{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:34Z","timestamp":1787028634252,"version":"build-2736575974"},"reference-count":14,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ruhr-University of Bochum"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Ultrasound-accelerated thrombolysis (USAT) is an advanced interventional therapy for patients with intermediate\u2013high-risk pulmonary embolism (PE) who deteriorated on anticoagulation or for high-risk patients for whom systemic thrombolysis is contraindicated. The aim of this study is to investigate the safety and efficacy of this therapy with a focus on the improvement of vital signs and laboratory parameters. Seventy-nine patients with intermediate\u2013high-risk PE were treated with USAT from August 2020 to November 2022. The therapy significantly decreased the mean RV\/LV ratio from 1.2 \u00b1 0.22 to 0.9 \u00b1 0.2 (p &lt; 0.001) as well as the mean PAPs from 48.6 \u00b1 11 to 30.1 \u00b1 9.0 mmHg (p &lt; 0.001). The respiratory and heart rate decreased significantly (p &lt; 0.001). Serum creatinine decreased significantly from 1.0 \u00b1 0.35 to 0.9 \u00b1 0.3 (p &lt; 0.001). There were 12 access-associated complications, which could be treated conservatively. One patient had haemothorax after the therapy and had to be operated on. USAT is an effective therapy for patients with intermediate\u2013high-risk PE, with favourable hemodynamic, clinical, and laboratory outcomes.<\/jats:p>","DOI":"10.3390\/jcm12103459","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:02:11Z","timestamp":1684116131000},"page":"3459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Safety and Efficacy of Ultrasound-Accelerated Catheter-Directed Thrombolysis in Patients with Intermediate\u2013High-Risk Pulmonary Embolism: Bo-NE-Experience"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-9591","authenticated-orcid":false,"given":"Hani","family":"Al-Terki","sequence":"first","affiliation":[{"name":"Cardiology and Rhythmology Department, University Hospital St. Josef-Hospital Bochum, Ruhr University Bochum, Gudrunstra\u00dfe 56, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9548-6995","authenticated-orcid":false,"given":"Andreas","family":"M\u00fcgge","sequence":"additional","affiliation":[{"name":"Cardiology and Rhythmology Department, University Hospital St. Josef-Hospital Bochum, Ruhr University Bochum, Gudrunstra\u00dfe 56, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-0284","authenticated-orcid":false,"given":"Michael","family":"Gotzmann","sequence":"additional","affiliation":[{"name":"Cardiology and Rhythmology Department, University Hospital St. Josef-Hospital Bochum, Ruhr University Bochum, Gudrunstra\u00dfe 56, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Tiyerili","sequence":"additional","affiliation":[{"name":"Cardiology and Rhythmology, St.-Johannes Hospital Dortmund, 44137 Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-4684","authenticated-orcid":false,"given":"Marcus","family":"Franz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"M\u00f6bius-Winkler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-4167","authenticated-orcid":false,"given":"Abdelrahman","family":"Elhakim","sequence":"additional","affiliation":[{"name":"Cardiology Department, Schoen Hospital, 23730 Neustadt in Holstein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1161\/01.CIR.101.24.2817","article-title":"Short-Term Clinical Outcome of Patients With Acute Pulmonary Embolism, Normal Blood Pressure, and Echocardiographic Right Ventricular Dysfunction","volume":"101","author":"Grifoni","year":"2000","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC guidelines for the diagnosis and management of acute pul- monary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur. 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