{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:48:45Z","timestamp":1790138925640,"version":"4.0.1"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Non-anastomotic biliary strictures (NAS) are a common cause of morbidity and mortality after liver transplantation. Methods: All patients with NAS from 2008 to 2016 were retrospectively analyzed. The success rate and overall mortality of an ERCP-based stent program (EBSP) were the primary outcomes. Results: A total of 40 (13.9%) patients with NAS were identified, of which 35 patients were further treated in an EBSP. Furthermore, 16 (46%) patients terminated EBSP successfully, and nine (26%) patients died during the program. All deaths were caused by cholangitis. Of those, one (11%) patient had an extrahepatic stricture, while the other eight patients had either intrahepatic (3, 33%) or combined extra- and intrahepatic strictures (5, 56%). Risk factors of overall mortality were age (p = 0.03), bilirubin (p &lt; 0.0001), alanine transaminase (p = 0.006), and aspartate transaminase (p = 0.0003). The median duration of the stent program was 34 months (ITBL: 36 months; IBL: 10 months), and procedural complications were rare. Conclusions: EBSP is safe, but lengthy and successful in only about half the patients. Intrahepatic strictures were associated with an increased risk of cholangitis.<\/jats:p>","DOI":"10.3390\/jcm12103491","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:58:06Z","timestamp":1684288686000},"page":"3491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of Non-Anastomotic Biliary Strictures after Liver Transplantation: How Effective Is Our Current Treatment Strategy?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-3691","authenticated-orcid":false,"given":"Florian A.","family":"Michael","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireen","family":"Friedrich-Rust","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Erasmus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Ballo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mate","family":"Knabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph D.","family":"Steup","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-8369","authenticated-orcid":false,"given":"Marcus M.","family":"M\u00fccke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-7246","authenticated-orcid":false,"given":"Victoria T.","family":"M\u00fccke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai H.","family":"Peiffer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"G\u00f6rg\u00fcl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-8423","authenticated-orcid":false,"given":"Antonia","family":"Mondorf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-8145","authenticated-orcid":false,"given":"Wolf O.","family":"Bechstein","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Filmann","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Mathematical Modeling, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Bojunga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-9910","authenticated-orcid":false,"given":"Fabian","family":"Finkelmeier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.bbadis.2017.06.013","article-title":"Post-transplant cholangiopathy: Classification, pathogenesis, and preventive strategies. Biochimica et biophysica acta","volume":"1864","author":"Porte","year":"2018","journal-title":"Mol. Basis Dis."},{"key":"ref_2","first-page":"316","article-title":"Management of Biliary Strictures After Liver Transplantation","volume":"11","author":"Villa","year":"2015","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/00365520600664375","article-title":"Biliary complications after liver transplantation: A review","volume":"41","author":"Verdonk","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_4","first-page":"379","article-title":"Biliary reconstruction, its complications and management of biliary complications after adult liver transplantation: A systematic review of the incidence, risk factors and outcome","volume":"24","author":"Akamatsu","year":"2011","journal-title":"Transpl. Int. Off. J. Eur. Soc. Organ Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.gie.2012.08.034","article-title":"Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: Outcomes after maximal stent therapy","volume":"77","author":"Hsieh","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1007\/s00268-007-9217-x","article-title":"Biliary complications after duct-to-duct biliary reconstruction in living-donor liver transplantation: Causes and treatment","volume":"31","author":"Tashiro","year":"2007","journal-title":"World J. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1067\/S0016-5107(03)00011-7","article-title":"Long-term outcomes for patients with post-liver transplant anastomotic biliary strictures treated by endoscopic stent placement","volume":"58","author":"Morelli","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"ref_8","first-page":"505","article-title":"Endoscopic treatment of pediatric post-transplant biliary complications is safe and effective","volume":"27","author":"Kodde","year":"2015","journal-title":"Dig. Endosc. Off. J. Jpn. Gastroenterol. Endosc. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1055\/s-2003-40242","article-title":"Complete bile duct sequestration after liver transplantation, caused by ischemic-type biliary lesions","volume":"35","author":"Radke","year":"2003","journal-title":"Endoscopy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/lt.20644","article-title":"Long-term outcome of endoscopic treatment of biliary strictures after liver transplantation","volume":"12","author":"Graziadei","year":"2006","journal-title":"Liver Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0016-5107(98)70344-X","article-title":"Endoscopic management of biliary strictures in liver transplant recipients: Effect on patient and graft survival","volume":"47","author":"Rizk","year":"1998","journal-title":"Gastrointest. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.gie.2008.09.057","article-title":"Endoscopic treatment with multiple stents for post-liver-transplantation nonanastomotic biliary strictures","volume":"69","author":"Tabibian","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2214\/ajr.149.3.485","article-title":"Cholangiographic findings in hepatic artery occlusion after liver transplantation","volume":"149","author":"Zajko","year":"1987","journal-title":"AJR. Am. J. Roentgenol."},{"key":"ref_14","first-page":"1107","article-title":"Clinical outcome of ischemic-type biliary complications after liver transplantation","volume":"25","author":"Gores","year":"1993","journal-title":"Transplant. Proc."},{"key":"ref_15","first-page":"13","article-title":"Endoskopische Therapie isch\u00e4mietypischer bili\u00e4rer L\u00e4sionen (ITBL) bei Patienten nach orthotoper Lebertransplantation","volume":"37","author":"Hintze","year":"1999","journal-title":"Z. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jhbp.512","article-title":"Tokyo Guidelines 2018: Diagnostic criteria and severity grading of acute cholangitis (with videos)","volume":"25","author":"Kiriyama","year":"2018","journal-title":"J. Hepato-Biliary-Pancreat. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/a-1735-3864","article-title":"S3-Leitlinie Pankreatitis\u2014Leitlinie der Deutschen Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)\u2014September 2021\u2014AWMF Registernummer 021-003","volume":"60","author":"Beyer","year":"2022","journal-title":"Z. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/bjs.7043","article-title":"Similar liver transplantation survival with selected cardiac death donors and brain death donors","volume":"97","author":"Dubbeld","year":"2010","journal-title":"Br. J. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/lt.21361","article-title":"Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors","volume":"14","author":"Chan","year":"2008","journal-title":"Liver Transplant."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/lt.21853","article-title":"Liver transplantation following donation after cardiac death: An analysis using matched pairs","volume":"15","author":"Pine","year":"2009","journal-title":"Liver Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.gie.2012.04.474","article-title":"Optimized endoscopic treatment of ischemic-type biliary lesions after liver transplantation","volume":"76","author":"Zoepf","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.3748\/wjg.15.3725","article-title":"Endoscopic management of biliary strictures after liver transplantation","volume":"15","author":"Williams","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1034\/j.1600-6143.2003.00165.x","article-title":"Risk factors for and clinical course of non-anastomotic biliary strictures after liver transplantation","volume":"3","author":"Guichelaar","year":"2003","journal-title":"Am. J. Transplant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.6002\/ect.2020.0032","article-title":"Ischemic-Type Biliary Lesions After Liver Transplant: Factors Causing Early-Onset Versus Late-Onset Disease","volume":"18","author":"Dobrindt","year":"2020","journal-title":"Exp. Clin. Transplant."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.4253\/wjge.v7.i6.606","article-title":"Endoscopic management of biliary complications after liver transplantation: An evidence-based review","volume":"7","author":"Dumonceau","year":"2015","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_26","first-page":"258","article-title":"Endoscopic management of biliary complications after orthotopic liver transplantation","volume":"44","author":"Hintze","year":"1997","journal-title":"Hepato-Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.gie.2017.02.031","article-title":"Asia-Pacific consensus guidelines for endoscopic management of benign biliary strictures","volume":"86","author":"Hu","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1055\/a-0659-9864","article-title":"Endoscopic biliary stenting: Indications, choice of stents, and results: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline\u2014Updated October 2017","volume":"50","author":"Dumonceau","year":"2018","journal-title":"Endoscopy"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.gie.2014.11.019","article-title":"The role of ERCP in benign diseases of the biliary tract","volume":"81","author":"Chathadi","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"833","DOI":"10.5946\/ce.2021.052","article-title":"Stent versus Balloon Dilation for the Treatment of Dominant Strictures in Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis","volume":"54","author":"Ferreira","year":"2021","journal-title":"Clin. Endosc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/liv.15194","article-title":"The biliary microbiome in ischaemic-type biliary lesions can be shaped by stenting but is resilient to antibiotic treatment","volume":"42","author":"Klein","year":"2022","journal-title":"Liver Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3491\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:35:57Z","timestamp":1760124957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jcm12103491"],"URL":"https:\/\/doi.org\/10.3390\/jcm12103491","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}