{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:07:12Z","timestamp":1788444432361,"version":"build-2803163510"},"reference-count":92,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007721","name":"Cure Spinal Muscular Atrophy","doi-asserted-by":"publisher","award":["PG010805"],"award-info":[{"award-number":["PG010805"]}],"id":[{"id":"10.13039\/100007721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007721","name":"Cure Spinal Muscular Atrophy","doi-asserted-by":"publisher","award":["GR-2021-12374579"],"award-info":[{"award-number":["GR-2021-12374579"]}],"id":[{"id":"10.13039\/100007721","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian Health Ministry","award":["PG010805"],"award-info":[{"award-number":["PG010805"]}]},{"name":"Italian Health Ministry","award":["GR-2021-12374579"],"award-info":[{"award-number":["GR-2021-12374579"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Fatigue, a common symptom, together with the characteristic of performance fatigability, are well-documented features of SMA that impact quality of life and function. Importantly, establishing associations between multidimensional self-reported fatigue scales and patient performance has proven difficult. This review was conducted to evaluate the various patient-reported fatigue scales applied in SMA, with the objective of considering the limitations and advantages of each measure. Variable use of fatigue-related nomenclature, including conflicting terminology interpretation, has affected assessment of physical fatigue attributes, specifically perceived fatigability. This review encourages the development of original patient-reported scales to enable perceived fatigability assessment, providing a potential complementary method of evaluating treatment response.<\/jats:p>","DOI":"10.3390\/jcm12103458","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:02:11Z","timestamp":1684116131000},"page":"3458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Measuring Fatigue and Fatigability in Spinal Muscular Atrophy (SMA): Challenges and Opportunities"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3648-0741","authenticated-orcid":false,"given":"Rafael S.","family":"Rodriguez-Torres","sequence":"first","affiliation":[{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Rehabilitation and Regenerative Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-8801","authenticated-orcid":false,"given":"David","family":"Uher","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Regenerative Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY 10115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6666-5628","authenticated-orcid":false,"given":"Giorgia","family":"Coratti","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Catholic University, 00135 Rome, Italy"},{"name":"Centro Clinico Nemo, U.O.C. 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