{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:33Z","timestamp":1787028633962,"version":"build-2736575974"},"reference-count":96,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programme d\u2019Investissements d\u2019Avenir","award":["ANR-18-RHUS-0004"],"award-info":[{"award-number":["ANR-18-RHUS-0004"]}]},{"name":"Programme d\u2019Investissements d\u2019Avenir","award":["JCT 2021"],"award-info":[{"award-number":["JCT 2021"]}]},{"name":"ERA PerMed","award":["ANR-18-RHUS-0004"],"award-info":[{"award-number":["ANR-18-RHUS-0004"]}]},{"name":"ERA PerMed","award":["JCT 2021"],"award-info":[{"award-number":["JCT 2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acute respiratory distress syndrome (ARDS) is frequently associated with sepsis. ARDS and sepsis exhibit a common pathobiology, namely excessive inflammation. Corticosteroids are powerful anti-inflammatory agents that are routinely used in septic shock and in oxygen-dependent SARS-CoV-2 related acute respiratory failure. Recently, corticosteroids were found to reduce mortality in severe community-acquired pneumonia. Corticosteroids may therefore also have a role to play in the treatment of ARDS. This narrative review was undertaken following a PubMed search for English language reports published before January 2023 using the terms acute respiratory distress syndrome, sepsis and steroids. Additional reports were identified by examining the reference lists of selected articles and based on personnel knowledge of the authors of the field. High-quality research is needed to fully understand the role of corticosteroids in the treatment of ARDS and to determine the optimal timing, dosing and duration of treatment.<\/jats:p>","DOI":"10.3390\/jcm12093340","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T01:06:28Z","timestamp":1683594388000},"page":"3340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Corticosteroids in ARDS"],"prefix":"10.3390","volume":"12","author":[{"given":"Emmanuelle","family":"Kuperminc","sequence":"first","affiliation":[{"name":"Department of Intensive Care, H\u00f4pital Raymond Poincar\u00e9, APHP University Versailles Saint Quentin-University Paris Saclay, 92380 Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Heming","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, H\u00f4pital Raymond Poincar\u00e9, APHP University Versailles Saint Quentin-University Paris Saclay, 92380 Garches, France"},{"name":"Laboratory of Infection & Inflammation\u2014U1173, School of Medicine Simone Veil, University Versailles Saint Quentin-University Paris Saclay, INSERM, 92380 Garches, France"},{"name":"FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), 92380 Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Carlos","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, H\u00f4pital Raymond Poincar\u00e9, APHP University Versailles Saint Quentin-University Paris Saclay, 92380 Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-8944","authenticated-orcid":false,"given":"Djillali","family":"Annane","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, H\u00f4pital Raymond Poincar\u00e9, APHP University Versailles Saint Quentin-University Paris Saclay, 92380 Garches, France"},{"name":"Laboratory of Infection & Inflammation\u2014U1173, School of Medicine Simone Veil, University Versailles Saint Quentin-University Paris Saclay, INSERM, 92380 Garches, France"},{"name":"FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), 92380 Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-pathol-011110-130327","article-title":"The Pathogenesis of Sepsis","volume":"6","author":"Osuchowski","year":"2011","journal-title":"Annu. 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