{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:06:08Z","timestamp":1789200368410,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BUONA S.P.A","award":["Alfieri 8-50019-Sesto Fiorentio (FI)"],"award-info":[{"award-number":["Alfieri 8-50019-Sesto Fiorentio (FI)"]}]},{"name":"BUONA S.P.A","award":["05014810484"],"award-info":[{"award-number":["05014810484"]}]},{"name":"P. IVA","award":["Alfieri 8-50019-Sesto Fiorentio (FI)"],"award-info":[{"award-number":["Alfieri 8-50019-Sesto Fiorentio (FI)"]}]},{"name":"P. IVA","award":["05014810484"],"award-info":[{"award-number":["05014810484"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Allergic Rhinitis (AR) is a chronic inflammatory disease of sino-nasal mucosa, is IgE-mediated, and affects 10\u201340% of the global population. This study aimed to compare the efficacy of nasal administration of Beclomethasone Dipropionate (BDP) delivered via Spray-sol with nasal spray in patients suffering from AR. We included 28 AR patients assigned to one of the two following treatments: the Spray-sol group (BDP via Spray-sol) (n = 13) and the spray group (BDP using a common nasal spray) (n = 15). Both treatments were administered twice daily for 4 weeks. A nasal endoscopy evaluation and Total Nasal Symptom Score were performed at baseline and after treatment. The Spray-sol group showed better results than the spray group regarding nasal endoscopy (edema, p &lt; 0.01; irritation, p &lt; 0.01; secretion, p &lt; 0.01) and nasal symptoms (nasal congestion, p &lt; 0.05; rhinorrhea, p &lt; 0.05; sneezing, p &lt; 0.05; and total score, p &lt; 0.05). No side effects were recorded. These data supported the fact that the use of BDP delivered with Spray-sol is more effective than BDP nasal spray in AR patients. Further studies are needed to confirm these encouraging results.<\/jats:p>","DOI":"10.3390\/jcm12103492","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:58:06Z","timestamp":1684288686000},"page":"3492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Intranasal Steroid Application Using Nasal Spray and Spray-Sol to Treat Allergic Rhinitis: A Preliminary Investigation"],"prefix":"10.3390","volume":"12","author":[{"given":"Antonio","family":"Moffa","sequence":"first","affiliation":[{"name":"Integrated Therapies in Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"},{"name":"School of medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-3237","authenticated-orcid":false,"given":"Lucrezia","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Integrated Therapies in Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Unit of Measurements and Biomedical Instrumentation, Department of Engineering, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Carnuccio","sequence":"additional","affiliation":[{"name":"School of medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-0755","authenticated-orcid":false,"given":"Rodolfo","family":"Lugo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Grupo Medico San Pedro, Monterrey 64660, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-5331","authenticated-orcid":false,"given":"Peter","family":"Baptista","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Clinica Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"ENT Department, Al Zahra Private Hospital Dubai, Dubai 23614, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuele","family":"Casale","sequence":"additional","affiliation":[{"name":"Integrated Therapies in Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy"},{"name":"School of medicine, Universit\u00e0 Campus Bio-Medico di Roma, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1586\/1744666X.2015.1086645","article-title":"From IgE to clinical trials of allergic rhinitis","volume":"11","author":"Ciprandi","year":"2015","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines\u20132016 revision","volume":"140","author":"Bousquet","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaci.2019.06.049","article-title":"Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence","volume":"145","author":"Bousquet","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.otpol.2013.12.003","article-title":"Intranasal glucocorticosteroids\u2013not only in allergic rhinitis In the 40th anniversary of intranasal glucocorticosteroids\u2019 introduction","volume":"68","author":"Nowicka","year":"2014","journal-title":"Otolaryngol. Pol. = Polish Otolaryngol."},{"key":"ref_5","first-page":"81","article-title":"Post-operative nebulized sodium hyaluronate versus spray after functional endoscopic sinus surgery for chronic rhinosinusitis","volume":"31","author":"Casale","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_6","first-page":"1213","article-title":"Impact of intranasal nebulized ectoine on morbidity and short-term quality of life after pediatric adenoidectomy","volume":"34","author":"Moffa","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_7","first-page":"1935","article-title":"Potential role of topical ectoine for prevention of pediatric upper respiratory tract infection: A preliminary observational study","volume":"33","author":"Moffa","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_8","first-page":"4","article-title":"Open and clean: The healthy nose","volume":"90","author":"Ciprandi","year":"2019","journal-title":"Acta Bio Medica Atenei Parm."},{"key":"ref_9","unstructured":"U.S. (2022, December 19). Department of Health and Human Services; Food and Drug Administration; Center for Drug Evaluation and Research (CDER). FDA Guidance for Industry, Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products\u2014Chemistry, Manufacturing, and Controls Documentation, Available online: https:\/\/www.fda.gov\/media\/70857\/download."},{"key":"ref_10","first-page":"e2023034","article-title":"Choosing nasal devices: A dilemma in clinical practice","volume":"94","author":"Varricchio","year":"2023","journal-title":"Acta Biomed."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40136-012-0003-4","article-title":"Topical Drug Delivery for Chronic Rhinosinusitis","volume":"1","author":"Liang","year":"2013","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1089\/jam.2007.0569","article-title":"Devices for aerosol delivery to treat sinusitis","volume":"20","author":"Laube","year":"2007","journal-title":"J. Aerosol Med. Depos. Clear. Eff. Lung"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijporl.2016.03.015","article-title":"Hyaluronic acid and upper airway inflammation in pediatric population: A systematic review","volume":"85","author":"Casale","year":"2016","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MOO.0b013e32834dfa80","article-title":"Nasal irrigation with or without drugs: The evidence","volume":"20","author":"Adappa","year":"2012","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4602651","DOI":"10.1155\/2019\/4602651","article-title":"Nasal Delivery Devices: A Comparative Study on Cadaver Model","volume":"2019","author":"Moffa","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2147\/DDDT.S25199","article-title":"Novel drug-delivery systems for patients with chronic rhinosinusitis","volume":"6","author":"Albu","year":"2012","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1017\/S0022215100107418","article-title":"The nasal valve: A physiological and clinical study","volume":"102","author":"Jones","year":"1988","journal-title":"J. Laryngol. Otol."},{"key":"ref_18","first-page":"1","article-title":"Local and systemic safety of intranasal corticosteroids","volume":"22","author":"Sastre","year":"2012","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2058738420941757","DOI":"10.1177\/2058738420941757","article-title":"Could nasal irrigation and oral rinse reduce the risk for COVID-19 infection?","volume":"34","author":"Casale","year":"2020","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2500\/ajra.2014.28.4045","article-title":"The potential role of hyaluronan in minimizing symptoms and preventing exacerbations of chronic rhinosinusitis","volume":"28","author":"Casale","year":"2014","journal-title":"Am. J. Rhinol. Allergy"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3492\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:35:56Z","timestamp":1760124956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jcm12103492"],"URL":"https:\/\/doi.org\/10.3390\/jcm12103492","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}