{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:41:09Z","timestamp":1790862069177,"version":"4.1.0"},"reference-count":121,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","award":["PIGE-0367-2019"],"award-info":[{"award-number":["PIGE-0367-2019"]}]},{"name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","award":["RH-0048-2021"],"award-info":[{"award-number":["RH-0048-2021"]}]},{"name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","award":["PAIDI-POSTDOC-2021"],"award-info":[{"award-number":["PAIDI-POSTDOC-2021"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades de la Junta de Andaluc\u00eda","award":["PIGE-0367-2019"],"award-info":[{"award-number":["PIGE-0367-2019"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades de la Junta de Andaluc\u00eda","award":["RH-0048-2021"],"award-info":[{"award-number":["RH-0048-2021"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades de la Junta de Andaluc\u00eda","award":["PAIDI-POSTDOC-2021"],"award-info":[{"award-number":["PAIDI-POSTDOC-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nose and paranasal sinuses characterized by the presence of nasal polyps. The symptoms produced by the presence of nasal polyps such as nasal obstruction, nasal discharge, facial pain, headache, and loss of smell cause a worsening in the quality of life of patients. The source of the nasal polyps remains unclear, although it seems to be due to a chronic inflammation process in the sinonasal mucosa. Fibroblasts, the main cells in connective tissue, are intimately involved in the inflammation processes of various diseases; to this end, we carried out a systematic review to evaluate their inflammatory role in nasal polyps. Thus, we evaluated the main cytokines produced by nasal polyp-derived fibroblasts (NPDF) to assess their involvement in the production of nasal polyps and their involvement in different inflammatory pathways. The results of the review highlight the inflammatory role of NPDF through the secretion of various cytokines involved in the T1, T2, and T3 inflammatory pathways, as well as the ability of NPDF to be stimulated by a multitude of substances. With these findings, the fibroblast is positioned as a new potential therapeutic target in the treatment of CRSwNP.<\/jats:p>","DOI":"10.3390\/jcm12093280","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:08:42Z","timestamp":1683252522000},"page":"3280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Role of Fibroblasts in Chronic Inflammatory Signalling in Chronic Rhinosinusitis with Nasal Polyps\u2014A Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-1910","authenticated-orcid":false,"given":"Jos\u00e9","family":"Palacios-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Virgen Macarena, Doctor Fedriani 3, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Porras-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Campus Hospital Universitario Virgen del Roc\u00edo, Avda. Manuel Siurot s\/n, 41013 Sevilla, Spain"},{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Virgen Macarena University Hospital, University of Seville, Doctor Fedriani 3, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-0550","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Moreno-Luna","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Virgen Macarena, Doctor Fedriani 3, 41009 Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Campus Hospital Universitario Virgen del Roc\u00edo, Avda. Manuel Siurot s\/n, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3588-9095","authenticated-orcid":false,"given":"Juan","family":"Maza-Solano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Virgen Macarena, Doctor Fedriani 3, 41009 Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Campus Hospital Universitario Virgen del Roc\u00edo, Avda. Manuel Siurot s\/n, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Polo-Padillo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, University Hospital Virgen Macarena, Doctor Fedriani 3, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-8330","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mu\u00f1oz-Bravo","sequence":"additional","affiliation":[{"name":"Clinical Analysis Service, General University Hospital of Elche, Foundation for the Promotion of Health and Biomedical Research in the Valencia Region (FISABIO), Av. De Catalunya 21, 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-7821","authenticated-orcid":false,"given":"Seraf\u00edn","family":"S\u00e1nchez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Virgen Macarena, Doctor Fedriani 3, 41009 Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Campus Hospital Universitario Virgen del Roc\u00edo, Avda. Manuel Siurot s\/n, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","article-title":"Chronic Rhinosinusitis with Nasal Polyps","volume":"4","author":"Stevens","year":"2016","journal-title":"J. Allergy Clin. Immunol. 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