{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:19:56Z","timestamp":1791227996758,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Beh\u00e7et\u2019s disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available. Methods: All consecutive patients in our center fulfilling the 2013 BD criteria underwent a psychometric evaluation with auto- (SCL-90-R and Modified Fatigue Index) and hetero-questionnaires (MINI). A standardized test battery assessed cognitive dysfunction. Data were correlated with BD activity as well as quality of life (SF-36). Results: We included 20 consecutive patients (16 men, four women) with a median [IQR] age of 38 (30.0\u201345.5) and a median disease duration of 7 years (1.8\u201311.0). Five patients had an abnormal brain MRI. The SCL-90-R questionnaire highlighted eight psychopathological profiles (42.1%) that correlated with altered quality of life and more severe fatigue. The most frequent symptoms were anxiety (9\/19, 47.4%), somatization (8\/19, 42.1%) and phobia (5\/19, 26.3%). Psychopathological symptoms appeared to be more severe, but not more frequent, in neuro-Beh\u00e7et\u2019s patients. Based on standardized cognitive evaluation, nine patients had cognitive impairment defined by three or more altered tests. Notably, 6\/9 patients did not have any complaint of memory loss and were thus considered ansognostic. Conclusion: Cognitive involvement was significantly associated with BD activity score (BSAS) but not with brain MRI abnormalities.<\/jats:p>","DOI":"10.3390\/jcm12093149","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:30:47Z","timestamp":1682569847000},"page":"3149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Psychiatric Symptoms and Cognitive Disorders in Beh\u00e7et\u2019s Disease: A Single-Center, Cross-Sectional Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Fanny","family":"Urbain","sequence":"first","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Faculty of Medicine, Paris Saclay University, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hardy-L\u00e9ger","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaidaa","family":"Adebs-Nasser","sequence":"additional","affiliation":[{"name":"Neuro-Imaging Department, AP-HP, Groupe Hospitalier Universitaire Paris Saclay H\u00f4pital Bic\u00eatre, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"de Menthon","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1373-8768","authenticated-orcid":false,"given":"C\u00e9cile","family":"Pivert","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Mausol\u00e9o","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Laparra","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lerolle","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Albert","family":"Domnariu","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambotte","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Faculty of Medicine, Paris Saclay University, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Immunologie des Maladies Virales et Auto-Immunes (IMVA), INSERM UMR 1184, Universit\u00e9 Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Division of Immuno-Virology, IDMIT, CEA, DSV\/iMETI, Universit\u00e9 Paris-Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Denier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Paris Saclay University, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Neurology Department, AP-HP, Groupe Hospitalier Universitaire Paris Saclay, H\u00f4pital Bic\u00eatre, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Goujard","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Faculty of Medicine, Paris Saclay University, F-94275 Le Kremlin-Bic\u00eatre, France"},{"name":"Centre d\u2019\u00e9tude en Sant\u00e9 des Populations (CESP), INSERM UMR 1018, Universit\u00e9 Paris-Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Castro-Gordon","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-617X","authenticated-orcid":false,"given":"Nicolas","family":"Noel","sequence":"additional","affiliation":[{"name":"Internal Medecine and Clinical Immunology Department, AP-HP, H\u00f4pital Bic\u00eatre, Groupe 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