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In addition, unlike other carrier states, Sickle Cell Trait (SCT) seems to be a risk factor for several clinical complications, such as extreme exertional injury, chronic kidney disease, and complications during pregnancy and surgery. This expert panel believes that increasing knowledge about these clinical manifestations and their prevention and management can be a useful tool for all healthcare providers involved in this issue.<\/jats:p>","DOI":"10.3390\/jcm12103441","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:02:11Z","timestamp":1684116131000},"page":"3441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Management of the Sickle Cell Trait: An Opinion by Expert Panel Members"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-6289","authenticated-orcid":false,"given":"Valeria Maria","family":"Pinto","sequence":"first","affiliation":[{"name":"Centro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, E.O. 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Membr. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1182\/blood.2019002227","article-title":"Pathologic Angiogenesis in the Bone Marrow of Humanized Sickle Cell Mice Is Reversed by Blood Transfusion","volume":"135","author":"Park","year":"2020","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ncomms1104","article-title":"Global Distribution of the Sickle Cell Gene and Geographical Confirmation of the Malaria Hypothesis","volume":"1","author":"Piel","year":"2010","journal-title":"Nat. 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Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13023-019-1099-0","article-title":"Current Challenges in the Management of Patients with Sickle Cell Disease\u2014A Report of the Italian Experience","volume":"14","author":"Russo","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_13","first-page":"2100","article-title":"Access to Emergency Department for Acute Events and Identification of Sickle Cell Disease in Refugees","volume":"19","author":"Lux","year":"2019","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/bmj.1.4857.290","article-title":"Protection Afforded by Sickle-Cell Trait Against Subtertian Malarial Infection","volume":"1","author":"Allison","year":"1954","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Williams, T.N., Mwangi, T.W., Roberts, D.J., Alexander, N.D., Weatherall, D.J., Wambua, S., Kortok, M., Snow, R.W., and Marsh, K. (2005). An Immune Basis for Malaria Protection by the Sickle Cell Trait. PLoS Med., 2.","DOI":"10.1371\/journal.pmed.0020128"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1182\/blood.V68.5.985.985","article-title":"Alpha-Thalassemia in Blacks: Genetic and Clinical Aspects and Interactions with the Sickle Hemoglobin Gene","volume":"68","author":"Steinberg","year":"1986","journal-title":"Blood"},{"key":"ref_17","unstructured":"Law on human genetic testing, German Genetic Testing Act (GenDG), Part I, N. 50, 2008: 2529."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Orth, M., Rost, I., Hoffmann, G.F., and Klein, H.-G. (2012). Practical Implementation of the German Genetic Diagnostics Act (GenDG) in Laboratory Medicine, the Human Genetics Laboratory and Genetic Counselling 1). LaboratoriumsMedizin, 35.","DOI":"10.1515\/jlm.2011.045et"},{"key":"ref_19","first-page":"695828","article-title":"Newborn Screening for Sickle Cell Disease: Technical and Legal Aspects of a German Pilot Study with 38,220 Participants","volume":"2014","author":"Brose","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpeds.2020.03.042","article-title":"Vulnerable Child Syndrome and Newborn Screening Carrier Results for Cystic Fibrosis or Sickle Cell","volume":"224","author":"Farrell","year":"2020","journal-title":"J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ajmg.c.30160","article-title":"Communication of Positive Newborn Screening Results for Sickle Cell Disease and Sickle Cell Trait: Variation across States","volume":"148C","author":"Kavanagh","year":"2008","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1001\/jama.2014.2157","article-title":"Sickle Cell Trait\u2014Neglected Opportunities in the Era of Genomic Medicine","volume":"311","author":"Taylor","year":"2014","journal-title":"JAMA"},{"key":"ref_23","first-page":"66","article-title":"Clinical Experience of Management of Thalassemia: The Sardinian Experience","volume":"33","author":"Cao","year":"1996","journal-title":"Semin. Hematol."},{"key":"ref_24","unstructured":"Cao, A., Cristina Rosatelli, M., and Galanello, R. (1996). Control of \u03b2-Thalassaemia by Carrier Screening, Genetic Counselling and Prenatal Diagnosis: The Sardinian Experience. Ciba Found Symp, 197."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/ijcp.12628","article-title":"Incidence of Haemoglobinopathies in Sicily: The Impact of Screening and Prenatal Diagnosis","volume":"69","author":"Giambona","year":"2015","journal-title":"Int. J. Clin. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12687-017-0294-8","article-title":"Voluntary Premarital Screening to Prevent Sickle Cell Disease in Jamaica: Does It Work?","volume":"8","author":"Serjeant","year":"2017","journal-title":"J. Community Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/jan.12702","article-title":"Perception of Young Adults with Sickle Cell Disease or Sickle Cell Trait about Participation in the CHOICES Randomized Controlled Trial","volume":"72","author":"Hershberger","year":"2016","journal-title":"J. Adv. Nurs."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/00913847.2020.1740628","article-title":"The Prevalence of Sickle Cell Trait in Division I University Athletics Programs","volume":"48","author":"Hirschhorn","year":"2020","journal-title":"Phys. Sportsmed."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1249\/JSR.0000000000000137","article-title":"Exercise Collapse Associated with Sickle Cell Trait (ECAST)","volume":"14","author":"Quattrone","year":"2015","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1249\/JSR.0000000000000632","article-title":"Hyponatremia Associated with Exercise versus Sickling Caused by Exercise","volume":"18","author":"Eichner","year":"2019","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1249\/JSR.0000000000000591","article-title":"Venous Thromboembolism in Ice Hockey; Progress and Challenges in Exertional Sickling","volume":"18","author":"Eichner","year":"2019","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3324\/haematol.2018.206060","article-title":"The Carrier State for Sickle Cell Disease Is Not Completely Harmless","volume":"104","author":"Xu","year":"2019","journal-title":"Haematologica"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"232596712094249","DOI":"10.1177\/2325967120942490","article-title":"Nontraumatic Exertional Fatalities in Football Players, Part 1: Epidemiology and Effectiveness of National Collegiate Athletic Association Bylaws","volume":"8","author":"Boden","year":"2020","journal-title":"Orthop. J. Sport. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"232596712094349","DOI":"10.1177\/2325967120943491","article-title":"Nontraumatic Exertional Fatalities in Football Players, Part 2: Excess in Conditioning Kills","volume":"8","author":"Boden","year":"2020","journal-title":"Orthop. J. Sport. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM198709243171301","article-title":"Sickle-Cell Trait as a Risk Factor for Sudden Death in Physical Training","volume":"317","author":"Kark","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40798-018-0131-6","article-title":"Sickle Cell Trait and Sudden Death","volume":"4","author":"Mitchell","year":"2018","journal-title":"Sport. Med.-Open"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1056\/NEJMoa1516257","article-title":"Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army Soldiers","volume":"375","author":"Nelson","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4085\/1062-6050-0400.21","article-title":"Universal Training Precautions: A Review of Evidence and Recommendations for Prevention of Exercise-Related Injury, Illness, and Death","volume":"58","author":"Nye","year":"2022","journal-title":"J. Athl. Train."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/ham.2018.0120","article-title":"Splenic Infarct on Exposure to Extreme High Altitude in Individuals with Sickle Trait: A Single-Center Experience","volume":"20","author":"Kumar","year":"2019","journal-title":"High Alt. Med. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1136\/bjsports-2012-091270","article-title":"Health Risk for Athletes at Moderate Altitude and Normobaric Hypoxia","volume":"46","author":"Schommer","year":"2012","journal-title":"Br. J. Sports Med."},{"key":"ref_41","first-page":"377","article-title":"Splenic Syndrome in Patients at High Altitude with Unrecognized Sickle Cell Trait: Splenectomy Is Often Unnecessary","volume":"48","author":"Sheikha","year":"2005","journal-title":"Can. J. Surg."},{"key":"ref_42","first-page":"223","article-title":"Sickle Cell Trait and Diving: Review and Recommendations","volume":"41","author":"Vigilante","year":"2014","journal-title":"Undersea Hyperb. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000478-199501000-00001","article-title":"Renal Medullary Carcinoma The Seventh Sickle Cell Nephropathy","volume":"19","author":"Davis","year":"1995","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/pbc.25592","article-title":"Renal Medullary Carcinoma and Sickle Cell Trait: A Systematic Review","volume":"62","author":"Alvarez","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.5858\/arpa.2017-0492-RS","article-title":"Renal Medullary Carcinoma","volume":"143","author":"Elliott","year":"2019","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJM197905033001801","article-title":"Clinical Implications of Sickle-Cell Trait and Glucose-6-Phosphate Dehydrogenase Deficiency in Hospitalized Black Male Patients","volume":"300","author":"Heller","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"ref_47","first-page":"783","article-title":"Nephropathy of Pregnancy in Women Heterozygous for Sickle Cell Disease","volume":"28","author":"Centa","year":"1976","journal-title":"Minerva Ginecol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/bjh.16518","article-title":"Pregnancy in Sickle Cell Trait: What We Do and Don\u2019t Know","volume":"190","author":"Wilson","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.ajog.2005.11.022","article-title":"Bacteriuria in Pregnant Women with Sickle Cell Trait","volume":"194","author":"Thurman","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/0009922814533418","article-title":"Sickle Cell Trait and Renal Papillary Necrosis","volume":"53","author":"Li","year":"2014","journal-title":"Clin. Pediatr. (Phila)"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1148\/113.1.59","article-title":"The Incidence and Manifestations of Urographic Papillary Abnormalities in Patients with S Hemoglobinopathies","volume":"113","author":"Eckert","year":"1974","journal-title":"Radiology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-5347(17)59255-1","article-title":"Renal Papillary Necrosis in Sickle Cell Hemoglobinopathies","volume":"115","author":"Pandya","year":"1976","journal-title":"J. Urol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1681\/ASN.2009070705","article-title":"High Prevalence of Sickle Cell Trait in African Americans with ESRD","volume":"21","author":"Derebail","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrneph.2015.8","article-title":"Sickle Cell Disease: Renal Manifestations and Mechanisms","volume":"11","author":"Nath","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1001\/jama.2014.15063","article-title":"Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans","volume":"312","author":"Naik","year":"2014","journal-title":"JAMA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/ndt\/gfq186","article-title":"Could Sickle Cell Trait Be a Predisposing Risk Factor for CKD?","volume":"25","author":"Shaw","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/bjh.14842","article-title":"Roles of APOL1 G1 and G2 Variants in Sickle Cell Disease Patients: Kidney Is the Main Target","volume":"179","author":"Kormann","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.3324\/haematol.2018.212779","article-title":"Children with Sickle Cell Anemia and APOL1 Genetic Variants Develop Albuminuria Early in Life","volume":"104","author":"Zahr","year":"2019","journal-title":"Haematologica"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/bjh.17832","article-title":"Clinical and Genetic Factors Are Associated with Kidney Complications in African Children with Sickle Cell Anaemia","volume":"196","author":"Adebayo","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-022-00540-9","article-title":"The Nephropathy of Sickle Cell Trait and Sickle Cell Disease","volume":"18","author":"Ataga","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Alladagbin, D.J., Fernandes, P.N., Tavares, M.B., Brito, J.T., Oliveira, G.G.S., Silva, L.K., Khouri, N.A., Oliveira, M.B., Amorim, T., and Matos, C.M. (2018). The Sickle Cell Trait and End Stage Renal Disease in Salvador, Brazil. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0209036"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ekir.2021.09.018","article-title":"APOL1 Renal Risk Variants and Sickle Cell Trait Associations With Reduced Kidney Function in a Large Congolese Population-Based Study","volume":"7","author":"Masimango","year":"2022","journal-title":"Kidney Int. Reports"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/bjh.15820","article-title":"Sickle Cell Trait and Renal Disease among African American U.S. Army Soldiers","volume":"185","author":"Hu","year":"2019","journal-title":"Br. J. Haematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2215\/CJN.06960520","article-title":"Acute Kidney Injury among Black Patients with Sickle Cell Trait and Sickle Cell Disease","volume":"16","author":"Olaniran","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"619","DOI":"10.7326\/M18-1161","article-title":"Clinical Outcomes Associated With Sickle Cell Trait","volume":"169","author":"Naik","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ensci.2016.02.009","article-title":"Short Term Stroke Outcome Is Worse among Individuals with Sickle Cell Trait","volume":"3","author":"Olowoyo","year":"2016","journal-title":"eNeurologicalSci"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1161\/STROKEAHA.121.036567","article-title":"Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults With and Without Sickle Cell Trait","volume":"53","author":"Wang","year":"2022","journal-title":"Stroke"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e012665","DOI":"10.1136\/bmjopen-2016-012665","article-title":"Venous Thromboembolism in Adults Screened for Sickle Cell Trait: A Population-Based Cohort Study with Nested Case\u2013Control Analysis","volume":"7","author":"Little","year":"2017","journal-title":"BMJ Open"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jth.12787","article-title":"Prospective Study of Sickle Cell Trait and Venous Thromboembolism Incidence","volume":"13","author":"Folsom","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12959-018-0179-z","article-title":"Sickle Cell Disease, Sickle Trait and the Risk for Venous Thromboembolism: A Systematic Review and Meta-Analysis","volume":"16","author":"Noubiap","year":"2018","journal-title":"Thromb. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1538-7836.2012.04697.x","article-title":"Pulmonary Embolism in Sickle Cell Disease: A Case-Control Study","volume":"10","author":"Novelli","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"897.e7","DOI":"10.1016\/j.amjmed.2006.08.015","article-title":"Deep Venous Thrombosis and Pulmonary Embolism in Hospitalized Patients with Sickle Cell Disease","volume":"119","author":"Stein","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Pintova, S., Cohen, H.W., and Billett, H.H. (2013). Sickle Cell Trait: Is There an Increased VTE Risk in Pregnancy and the Postpartum?. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064141"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.amjmed.2012.12.016","article-title":"Venous Thromboembolism in Adults with Sickle Cell Disease: A Serious and Under-Recognized Complication","volume":"126","author":"Naik","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1055\/s-0033-1361931","article-title":"Impact of Sickle Hemoglobinopathies on Pregnancy-Related Venous Thromboembolism","volume":"31","author":"Porter","year":"2013","journal-title":"Am. J. Perinatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/S0049-3848(15)50442-8","article-title":"Sickle Cell Disease and Venous Thromboembolism in Pregnancy and the Puerperium","volume":"135","author":"Noubouossie","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jpeds.2004.06.055","article-title":"Low Vitamin D Status in Children with Sickle Cell Disease","volume":"145","author":"Buison","year":"2004","journal-title":"J. Pediatr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1600-0609.2009.01333.x","article-title":"Osteopenia and Vitamin D Deficiency in Children with Sickle Cell Disease","volume":"83","author":"Chapelon","year":"2009","journal-title":"Eur. J. Haematol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ajh.21085","article-title":"Sickle Cell Bone Disease: Response to Vitamin D and Calcium","volume":"83","author":"Adewoye","year":"2008","journal-title":"Am. J. Hematol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ajh.22247","article-title":"Pituitary Iron and Volume Predict Hypogonadism in Transfusional Iron Overload","volume":"87","author":"Noetzli","year":"2012","journal-title":"Am. J. Hematol."},{"key":"ref_81","first-page":"332","article-title":"Prevalence of Vitamin D Deficiency in Adults With Sickle Cell Disease","volume":"102","author":"Goodman","year":"2010","journal-title":"J. Natl. Med. Assoc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ajh.20541","article-title":"High Prevalence and Correlates of Low Bone Mineral Density in Young Adults with Sickle Cell Disease","volume":"81","author":"Miller","year":"2006","journal-title":"Am. J. Hematol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bone.2018.02.003","article-title":"High Bone Mineral Density in Sickle Cell Disease: Prevalence and Characteristics","volume":"110","author":"Ranque","year":"2018","journal-title":"Bone"},{"key":"ref_84","first-page":"776","article-title":"Semiological Profile of Avascular Necrosis of the Femoral Head in Patients with AA and AS Hemoglobins","volume":"87","author":"Oniankitan","year":"2009","journal-title":"Tunis. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0002-9343(78)90458-8","article-title":"The Morbidity of Sickle Cell Trait","volume":"64","author":"Sears","year":"1978","journal-title":"Am. J. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1302\/0301-620X.74B3.1587879","article-title":"Hip Arthroplasty in Patients with Sickle-Cell Haemoglobinopathy","volume":"74-B","author":"Acurio","year":"1992","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_87","first-page":"527","article-title":"Ischemic Necrosis of Bone in Sickle Cell Trait","volume":"41","author":"Nachamie","year":"1974","journal-title":"Mt. Sinai. J. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.otsr.2009.01.001","article-title":"Sickle-Cell Hip Necrosis and Intraosseous Pressure","volume":"95","author":"Mukisi","year":"2009","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/rheumatology\/25.1.34","article-title":"Aseptic Necrosis of the Femoral Head in Sickle-Cell Disease","volume":"25","author":"Ebong","year":"1986","journal-title":"Rheumatology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2106\/00004623-198870040-00004","article-title":"Osteonecrosis of the Hip in the Sickle-Cell Diseases. Treatment and Complications","volume":"70","author":"Hanker","year":"1988","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3851\/IMP1398","article-title":"Avascular Osteonecrosis of the Femoral Head in Three West African HIV-Infected Adults with Heterozygous Sickle Cell Disease","volume":"14","author":"Ouiminga","year":"2009","journal-title":"Antivir. Ther."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jor.2019.11.038","article-title":"Total Hip Arthroplasty: Concerns and Precautions in Sickle-Cell Trait","volume":"18","author":"Pisanu","year":"2020","journal-title":"J. Orthop."},{"key":"ref_93","first-page":"643","article-title":"Osteonecrosis in Sickle Cell Trait","volume":"13","author":"Taylor","year":"1986","journal-title":"J. Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"299","DOI":"10.7326\/0003-4819-57-2-299","article-title":"Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)","volume":"57","author":"Ratcliff","year":"1962","journal-title":"Ann. Intern. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/rheumatology\/17.2.113","article-title":"Avascular Necrosis of the Femoral Head in Sickle Cell Trait","volume":"17","author":"Perumal","year":"1978","journal-title":"Rheumatology"},{"key":"ref_96","first-page":"227","article-title":"Aseptic Necrosis of the Femoral Heads Occurring in Sickle Cell Trait: A Case Report","volume":"29","author":"Greenfield","year":"1970","journal-title":"Chic. Med. Sch. Q."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJM197402212900807","article-title":"Avascular Necrosis and Erythrocytosis in Sickle-Cell Trait","volume":"290","author":"Keeling","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1365-2044.2010.06353.x","article-title":"Intra-Operative Cell Salvage and Sickle Cell Carrier Status","volume":"65","author":"Hulatt","year":"2010","journal-title":"Anaesthesia"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/00000542-198905000-00032","article-title":"Use of the Cell Saver in Patients with Sickle Cell Trait","volume":"70","author":"Brajtbord","year":"1989","journal-title":"Anesthesiology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijoa.2008.06.010","article-title":"Use of Cell Salvage in Patients with Sickle Cell Trait","volume":"18","author":"Okunuga","year":"2009","journal-title":"Int. J. Obstet. Anesth."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00000542-198805000-00042","article-title":"Autologous Blood Transfusion in Patients with Sickle Cell Trait","volume":"68","author":"Romanoff","year":"1988","journal-title":"Anesthesiology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/tri.13268","article-title":"Intra-Operative Cell Salvage and Sickle Cell Trait in Liver Transplantation: Time to Reconsider?","volume":"31","author":"Loh","year":"2018","journal-title":"Transpl. Int."},{"key":"ref_103","unstructured":"(2023, February 01). Repertorio Atti n. 231\/CSR Del 30 Novembre 2022). (23A00090) (GU Serie Generale n.10 Del 13-01-2023). Available online: https:\/\/www.statoregioni.it\/it\/conferenza-stato-regioni\/sedute-2022\/seduta-del-30112022\/atti\/repertorio-atto-n-231csr\/."},{"key":"ref_104","unstructured":"Kort, P. (2023, February 01). Haemoglobin Disorder. Available online: https:\/\/share.wmda.info\/display\/DMSR\/Haemoglobin+disorder."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1182\/blood.V99.3.850","article-title":"Mobilization, Collection, and Processing of Peripheral Blood Stem Cells in Individuals with Sickle Cell Trait","volume":"99","author":"Kang","year":"2002","journal-title":"Blood"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/bmt.2014.252","article-title":"Safety of Stem Cell Mobilization in Donors with Sickle Cell Trait","volume":"50","author":"Dennison","year":"2015","journal-title":"Bone Marrow Transplant."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1056\/NEJMoa0904971","article-title":"Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease","volume":"361","author":"Hsieh","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1423-0410.2012.01632.x","article-title":"Safety and Efficacy of Healthy Volunteer Stem Cell Mobilization with Filgrastim G-CSF and Mobilized Stem Cell Apheresis: Results of a Prospective Longitudinal 5-Year Follow-up Study","volume":"104","author":"Mueller","year":"2013","journal-title":"Vox Sang."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ajh.2830100309","article-title":"Freeze Preservation of Sickle Erythrocytes","volume":"10","author":"Castro","year":"1981","journal-title":"Am. J. Hematol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1046\/j.1537-2995.1976.16677060246.x","article-title":"Freezing and Deglycerolizing Sickle-Trait Red Blood Cells","volume":"16","author":"Meryman","year":"1976","journal-title":"Transfusion"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1182\/blood.V97.10.3313","article-title":"Fatal Sickle Cell Crisis after Granulocyte Colony-Stimulating Factor Administration","volume":"97","author":"Adler","year":"2001","journal-title":"Blood"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/trf.13551","article-title":"Hematopoietic Progenitor Cell Mobilization Is More Robust in Healthy African American Compared to Caucasian Donors and Is Not Affected by the Presence of Sickle Cell Trait","volume":"56","author":"Panch","year":"2016","journal-title":"Transfusion"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1432-2277.2007.00611.x","article-title":"Screening for Sickle Trait among Potential Live Kidney Donors: Policies and Practices in US Transplant Centers","volume":"21","author":"Reese","year":"2008","journal-title":"Transpl. Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6002\/ect.2011.0098","article-title":"Sickle Cell and Renal Transplant: A National Survey and Literature Review","volume":"10","author":"Nath","year":"2012","journal-title":"Exp. Clin. Transplant."},{"key":"ref_115","first-page":"698","article-title":"Kidney Transplant from Sickle Cell Trait Donor to Sickle Cell Trait Recipient","volume":"5","author":"Kelta","year":"2007","journal-title":"Exp. Clin. Transplant."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/ajt.14063","article-title":"Kidney Transplantation from a Donor with Sickle Cell Disease","volume":"17","author":"Rossidis","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e14626","DOI":"10.1111\/ctr.14626","article-title":"Outcomes of Kidney Donors with Sickle Cell Trait: A Preliminary Analysis","volume":"36","author":"Hebert","year":"2022","journal-title":"Clin. Transplant."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0090-4295(78)90131-0","article-title":"Sickle Cell Trait: Possible Contributory Cause of Renal Allograft Failure","volume":"11","author":"Chatterjee","year":"1978","journal-title":"Urology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4103\/0971-4065.78066","article-title":"Acute Cortical Necrosis Following Renal Transplantation in a Case of Sickle Cell Trait","volume":"21","author":"Jha","year":"2011","journal-title":"Indian J. Nephrol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000181781","article-title":"National Study on Natural History of Renal Allografts in Sickle Cell Disease or Trait","volume":"25","author":"Chatterjee","year":"1980","journal-title":"Nephron"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0022-3468(80)80001-7","article-title":"Perioperative Management of Children with Sickle Hemoglobinopathy","volume":"15","author":"Janik","year":"1980","journal-title":"J. Pediatr. Surg."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00007611-198601000-00009","article-title":"Cholelithiasis in Sickle Cell Anemia","volume":"79","author":"Rutledge","year":"1986","journal-title":"S. Med. J."},{"key":"ref_123","first-page":"27","article-title":"Anesthesia for Sickle Cell Diseases and Other Hemoglobinopathies","volume":"4","author":"Gibson","year":"1987","journal-title":"Sem Anesth."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00000658-198807000-00003","article-title":"Elective Cholecystectomy in Children with Sickle Hemoglobinopathies","volume":"208","author":"Ware","year":"1988","journal-title":"Ann. Surg."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF03010861","article-title":"Sickle Cell States and the Anaesthetist","volume":"35","author":"Esseltine","year":"1988","journal-title":"Can. J. Anaesth."},{"key":"ref_126","first-page":"2","article-title":"Kidney Transplantation in a Patient with Sickle Cell Kidney Disease?","volume":"3","author":"Bihl","year":"2002","journal-title":"Medscape Transplant."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.humpath.2010.09.013","article-title":"Intragraft Vascular Occlusive Sickle Crisis with Early Renal Allograft Loss in Occult Sickle Cell Trait","volume":"42","author":"Kim","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1111\/ajt.15379","article-title":"Catastrophic Sickling Crisis in Patient Undergoing Cardiac Transplantation with Sickle Cell Trait","volume":"19","author":"Ali","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/tbj.12875","article-title":"Autologous Breast Reconstruction in Sickle Cell Trait: A Fine Line between Success & Failure","volume":"24","author":"Hoornweg","year":"2018","journal-title":"Breast J."},{"key":"ref_130","first-page":"53,54,96","article-title":"Raccomandazioni per la Gestione del Paziente Adulto Affetto da Anemia Falciforme: Della Societ\u00e0 Italiana Talassemie Ed Emoglobinopatie-SITE","volume":"2","author":"Graziadei","year":"2014","journal-title":"Collana Sci. S.I.T.E."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ajh.20755","article-title":"Physical Fitness Indices and Anthropometrics Profiles in Schoolchildren with Sickle Cell Trait\/Disease","volume":"82","author":"Moheeb","year":"2007","journal-title":"Am. J. Hematol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ebiom.2016.11.011","article-title":"Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation","volume":"14","author":"Goheen","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/14767058.2018.1510912","article-title":"Description of Criteria for near Miss in High-Complexity Obstetric Population with Sickle Cell Anemia: An Observational Study","volume":"33","year":"2020","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1111\/trf.14767","article-title":"Improvement of Maternal and Fetal Outcomes in Women with Sickle Cell Disease Treated with Early Prophylactic Erythrocytapheresis","volume":"58","author":"Vianello","year":"2018","journal-title":"Transfusion"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejim.2017.04.018","article-title":"Clinical Management of Iron Deficiency Anemia in Adults: Systemic Review on Advances in Diagnosis and Treatment","volume":"42","author":"Iolascon","year":"2017","journal-title":"Eur. J. Intern. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1111\/j.1742-1241.2010.02451.x","article-title":"Maternal and Perinatal Outcomes amongst Haemoglobinopathy Carriers: A Systematic Review","volume":"64","author":"Jans","year":"2010","journal-title":"Int. J. Clin. Pract."},{"key":"ref_137","first-page":"986","article-title":"Pregnancy Outcomes among Palestinian Refugee Women with Sickle Cell Trait in Damascus, Syria","volume":"24","author":"Abdulsalam","year":"2003","journal-title":"Saudi. Med. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0002-9378(97)70209-6","article-title":"Women with Sickle Cell Trait Are at Increased Risk for Preeclampsia","volume":"177","author":"Larrabee","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/01.AOG.0000285995.41769.83","article-title":"Perinatal and Maternal Outcomes in Women With Sickle or Hemoglobin C Trait","volume":"110","author":"Tita","year":"2007","journal-title":"Obstet. Gynecol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.ajog.2006.02.027","article-title":"Pregnancy Loss after First-Trimester Viability in Women with Sickle Cell Trait: Time for a Reappraisal?","volume":"194","author":"Taylor","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e346","DOI":"10.1055\/s-0039-1695743","article-title":"Adverse Pregnancy Outcomes in Women with Sickle Cell Trait","volume":"9","author":"Wellenstein","year":"2019","journal-title":"Am. J. Perinatol. Reports"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1471-0528.2008.01776.x","article-title":"Birthweights in Sickle Cell Trait Pregnancies","volume":"115","author":"Tan","year":"2008","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"key":"ref_143","first-page":"28610","article-title":"Sickle Cell Trait and Adverse Pregnancy Outcomes: Is There a Link?","volume":"14","author":"Buhusayyen","year":"2022","journal-title":"Cureus"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1080\/14767058.2019.1671333","article-title":"Inpatient Mortality and Postpartum Readmission Rates in Sickle Cell Disease Pregnancies: A Multistate Analysis, 2007\u20132014","volume":"34","author":"Bae","year":"2021","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"620.e1","DOI":"10.1016\/j.ajog.2009.01.038","article-title":"Hormonal Contraception, Sickle Cell Trait, and Risk for Venous Thromboembolism among African American Women","volume":"200","author":"Austin","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0002-9394(14)71127-4","article-title":"Sickle Cell Trait as a Risk Factor for Secondary Hemorrhage in Children With Traumatic Hyphema","volume":"123","author":"Nasrullah","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1442-9071.2006.01227.x","article-title":"Complicated Hyphaema: Think Sickle","volume":"34","author":"Hooper","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/milmed\/164.3.230","article-title":"Splenic Syndrome in Sickle Cell Trait: Fourcase Presentations and a Review of the Literature","volume":"164","author":"Franlin","year":"1999","journal-title":"Mil. Med."},{"key":"ref_149","first-page":"181","article-title":"Exercise and Hemoglobin S","volume":"31","author":"Kark","year":"1994","journal-title":"Semin. Hematol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/EDE.0b013e3181d61af8","article-title":"Sickle Cell Trait, Hemoglobin C Trait, and Invasive Pneumococcal Disease","volume":"21","author":"Poehling","year":"2010","journal-title":"Epidemiology"},{"key":"ref_151","unstructured":"Casale, M., De Franceschi, L., Balocco, M., Graziadei, G., Palazzi, G., Perrotta, S., Pinto, V., Rigano, P., Russo, G., and Sainati, L. (2018, November 01). Gestione Del Rischio Infettivo Nel Paziente Splenectomizzato o Con Asplenia Funzionale. Available online: http:\/\/site-italia.org\/download.php?file=Management_Asplenici.pdf."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100911","DOI":"10.1016\/j.blre.2021.100911","article-title":"Clinical Outcomes of COVID-19 in Patients with Sickle Cell Disease and Sickle Cell Trait: A Critical Appraisal of the Literature","volume":"53","author":"Hoogenboom","year":"2022","journal-title":"Blood Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.83.24.9363","article-title":"Hemoglobin S Antilles: A Variant with Lower Solubility than Hemoglobin S and Producing Sickle Cell Disease in Heterozygotes","volume":"83","author":"Monplaisir","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1056\/NEJM199110173251607","article-title":"Sickle Cell Disease in a Patient with Sickle Cell Trait and Compound Heterozygosity for Hemoglobin S and Hemoglobin Quebec\u2013Chori","volume":"325","author":"Witkowska","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1182\/blood-2010-05-284331","article-title":"Sickle Cell Disease Resulting from Uniparental Disomy in a Child Who Inherited Sickle Cell Trait","volume":"116","author":"Swensen","year":"2010","journal-title":"Blood"},{"key":"ref_156","unstructured":"Bain, B. (2008). Haemoglobinopathy Diagnosis, Wiley Blackwell Publishing Ltd.. [2nd ed.]."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.3109\/07420528.2013.804083","article-title":"Intraday Blood Rheological Changes Induced by Ramadan Fasting in Sickle Cell Trait Carriers","volume":"30","author":"Diaw","year":"2013","journal-title":"Chronobiol. Int."},{"key":"ref_158","unstructured":"Embury, S., Hebbel, R., Mohandas, N., and Steinberg, M. (1994). Sickle Cell Disease: Basic Principles and Clinical Practice, Raven Press."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/CIRCULATIONAHA.109.882464","article-title":"Open Heart Surgery in Patients With Sickle Cell Hemoglobinopathy","volume":"121","author":"Yousafzai","year":"2010","journal-title":"Circulation"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1053\/j.jvca.2004.07.032","article-title":"Pro: Exchange Transfusion Is Required for Sickle Cell Trait Patients Undergoing Cardiopulmonary Bypass","volume":"18","author":"Hemming","year":"2004","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1182\/asheducation-2005.1.58","article-title":"An Evidence-Based Approach to the Treatment of Adults with Sickle Cell Disease","volume":"2005","author":"Lottenberg","year":"2005","journal-title":"Hematology"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jama.2014.10517","article-title":"Management of Sickle Cell Disease","volume":"312","author":"Yawn","year":"2014","journal-title":"JAMA"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/icvts\/ivu249","article-title":"Hypothermic Cardiopulmonary Bypass without Exchange Transfusion in Sickle-Cell Patients: A Matched-Pair Analysis","volume":"19","author":"Edwin","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1540-8191.2010.01102.x","article-title":"Preoperative Exchange Transfusion for Sickle Cell Disease Patients Undergoing Open-Heart Surgery: An Exception to the Rule","volume":"25","author":"Adhikari","year":"2010","journal-title":"J. Card. Surg."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1111\/jocs.17145","article-title":"Single-center Experience of LVAD Implantation in Patients with Sickle-cell Trait: A Retrospective Analysis","volume":"37","author":"Khamees","year":"2022","journal-title":"J. Card. Surg."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/jama.1974.03230460028015","article-title":"The Sickle Cell Trait and Surgical Complications. A Matched-Pair Patient Analysis","volume":"229","author":"Atlas","year":"1974","journal-title":"JAMA"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/thx.37.7.486","article-title":"Open-Heart Surgery in Sickle-Cell Haemoglobinopathies: Report of 15 Cases","volume":"37","author":"Metras","year":"1982","journal-title":"Thorax"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3441\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:34:10Z","timestamp":1760124850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":167,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jcm12103441"],"URL":"https:\/\/doi.org\/10.3390\/jcm12103441","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]}}}