{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:08:07Z","timestamp":1789502887417,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI Grant-in-Aid for Scientific Research (C)","doi-asserted-by":"publisher","award":["16KT0190"],"award-info":[{"award-number":["16KT0190"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japanese Foundation for Research and Promotion of Endoscopy","award":["16KT0190"],"award-info":[{"award-number":["16KT0190"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Systemic sclerosis (SSc) is often associated with dysphagia and esophageal dysmotility; however, only a few clinical studies on this topic have been conducted. Patients with SSc who underwent swallowing examinations and esophagography at our institution between 2010 and 2022 were included. A retrospective evaluation of the patients\u2019 backgrounds, autoantibody positivity, swallowing function, and esophageal motility was performed using medical charts. The association between dysphagia and esophageal dysmotility in patients with SSc and respective risk factors was investigated. Data were collected from 50 patients. Anti-topoisomerase I antibodies (ATA) and anti-centromere antibodies (ACA) were detected in 21 (42%) and 11 (22%) patients, respectively. Dysphagia was present in 13 patients (26%), and esophageal dysmotility in 34 patients (68%). ATA-positive patients had a higher risk for dysphagia (p = 0.027); ACA-positive patients had a significantly lower risk (p = 0.046). Older age and laryngeal sensory deficits were identified as risk factors for dysphagia; however, no risk factors for esophageal dysmotility were identified. No correlation was found between dysphagia and esophageal dysmotility. Esophageal dysmotility is more common in patients with SSc than in those with dysphagia. Autoantibodies can be predictors of dysphagia, and dysphagia must be carefully considered in ATA-positive and elderly patients with SSc.<\/jats:p>","DOI":"10.3390\/jcm12103448","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:02:11Z","timestamp":1684116131000},"page":"3448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Risk Factors for Dysphagia and Esophageal Dysmotility in Systemic Sclerosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Mariko","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-7237","authenticated-orcid":false,"given":"Rumi","family":"Ueha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"},{"name":"Swallowing Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-9140","authenticated-orcid":false,"given":"Ayumi","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-559X","authenticated-orcid":false,"given":"Hayakazu","family":"Sumida","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"},{"name":"Scleroderma Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-0973","authenticated-orcid":false,"given":"Tatsuya","family":"Yamasoba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrgastro.2016.99","article-title":"Current management of the gastrointestinal complications of systemic sclerosis","volume":"13","author":"Emmanuel","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1007\/s12325-022-02078-5","article-title":"Incidence Rate and Prevalence of Systemic Sclerosis and Systemic Sclerosis-Associated Interstitial Lung Disease in Japan: Analysis Using Japanese Claims Databases","volume":"39","author":"Kuwana","year":"2022","journal-title":"Adv. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: An American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"Khanna","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrrheum.2009.238","article-title":"Autoantibodies as predictive tools in systemic sclerosis","volume":"6","author":"Nihtyanova","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"587773","DOI":"10.3389\/fmed.2020.587773","article-title":"Classical Disease-Specific Autoantibodies in Systemic Sclerosis: Clinical Features, Gene Susceptibility, and Disease Stratification","volume":"7","author":"Yang","year":"2020","journal-title":"Front. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/2397198318786158","article-title":"Anti-RNA polymerase III antibodies in patients with suspected and definite systemic sclerosis: Why and how to screen","volume":"3","author":"Lazzaroni","year":"2018","journal-title":"J. Scleroderma Relat. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/rheumatology\/ken179","article-title":"The registry of the German Network for Systemic Scleroderma: Frequency of disease subsets and patterns of organ involvement","volume":"47","author":"Hunzelmann","year":"2008","journal-title":"Rheumatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s40744-021-00382-0","article-title":"Esophageal Dysfunction in Systemic Sclerosis: An Update","volume":"8","author":"Li","year":"2021","journal-title":"Rheumatol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e31780","DOI":"10.1097\/MD.0000000000031780","article-title":"Gastrointestinal involvement in systemic sclerosis: An updated review","volume":"101","author":"Nassar","year":"2022","journal-title":"Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/BOR.0000000000000645","article-title":"Gastrointestinal involvement in systemic sclerosis: An update","volume":"31","author":"McMahan","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.apmr.2004.11.049","article-title":"Initial psychometric assessment of a functional oral intake scale for dysphagia in stroke patients","volume":"86","author":"Crary","year":"2005","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00417897","article-title":"A penetration-aspiration scale","volume":"11","author":"Rosenbek","year":"1996","journal-title":"Dysphagia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.26502\/acbr.50170152","article-title":"Clinical Significance of Anti-U1 Ribonucleoprotein Antibody in Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis Patients: A Retrospective Observational Study","volume":"5","author":"Matsuda","year":"2020","journal-title":"Arch. Clin. Biomed. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00455-017-9845-8","article-title":"Relationship between Laryngeal Sensory Deficits, Aspiration, and Pneumonia in Patients with Dysphagia","volume":"33","author":"Kaneoka","year":"2018","journal-title":"Dysphagia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/hae.13655","article-title":"Bleeding and safety outcomes in persons with haemophilia A without inhibitors: Results from a prospective non-interventional study in a real-world setting","volume":"25","author":"Oldenburg","year":"2019","journal-title":"Haemophilia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00455-017-9809-z","article-title":"Reflections on Clinical and Statistical Use of the Penetration-Aspiration Scale","volume":"32","author":"Steele","year":"2017","journal-title":"Dysphagia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1177\/0003489419841398","article-title":"Predictors of Penetration-Aspiration in Parkinson\u2019s Disease Patients With Dysphagia: A Retrospective Analysis","volume":"128","author":"Gaeckle","year":"2019","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/01945998211049114","article-title":"Risk Factors for Aspiration Pneumonia After Receiving Liquid-Thickening Recommendations","volume":"167","author":"Masuda","year":"2022","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"965062","DOI":"10.1155\/2009\/965062","article-title":"Esophageal clearance patterns in normal older adults as documented with videofluoroscopic esophagram","volume":"2009","author":"Jou","year":"2009","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/lary.28852","article-title":"Esophageal Dysmotility is Common in Patients With Multiple System Atrophy","volume":"131","author":"Ueha","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_21","first-page":"169","article-title":"Oropharyngeal swallowing functions are impaired in patients with scleroderma","volume":"38","author":"Eyigor","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_22","first-page":"108","article-title":"Videofluorography swallow study in patients with systemic sclerosis: Correlation with clinical and radiological features","volume":"37","author":"Fraticelli","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s11547-009-0416-4","article-title":"Videofluorography swallow study of patients with systemic sclerosis","volume":"114","author":"Russo","year":"2009","journal-title":"Radiol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101666","DOI":"10.1016\/j.berh.2021.101666","article-title":"A practical approach to the evaluation and management of gastrointestinal symptoms in patients with systemic sclerosis","volume":"35","author":"Kaniecki","year":"2021","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/art.39432","article-title":"Characteristics and Survival of Anti-U1 RNP Antibody-Positive Patients With Connective Tissue Disease-Associated Pulmonary Arterial Hypertension","volume":"68","author":"Sobanski","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/art.39652","article-title":"The Role of Anti-U1 RNP Positivity in Predicting Survival in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: Angel or Demon? Comment on the Article by Sobanski et al","volume":"68","author":"Qian","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF02231782","article-title":"Pain and fatigue in patients with rheumatic disorders","volume":"12","author":"Mengshoel","year":"1993","journal-title":"Clin. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1442-2050.2010.01150.x","article-title":"Esophageal dysmotility associated with systemic sclerosis: A high-resolution manometry study","volume":"24","author":"Roman","year":"2011","journal-title":"Dis. Esophagus"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rutka, K., Garkowski, A., Karaszewska, K., and \u0141ebkowska, U. (2021). Imaging in Diagnosis of Systemic Sclerosis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020248"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/annrheumdis-2013-203889","article-title":"Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): Report from a single VEDOSS\/EUSTAR centre","volume":"74","author":"Lepri","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/1346-8138.14162","article-title":"Diagnostic criteria, severity classification and guidelines of systemic sclerosis","volume":"45","author":"Asano","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11938-008-0008-8","article-title":"Esophageal disease in progressive systemic sclerosis","volume":"11","author":"Ebert","year":"2008","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cgh.2016.08.034","article-title":"Esophageal Motor Abnormalities in Patients With Scleroderma: Heterogeneity, Risk Factors, and Effects on Quality of Life","volume":"15","author":"Crowell","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.semarthrit.2017.05.005","article-title":"High-resolution manometry compared with the University of California, Los Angeles Scleroderma Clinical Trials Consortium GIT 2.0 in Systemic Sclerosis","volume":"47","author":"Abozaid","year":"2017","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s10067-018-4026-1","article-title":"Esophageal high-resolution impedance manometry alterations in asymptomatic patients with systemic sclerosis: Prevalence, associations with disease features, and prognostic value","volume":"37","author":"Vettori","year":"2018","journal-title":"Clin. Rheumatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3448\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:34:22Z","timestamp":1760124862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,13]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jcm12103448"],"URL":"https:\/\/doi.org\/10.3390\/jcm12103448","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,13]]}}}