, Universidad Alfonso X El Sabio, Avda. De la Universidad, 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"},{"name":"Geriatric Department, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Herrera","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Hospital Central de la Cruz Roja, C\/Reina Victoria, 24, 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariola","family":"L\u00f3pez Vazquez de la Torre","sequence":"additional","affiliation":[{"name":"Departmental Section of Biochemistry and Molecular Biology, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3136-1776","authenticated-orcid":false,"given":"Roc\u00edo","family":"Toro","sequence":"additional","affiliation":[{"name":"Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar University Hospital, Av\/Ana de Viya 21, 11009 C\u00e1diz, Spain"},{"name":"Medicine Department, School of Medicine, C\u00e1diz University, Edificio Andr\u00e9s Segovia 30 Floor, C\/Dr. Mara\u00f1\u00f3n S\/N, 21001 C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart survey on valvular heart disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur. 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