{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T05:59:06Z","timestamp":1772949546671,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIBERCV I","award":["CM20\/00104"],"award-info":[{"award-number":["CM20\/00104"]}]},{"name":"CIBERCV I","award":["JR22\/00004"],"award-info":[{"award-number":["JR22\/00004"]}]},{"name":"Instituto de Salud Carlos III, Spain","award":["CM20\/00104"],"award-info":[{"award-number":["CM20\/00104"]}]},{"name":"Instituto de Salud Carlos III, Spain","award":["JR22\/00004"],"award-info":[{"award-number":["JR22\/00004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular ejection fraction of &lt;40%. In total, 266 patients (45.6%) had coronary artery disease as main etiology and 137 (23.5%) had idiopathic dilated cardiomyopathy (DCM), and they are the focus of this study. Significant differences were found in Charlson index (CAD 4.4 \u00b1 2.8, idiopathic DCM 2.9 \u00b1 2.4, p &lt; 0.001), and in the number of previous hospitalizations (1.1 \u00b1 1, 0.8 \u00b1 1.2, respectively, p = 0.015). One-year mortality was similar in the two groups: idiopathic DCM (hazard ratio [HR] = 1), CAD (HR 1.50; 95% CI 0.83\u20132.70, p = 0.182). Mortality\/readmissions were also comparable: CAD (HR 0.96; 95% CI 0.64\u20131.41, p = 0.81). Patients with idiopathic DCM had a higher probability of receiving a heart transplant than those with CAD (HR 4.6; 95% CI 1.4\u201313.4, p = 0.012). The prognosis of HFrEF is similar in patients with CAD etiology and in those with idiopathic DCM. Patients with idiopathic DCM were more prone to receive heart transplant.<\/jats:p>","DOI":"10.3390\/jcm12083028","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T06:54:19Z","timestamp":1682060059000},"page":"3028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Coronary Artery Disease and Prognosis of Heart Failure with Reduced Ejection Fraction"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-9788","authenticated-orcid":false,"given":"Lourdes","family":"Vicent","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-6446","authenticated-orcid":false,"given":"Jes\u00fas","family":"\u00c1lvarez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de la Santa Creu i Sant Pau, CIBERCV, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-474X","authenticated-orcid":false,"given":"Rafael","family":"Vazquez-Garcia","sequence":"additional","affiliation":[{"name":"Cardiology Department, Puerta del Mar University Hospital, 11009 C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-3388","authenticated-orcid":false,"given":"Jos\u00e9 R.","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Santiago, CIBERCV, 15076 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Rivera","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-3416","authenticated-orcid":false,"given":"Javier","family":"Segovia","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro Majadahonda, CIBERCV, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-9540","authenticated-orcid":false,"given":"Domingo","family":"Pascual-Figal","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Virgen de la Arrixaca, Department of Medicine, University of Murcia, 30120 Murcia, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Bover","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Worner","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Fern\u00e1ndez-Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"},{"name":"Cardiology Department, Instituto de Investigaci\u00f3n, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-6656","authenticated-orcid":false,"given":"Albert","family":"Ariza-Sole","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital General, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-6229","authenticated-orcid":false,"given":"Manuel","family":"Mart\u00ednez-Sell\u00e9s","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"},{"name":"Servicio de Cardiolog\u00eda, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain"},{"name":"Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain"},{"name":"Facultad de Medicina, Universidad Europea, 28670 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics\u20142022 Update: A Report From the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.hfc.2013.10.002","article-title":"The role of coronary artery disease in heart failure","volume":"10","author":"Lala","year":"2014","journal-title":"Heart Fail. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17058","DOI":"10.1038\/nrdp.2017.58","article-title":"Heart failure with reduced ejection fraction","volume":"3","author":"Bloom","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijcard.2010.01.011","article-title":"Heart failure etiology impacts survival of patients with heart failure","volume":"149","author":"Pecini","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/eurjhf\/hfs026","article-title":"Gender and survival in patients with heart failure: Interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis","volume":"14","author":"Doughty","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.jacc.2006.11.041","article-title":"Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: A pooled analysis of 5 randomized control trials","volume":"49","author":"Frazier","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jchf.2019.02.015","article-title":"Outcomes and effect of treatment according to etiology in HFrEF: An analysis of PARADIGM-HF","volume":"7","author":"Balmforth","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0002-9149(90)91434-8","article-title":"Prognostic guides in patients with idiopathic or ischemic dilated cardiomyopathy assessed for cardiac transplantation","volume":"65","author":"Keogh","year":"1990","journal-title":"Am. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","article-title":"Idiopathic dilated cardiomyopathy","volume":"331","author":"Dec","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMoa1608029","article-title":"Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure","volume":"375","author":"Thune","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/clc.22979","article-title":"Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry","volume":"41","author":"Worner","year":"2018","journal-title":"Clin. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/imj.14289","article-title":"Discharge treatment with ACE inhibitor\/ARB after a heart failure hospitalization is associated with a better prognosis irrespectively of left ventricular ejection fraction","volume":"49","author":"Vicent","year":"2019","journal-title":"Intern. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0735-1097(01)01738-7","article-title":"A standardized definition of ischemic cardiomyopathy for use in clinical research","volume":"39","author":"Felker","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"Dilated cardiomyopathy: Genetic determinants and mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: A position statement from the european society of cardiology working group on myocardial and pericardial diseases","volume":"29","author":"Elliott","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12471-012-0285-7","article-title":"Idiopathic dilated cardiomyopathy: Possible triggers and treatment strategies","volume":"20","author":"Hazebroek","year":"2012","journal-title":"Neth. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13814788.2017.1398318","article-title":"Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands","volume":"24","author":"Kendir","year":"2018","journal-title":"Eur. J. Gen. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199209033271001","article-title":"Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial: The SAVE Investigators","volume":"327","author":"Pfeffer","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/CIRCRESAHA.118.313568","article-title":"Medical therapy for heart failure caused by ischemic heart disease","volume":"124","author":"Elgendy","year":"2019","journal-title":"Circ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1161\/CIRCULATIONAHA.105.551143","article-title":"Mortality and morbidity remain high despite captopril and\/or Valsartan therapy in elderly patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction: Results from the Valsartan in Acute Myocardial Infarction Trial (VALIANT)","volume":"112","author":"White","year":"2005","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cardfail.2006.03.010","article-title":"Validation of prognostic models among patients with advanced heart failure","volume":"12","author":"Frankel","year":"2006","journal-title":"J. Card. Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","volume":"325","author":"Yusuf","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4037\/ajcc1995.4.1.23","article-title":"Postmyocardial infarction patients: Experience from the SAVE trial","volume":"4","author":"Connors","year":"1995","journal-title":"Am. J. Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJMoa2206606","article-title":"Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction","volume":"387","author":"Perera","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1056\/NEJMoa1807365","article-title":"Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy","volume":"381","author":"Panza","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1001\/jama.290.19.2581","article-title":"Predicting mortality among patients hospitalized for heart failure: Derivation and validation of a clinical model","volume":"290","author":"Lee","year":"2003","journal-title":"JAMA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jacc.2008.04.061","article-title":"Anemia and mortality in heart failure patients a systematic review and meta-analysis","volume":"52","author":"Groenveld","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/qjmed\/hch018","article-title":"One-year follow-up of heart failure patients after their first admission","volume":"97","author":"Formiga","year":"2004","journal-title":"QJM"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.medcli.2019.03.020","article-title":"Short term prognosis of heart failure after first hospital admission","volume":"154","author":"Masip","year":"2020","journal-title":"Med. Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e1932","DOI":"10.7205\/MILMED-D-17-00017","article-title":"Repeat hospitalizations predict mortality in patients with heart failure","volume":"182","author":"Lin","year":"2017","journal-title":"Mil. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/europace\/eux089","article-title":"Implantable cardioverter defibrillator use for primary prevention in ischaemic and non-ischaemic heart disease-indications in the post-DANISH trial era: Results of the European Heart Rhythm Association survey","volume":"19","author":"Haugaa","year":"2017","journal-title":"Europace"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/europace\/euac114","article-title":"European Society of Cardiology quality indicators for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"25","author":"Aktaa","year":"2022","journal-title":"Europace"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.healun.2012.08.002","article-title":"The registry of the International Society for Heart and Lung Transplantation: 29th official adult heart transplant report","volume":"31","author":"Stehlik","year":"2012","journal-title":"J. Heart Lung Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2015.10.023","article-title":"The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update","volume":"35","author":"Mehra","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.recesp.2013.05.017","article-title":"Characteristics of patients with survival longer than 20 years following heart transplantation","volume":"66","author":"Jaramillo","year":"2013","journal-title":"Rev. Esp. Cardiol. (Engl. Ed.)"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/8\/3028\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:20:40Z","timestamp":1760124040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/8\/3028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["jcm12083028"],"URL":"https:\/\/doi.org\/10.3390\/jcm12083028","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]}}}