{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:16:37Z","timestamp":1768403797276,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Palliative surgery is performed to improve the quality of life of patients with spinal metastases. However, it is sometimes difficult to achieve the expected results because the patient\u2019s condition, and risk factors related to poor outcomes have not been well elucidated. This study aimed to evaluate the functional outcomes and investigate the risk factors for poor outcomes after palliative surgery for spinal metastasis. We retrospectively reviewed the records of 117 consecutive patients who underwent palliative surgery for spinal metastases. Neurological and ambulatory statuses were evaluated pre- and post-operatively. Poor outcomes were defined as no improvement or deterioration in functional status or early mortality, and the related risk factors were analyzed using multivariate logistic regression analysis. The results showed neurological improvement in 48% and ambulatory improvement in 70% of the patients with preoperative impairment, whereas 18% of the patients showed poor outcomes. In the multivariate analysis, low hemoglobin levels and low revised Tokuhashi scores were identified as risk factors for poor outcomes. The present results suggest that anemia and low revised Tokuhashi scores are related not only to life expectancy but also to functional recovery after surgery. Treatment options should be carefully selected for the patients with these factors.<\/jats:p>","DOI":"10.3390\/jcm12103442","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:02:11Z","timestamp":1684116131000},"page":"3442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for Poor Outcome after Palliative Surgery for Metastatic Spinal Tumors"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-9226","authenticated-orcid":false,"given":"Akinobu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-3363","authenticated-orcid":false,"given":"Hidetomi","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minori","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-0046","authenticated-orcid":false,"given":"Hiromitsu","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-2599","authenticated-orcid":false,"given":"Koji","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hernandez, R.K., Wade, S.W., Reich, A., Pirolli, M., Liede, A., and Lyman, G.H. (2018). Incidence of Bone Metastases in Patients with Solid Tumors: Analysis of Oncology Electronic Medical Records in the United States. BMC Cancer, 18.","DOI":"10.1186\/s12885-017-3922-0"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/bjc.1965.3","article-title":"Secondary Malignant Disease of Bone","volume":"19","author":"Clain","year":"1965","journal-title":"Br. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","article-title":"Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression Caused by Metastatic Cancer: A Randomised Trial","volume":"366","author":"Patchell","year":"2005","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/cncr.28497","article-title":"Effect of a Randomized Controlled Trial on the Surgical Treatment of Spinal Metastasis, 2000 through 2010: A Population-Based Cohort Study","volume":"120","author":"Kelly","year":"2014","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3340\/jkns.2020.0330","article-title":"Epidemiologic Study of Operative Treatment for Spinal Metastasis in Thailand: A Review of National Healthcare Data from 2005 to 2014","volume":"65","author":"Luksanapruksa","year":"2021","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1055\/s-0039-1694698","article-title":"Interventional Oncology: Management of Non-Liver Malignancies: Percutaneous Interventional Management of Spinal Metastasis","volume":"36","author":"Lee","year":"2019","journal-title":"Semin. Interv. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10585-019-10016-z","article-title":"Impact of Decompressive Laminectomy on the Functional Outcome of Patients with Metastatic Spinal Cord Compression and Neurological Impairment","volume":"37","author":"Younsi","year":"2020","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1016\/j.wneu.2020.12.130","article-title":"Minimal Invasive Surgery Instrumented Fusion versus Conventional Open Surgical Instrumented Fusion for the Treatment of Spinal Metastases: A Systematic Review and Meta-Analysis","volume":"148","author":"Pranata","year":"2021","journal-title":"World Neurosurg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"B14","DOI":"10.1097\/BRS.0000000000001811","article-title":"Minimally Invasive Pedicle Screws Fixation and Percutaneous Vertebroplasty for the Surgical Treatment of Thoracic Metastatic Tumors With Neurologic Compression","volume":"41","author":"Gu","year":"2016","journal-title":"Spine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1097\/BSD.0000000000001342","article-title":"Comparative Study of Circumferential Decompression and Posterior Decompression in Palliative Surgery for Metastatic Thoracic Spinal Tumors","volume":"35","author":"Otsuki","year":"2022","journal-title":"Clin. Spine Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E1026","DOI":"10.1097\/BSD.0000000000000456","article-title":"Prospective Cohort Study of Performance Status and Activities of Daily Living After Surgery for Spinal Metastasis","volume":"30","author":"Kakutani","year":"2017","journal-title":"Clin. Spine Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/cncr.11039","article-title":"Clinical Outcome and Survival after Palliative Surgery for Spinal Metastases: Palliative Surgery in Spinal Metastases","volume":"97","author":"Hirabayashi","year":"2003","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.amjmed.2003.12.008","article-title":"Prevalence and Outcomes of Anemia in Cancer: A Systematic Review of the Literature","volume":"116","author":"Knight","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1475-2891-9-69","article-title":"Pretreatment Serum Albumin as a Predictor of Cancer Survival: A Systematic Review of the Epidemiological Literature","volume":"9","author":"Gupta","year":"2010","journal-title":"Nutr. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.spinee.2018.03.011","article-title":"Predicting Survival for Metastatic Spine Disease: A Comparison of Nine Scoring Systems","volume":"18","author":"Ahmed","year":"2018","journal-title":"Spine J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1097\/01.brs.0000180401.06919.a5","article-title":"A Revised Scoring System for Preoperative Evaluation of Metastatic Spine Tumor Prognosis","volume":"30","author":"Tokuhashi","year":"2005","journal-title":"Spine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2106\/JBJS.15.00975","article-title":"Development of a Prognostic Survival Algorithm for Patients with Metastatic Spine Disease","volume":"98","author":"Pereira","year":"2016","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/17453679508995508","article-title":"Survival after Surgery for Spinal and Extremity Metastases. Prognostication in 241 Patients","volume":"66","author":"Bauer","year":"1995","journal-title":"Acta Orthop. Scand."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","article-title":"A Novel Classification System for Spinal Instability in Neoplastic Disease: An Evidence-Based Approach and Expert Consensus from the Spine Oncology Study Group","volume":"35","author":"Fisher","year":"2010","journal-title":"Spine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1007\/s00586-020-06396-6","article-title":"Prospective Analysis of Health-Related Quality of Life after Surgery for Spinal Metastases","volume":"29","author":"Quraishi","year":"2020","journal-title":"Eur. Spine J."},{"key":"ref_22","first-page":"179","article-title":"The Value of Postural Reduction in the Initial Management of Closed Injuries of the Spine with Paraplegia and Tetraplegia. I","volume":"7","author":"Frankel","year":"1969","journal-title":"Paraplegia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1302\/0301-620X.102B12.BJJ-2020-0566.R1","article-title":"Prospective Cohort Study of Surgical Outcome for Spinal Metastases in Patients Aged 70 years or Older","volume":"102","author":"Kanda","year":"2020","journal-title":"Bone Jt. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1227\/NEU.0000000000000907","article-title":"Prediction of Quality of Life and Survival after Surgery for Symptomatic Spinal Metastases: A Multicenter Cohort Study to Determine Suitability for Surgical Treatment","volume":"77","author":"Choi","year":"2015","journal-title":"Neurosurgery"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1002\/cncr.32420","article-title":"Association of Neurologic Deficits with Surgical Outcomes and Health-Related Quality of Life after Treatment for Metastatic Epidural Spinal Cord Compression","volume":"125","author":"Barzilai","year":"2019","journal-title":"Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e278","DOI":"10.1016\/j.wneu.2018.04.188","article-title":"Prognostic Factors of Ambulatory Status for Patients with Metastatic Spinal Cord Compression: A Systematic Review and Meta-Analysis","volume":"116","author":"Liu","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/cam4.292","article-title":"New Prognostic Factors and Scoring System for Patients with Skeletal Metastasis","volume":"3","author":"Katagiri","year":"2014","journal-title":"Cancer Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e154943","DOI":"10.1172\/JCI154943","article-title":"Targeting Mutations in Cancer","volume":"132","author":"Waarts","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejca.2020.02.038","article-title":"Tumour Mutational Burden as a Biomarker for Immunotherapy: Current Data and Emerging Concepts","volume":"131","author":"Fumet","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1158\/1535-7163.MCT-19-0993","article-title":"Patient Selection Strategies to Maximize Therapeutic Index of Antibody\u2013Drug Conjugates: Prior Approaches and Future Directions","volume":"19","author":"Williams","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00007632-199011010-00005","article-title":"Scoring System for the Preoperative Evaluation of Metastatic Spine Tumor Prognosis","volume":"15","author":"Tokuhashi","year":"1990","journal-title":"Spine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3171\/2020.12.SPINE201741","article-title":"Are Spine Metastasis Survival Scoring Systems Outdated and Do They Underestimate Life Expectancy? Caution in Surgical Recommendation Guidance","volume":"35","author":"Tabourel","year":"2021","journal-title":"J. Neurosurg. Spine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1007\/s00586-021-06954-6","article-title":"Prognostic Scores for Survival as Decisional Support for Surgery in Spinal Metastases: A Performance Assessment Systematic Review","volume":"30","author":"Smeijers","year":"2021","journal-title":"Eur. Spine J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1097\/BRS.0b013e3181878733","article-title":"Changes in Physical Function after Palliative Surgery for Metastatic Spinal Tumor: Association of the Revised Tokuhashi Score with Neurologic Recovery","volume":"33","author":"Yamashita","year":"2008","journal-title":"Spine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1097\/BRS.0b013e318188b98f","article-title":"Tokuhashi Prognosis Score: An Important Tool in Prediction of the Neurological Outcome in Metastatic Spinal Cord Compression?: A Retrospective Clinical Study","volume":"33","author":"Putz","year":"2008","journal-title":"Spine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/sc.2016.145","article-title":"Preoperative Prediction for Regaining Ambulatory Ability in Paretic Non-Ambulatory Patients with Metastatic Spinal Cord Compression","volume":"55","author":"Ohashi","year":"2017","journal-title":"Spinal Cord"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2257.2004.00664.x","article-title":"The Impact of Anaemia on Outcome in Cancer","volume":"27","author":"Clarke","year":"2005","journal-title":"Clin. Lab. Haematol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Huang, Y., Wei, S., Jiang, N., Zhang, L., Wang, S., Cao, X., Zhao, Y., and Wang, P. (2018). The Prognostic Impact of Decreased Pretreatment Haemoglobin Level on the Survival of Patients with Lung Cancer: A Systematic Review and Meta-Analysis. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-5136-5"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1016\/j.clgc.2019.12.002","article-title":"Prognostic Value of Hemoglobin in Metastatic Hormone-Sensitive Prostate Cancer: A Systematic Review and Meta-Analysis","volume":"18","author":"Mori","year":"2020","journal-title":"Clin. Genitourin. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Yang, M., Ma, X., Wang, P., Yang, J., Zhong, N., Liu, Y., Shen, J., Wan, W., Jiao, J., and Xu, W. (Global Spine J., 2022). Prediction of Survival Prognosis for Spinal Metastasis from Cancer of Unknown Primary: Derivation and Validation of a Nomogram Model, Global Spine J., in press.","DOI":"10.1177\/21925682221103833"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1385\/MO:18:4:243","article-title":"Treatment Resistance of Solid Tumors: Role of Hypoxia and Anemia","volume":"18","author":"Vaupel","year":"2001","journal-title":"Med. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/cncr.10245","article-title":"Fatigue in Cancer Patients Compared with Fatigue in the General United States Population","volume":"94","author":"Cella","year":"2002","journal-title":"Cancer"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:34:12Z","timestamp":1760124852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,13]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jcm12103442"],"URL":"https:\/\/doi.org\/10.3390\/jcm12103442","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,13]]}}}