{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:14:04Z","timestamp":1776150844999,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FULBRIGHT Program"},{"name":"the Agence Nationale pour la Recherche (ANR)"},{"name":"Normandy region"},{"name":"France Alzheimer"},{"name":"FEDER"},{"name":"Caisse d\u2019Epargne Normandie Fondation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD) and Korsakoff\u2019s syndrome (KS) are two major neurocognitive disorders characterized by amnesia but AD is degenerative while KS is not. The objective is to compare regional volume deficits within the Papez circuit in AD and KS, considering AD progression. Methods: 18 KS patients, 40 AD patients (20 with Moderate AD (MAD) matched on global cognitive deficits with KS patients and 20 with Severe AD (SAD)), and 70 healthy controls underwent structural MRI. Volumes of the hippocampi, thalami, cingulate gyri, mammillary bodies (MB) and mammillothalamic tracts (MTT) were extracted. Results: For the cingulate gyri, and anterior thalamic nuclei, all patient groups were affected compared to controls but did not differ between each other. Smaller volumes were observed in all patient groups compared to controls in the mediodorsal thalamic nuclei and MB, but these regions were more severely damaged in KS than AD. MTT volumes were damaged in KS only. Hippocampi were affected in all patient groups but more severely in the SAD than in the KS and MAD. Conclusions: There are commonalities in the pattern of volume deficits in KS and AD within the Papez circuit with the anterior thalamic nuclei, cingulate cortex and hippocampus (in MAD only) being damaged to the same extent. The specificity of KS relies on the alteration of the MTT and the severity of the MB shrinkage. Further comparative studies including other imaging modalities and a neuropsychological assessment are required.<\/jats:p>","DOI":"10.3390\/jcm12093147","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:50:00Z","timestamp":1682563800000},"page":"3147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Korsakoff\u2019s Syndrome and Alzheimer\u2019s Disease\u2014Commonalities and Specificities of Volumetric Brain Alterations within Papez Circuit"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-8210","authenticated-orcid":false,"given":"Shailendra","family":"Segobin","sequence":"first","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Cyceron, Neuropsychologie et Imagerie de la M\u00e9moire Humaine (NIMH), 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Ambler","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Cyceron, Neuropsychologie et Imagerie de la M\u00e9moire Humaine (NIMH), 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-7182","authenticated-orcid":false,"given":"Alice","family":"Laniepce","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Cyceron, Neuropsychologie et Imagerie de la M\u00e9moire Humaine (NIMH), 14000 Caen, France"},{"name":"Normandie Univ, UNIROUEN, CRFDP (EA 7475), 76821 Rouen, France"},{"name":"Normandie Univ, UNICAEN, INSERM, PhIND \u201cPhysiopathology and Imaging of Neurological Disorders\u201d, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Platel","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Cyceron, Neuropsychologie et Imagerie de la M\u00e9moire Humaine (NIMH), 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gael","family":"Ch\u00e9telat","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, PhIND \u201cPhysiopathology and Imaging of Neurological Disorders\u201d, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Groussard","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, PSL Universit\u00e9 Paris, EPHE, INSERM, U1077, CHU de Caen, Cyceron, Neuropsychologie et Imagerie de la M\u00e9moire Humaine (NIMH), 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8573-9506","authenticated-orcid":false,"given":"Anne-Lise","family":"Pitel","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, PhIND \u201cPhysiopathology and Imaging of Neurological Disorders\u201d, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1176\/jnp.12.1.103-a","article-title":"Loss of Recent Memory after Bilateral Hippocampal Lesions. 1957","volume":"12","author":"Scoville","year":"2000","journal-title":"J. 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