{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:44:24Z","timestamp":1785451464752,"version":"3.56.0"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RC2022\u20132024"],"award-info":[{"award-number":["RC2022\u20132024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Patients suffering from different forms of acute hepatic porphyria present a high risk of primary liver cancer, specifically hepatocellular carcinoma and cholangiocarcinoma, determined by the activity of the disease even though an exact mechanism of carcinogenesis has not been recognized yet. Here, we present the clinical case of a 72-year-old woman who, approximately 29 years after the diagnosis of acute intermittent porphyria, presented with intrahepatic cholangiocarcinoma with a histological diagnosis of adenocarcinoma starting from the biliary-pancreatic ducts, which was diagnosed during the clinical and anatomopathological evaluation of a pathological fracture of the femur.<\/jats:p>","DOI":"10.3390\/jcm12093091","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T06:20:42Z","timestamp":1682317242000},"page":"3091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intrahepatic Cholangiocarcinoma and Acute Intermittent Porphyria: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Claudio Carmine","family":"Guida","sequence":"first","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nardella","sequence":"additional","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Unit, \u201cPerrino\u201d Hospital, 72100 Brindisi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Latiano","sequence":"additional","affiliation":[{"name":"Division of Oncology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Crisetti","sequence":"additional","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-7635","authenticated-orcid":false,"given":"Gianluigi","family":"Mazzoccoli","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Chronobiology Laboratory, Department of Medical Sciences, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Aucella","sequence":"additional","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-7049","authenticated-orcid":false,"given":"Filippo","family":"Aucella","sequence":"additional","affiliation":[{"name":"Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy"},{"name":"Department of Medical Sciences, Division of Nephrology, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.17219\/acem\/58955","article-title":"Clinical, Biochemical and Molecular Characteristics of the Main Types of Porphyria","volume":"25","author":"Szlendak","year":"2016","journal-title":"Adv. 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