{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:35:29Z","timestamp":1767706529909,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre with PRELUDIUM","doi-asserted-by":"publisher","award":["2017\/27\/N\/NZ5\/02191"],"award-info":[{"award-number":["2017\/27\/N\/NZ5\/02191"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jagiellonian University Medical College","award":["2017\/27\/N\/NZ5\/02191"],"award-info":[{"award-number":["2017\/27\/N\/NZ5\/02191"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The association between chronic inflammation and depression, anxiety, anhedonia, and quality of life (QoL) has been recently emphasized. However, the pathophysiology of this relationship remains unsolved. This study aims to assess the dependence between vascular inflammation represented by eicosanoid concentration and quality of life in patients with peripheral arterial disease (PAD). A total of 175 patients undergoing endovascular treatment due to lower limbs ischemia were covered with eight years of observation after the endovascular procedure, including ankle-brachial index (ABI), color Doppler ultrasound examination, urinary leukotriene E4 (LTE4), thromboxane B2 (TXB2) and 5-Hydroxyeicosatetraenoic acid (5-HETE) measurement and quality-of-life assessment with VascuQol-6. The baseline concentrations of LTE4 and TXB2 reversely correlated with preoperative VascuQol-6 and were predictive of the postoperative values of VascuQol-6 at each follow-up. At every follow-up timepoint, the results of VascuQol-6 reflected the LTE4 and TXB2 concentrations. Higher concentrations of LTE4 and TXB2 were correlated with lower life quality during the next follow-up meeting. Changes in VascuQol-6 at eight years vs. preoperative values were reversely related to the preoperative concentrations of LTE4 and TXB2. This is the first study to confirm that changes in life quality in PAD patients undergoing endovascular treatment are highly dependent on eicosanoid-based vascular inflammation.<\/jats:p>","DOI":"10.3390\/jcm12103412","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T01:05:10Z","timestamp":1683853510000},"page":"3412","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vascular Inflammatory Markers as Predictors of Peripheral Arterial Disease Patients\u2019 Quality-of-Life Changes after Endovascular Treatment"],"prefix":"10.3390","volume":"12","author":[{"given":"Agnieszka","family":"Wachsmann-Maga","sequence":"first","affiliation":[{"name":"Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krak\u00f3w, Poland"},{"name":"Clinical Department of Angiology, University Hospital in Krak\u00f3w, 30-688 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-3692","authenticated-orcid":false,"given":"Miko\u0142aj","family":"Maga","sequence":"additional","affiliation":[{"name":"Clinical Department of Angiology, University Hospital in Krak\u00f3w, 30-688 Krak\u00f3w, Poland"},{"name":"Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romuald","family":"Polczyk","sequence":"additional","affiliation":[{"name":"Institute of Psychology, Jagiellonian University, 30-060 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"W\u0142odarczyk","sequence":"additional","affiliation":[{"name":"Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-2880","authenticated-orcid":false,"given":"Patrycja","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Jagiellonian University Medical College, 31-008 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0253-2233","authenticated-orcid":false,"given":"Karol","family":"Terlecki","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Angiology, Medical University of Lublin, 20-081 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Maga","sequence":"additional","affiliation":[{"name":"Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krak\u00f3w, Poland"},{"name":"Clinical Department of Angiology, University Hospital in Krak\u00f3w, 30-688 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2018.05.033","article-title":"Update on Peripheral Artery Disease: Epidemiology and Evidence-Based Facts","volume":"275","author":"Shu","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","article-title":"Global, Regional, and National Prevalence and Risk Factors for Peripheral Artery Disease in 2015: An Updated Systematic Review and Analysis","volume":"7","author":"Song","year":"2019","journal-title":"Lancet Glob. 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