{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T19:15:34Z","timestamp":1774552534963,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Primary headaches are known to be associated with multiple sclerosis (MS), but previous studies concerning this relationship are not conclusive. Nowadays, there are no studies assessing the prevalence of headaches in Polish MS patients. The aim of the study was to assess the prevalence and characterise headaches in MS patients treated with disease-modifying therapies (DMTs). In a cross-sectional study of 419 consecutive RRMS patients, primary headaches were diagnosed according to the International Classification of Headache Disorders (ICHD-3) criteria. Primary headaches were observed in 236 (56%) of RRMS patients, with a higher prevalence in women (ratio of 2:1). The most common was migraine 174 (41%) (migraine with aura 80 (45%), migraine without aura 53 (30%), and probable migraine without aura 41 (23%); less frequent was tension-type headache 62 (14%). Female sex was a risk factor for migraines but not for tension-type headaches (p = 0.002). Migraines mostly started before MS onset (p = 0.023). Migraine with aura was associated with older age, longer disease duration (p = 0.028), and lower SDMT (p = 0.002). Longer DMT time was associated with migraine (p = 0.047), particularly migraine with aura (p = 0.035). Typical for migraine with aura were headaches during clinical isolated syndrome (CIS) (p = 0.001) and relapses (p = 0.025). Age and type of CIS, oligoclonal band presence, family MS history, EDSS, 9HTP, T25FW, and type of DMT did not correlate with headache. Headaches are present in more than half of MS patients treated with DMTs; migraines occur almost three times more frequently than tension-type headaches. Migraines with aura headaches during CIS and relapses are typical. Migraine in MS patients had high severity and typical migraine characteristics. DMTs had no correlation with the presence or type of headache.<\/jats:p>","DOI":"10.3390\/jcm12103518","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:03:58Z","timestamp":1684393438000},"page":"3518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Characteristics of Headache in Multiple Sclerosis Patients: A Cross-Sectional Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Iwona","family":"Ro\u015bciszewska-\u017bukowska","sequence":"first","affiliation":[{"name":"St. Jadwiga Queen Clinical Hospital No. 2, Lwowska 60, 35-301 Rzeszow, Poland"},{"name":"Institute of Medical Sciences, Medical College, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-3553","authenticated-orcid":false,"given":"Sabina","family":"Galiniak","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Medical College, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halina","family":"Bartosik-Psujek","sequence":"additional","affiliation":[{"name":"St. Jadwiga Queen Clinical Hospital No. 2, Lwowska 60, 35-301 Rzeszow, Poland"},{"name":"Institute of Medical Sciences, Medical College, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.msard.2018.02.016","article-title":"Prevalence of Multiple Sclerosis in Poland","volume":"21","author":"Brola","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_2","unstructured":"(2018). GBD 2016 Headache Collaborators Global, Regional, and National Burden of Migraine and Tension-Type Headache, 1990-2016: A Systematic Analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 17, 954\u2013976."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s10194-022-01402-2","article-title":"The Global Prevalence of Headache: An Update, with Analysis of the Influences of Methodological Factors on Prevalence Estimates","volume":"23","author":"Stovner","year":"2022","journal-title":"J. Headache Pain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s10194-020-01208-0","article-title":"Migraine Remains Second among the World\u2019s Causes of Disability, and First among Young Women: Findings from GBD2019","volume":"21","author":"Steiner","year":"2020","journal-title":"J. Headache Pain"},{"key":"ref_5","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018). Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 354 Diseases and Injuries for 195 Countries and Territories, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1789\u20131858."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1212\/WNL.0b013e318259e1b2","article-title":"\u201cUndiagnosing\u201d Multiple Sclerosis: The Challenge of Misdiagnosis in MS","volume":"78","author":"Solomon","year":"2012","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101946","DOI":"10.1016\/j.msard.2020.101946","article-title":"Why Do Multiple Sclerosis and Migraine Coexist?","volume":"40","author":"Say","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_8","first-page":"2055217316682976","article-title":"Migraine and Frequent Tension-Type Headache Are Not Associated with Multiple Sclerosis in a Norwegian Case-Control Study","volume":"2","author":"Gustavsen","year":"2016","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/j.1526-4610.2011.01962.x","article-title":"Headache in Systemic Lupus Erythematosus vs Multiple Sclerosis: A Prospective Comparative Study","volume":"51","author":"Katsiari","year":"2011","journal-title":"Headache"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1468-2982.2008.01662.x","article-title":"Headache and Multiple Sclerosis: A Population-Based Case-Control Study in Catania, Sicily","volume":"28","author":"Nicoletti","year":"2008","journal-title":"Cephalalgia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jocn.2020.06.021","article-title":"The Prevalence of Migraine in Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis","volume":"79","author":"Mirmosayyeb","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10072-015-2146-9","article-title":"Headache in Multiple Sclerosis and Autoimmune Disorders","volume":"36","author":"Prone","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e01830","DOI":"10.1002\/brb3.1830","article-title":"The Epidemiology of Primary Headaches in Patients with Multiple Sclerosis","volume":"11","author":"Wang","year":"2021","journal-title":"Brain Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1468-2982.2004.00790.x","article-title":"Prevalence of Primary Headaches in People with Multiple Sclerosis","volume":"24","author":"Rigamonti","year":"2004","journal-title":"Cephalalgia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.phm.0000171012.86932.10","article-title":"Migraines Linked to Interferon-Beta Treatment of Multiple Sclerosis","volume":"84","author":"Khromov","year":"2005","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1526-4610.2012.02146.x","article-title":"The Impact of Interferon Beta and Natalizumab on Comorbid Migraine in Multiple Sclerosis","volume":"52","author":"Villani","year":"2012","journal-title":"Headache"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1590\/0004-282x20190100","article-title":"Migraine in 746 Patients with Multiple Sclerosis","volume":"77","author":"Fragoso","year":"2019","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis","volume":"50","author":"McDonald","year":"2001","journal-title":"Ann. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating Neurologic Impairment in Multiple Sclerosis: An Expanded Disability Status Scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Simpson, R.J., McLean, G., Guthrie, B., Mair, F., and Mercer, S.W. (2014). Physical and Mental Health Comorbidity Is Common in People with Multiple Sclerosis: Nationally Representative Cross-Sectional Population Database Analysis. BMC Neurol., 14.","DOI":"10.1186\/1471-2377-14-128"},{"key":"ref_22","first-page":"135","article-title":"Some Aspects of the Natural History of Disseminated Sclerosis","volume":"21","author":"McALPINE","year":"1952","journal-title":"Q. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104152","DOI":"10.1016\/j.msard.2022.104152","article-title":"Multiple Sclerosis and Migraine: Links, Management and Implications","volume":"68","author":"Mrabet","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40064-015-0818-9","article-title":"Status Migrainosus as an Initial Presentation of Multiple Sclerosis","volume":"4","author":"Alroughani","year":"2015","journal-title":"Springerplus"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00702-018-1959-0","article-title":"Headache in the Course of Multiple Sclerosis: A Prospective Study","volume":"126","author":"Gebhardt","year":"2019","journal-title":"J. Neural Transm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.msard.2018.09.022","article-title":"Headache Characteristics in Multiple Sclerosis","volume":"27","author":"Beckmann","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10194-010-0237-9","article-title":"Migraine Is Comorbid with Multiple Sclerosis and Associated with a More Symptomatic MS Course","volume":"11","author":"Kister","year":"2010","journal-title":"J. Headache Pain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1526-4610.2005.05136.x","article-title":"The Association of Brainstem Lesions with Migraine-like Headache: An Imaging Study of Multiple Sclerosis","volume":"45","author":"Gee","year":"2005","journal-title":"Headache"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/NRL.0b013e3181906fc9","article-title":"Headaches in the Different Phases of Relapsing-Remitting Multiple Sclerosis: A Tendency for Stabbing Headaches during Relapses","volume":"15","author":"Ozer","year":"2009","journal-title":"Neurologist"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.clineuro.2016.01.017","article-title":"Headaches in Multiple Sclerosis: Cross-Sectional Study of a Multiethnic Population","volume":"143","author":"Wang","year":"2016","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1468-1331.2008.02406.x","article-title":"Prevalence of Migraine, Tension-Type Headache and Trigeminal Neuralgia in Multiple Sclerosis","volume":"16","author":"Putzki","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"A83","DOI":"10.1186\/1129-2377-16-S1-A83","article-title":"P037. Headache in Multiple Sclerosis: Prevalence and Clinical Features in a Case Control-Study","volume":"16","author":"Terlizzi","year":"2015","journal-title":"J. Headache Pain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"P171","DOI":"10.1186\/1129-2377-14-S1-P171","article-title":"Headache as a Symptom of Multiple Sclerosis","volume":"14","author":"Kalamatas","year":"2013","journal-title":"J. Headache Pain"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"M\u00f6hrke, J., Kropp, P., and Zettl, U.K. (2013). Headaches in Multiple Sclerosis Patients Might Imply an Inflammatorial Process. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069570"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1212\/01.wnl.0000252808.97649.21","article-title":"Migraine Prevalence, Disease Burden, and the Need for Preventive Therapy","volume":"68","author":"Lipton","year":"2007","journal-title":"Neurology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"944791","DOI":"10.3389\/fneur.2022.944791","article-title":"Immunologic Aspects of Migraine: A Review of Literature","volume":"13","author":"Salahi","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12974-021-02229-5","article-title":"Headache and Immunological\/Autoimmune Disorders: A Comprehensive Review of Available Epidemiological Evidence with Insights on Potential Underlying Mechanisms","volume":"18","author":"Biscetti","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"874193","DOI":"10.3389\/fneur.2022.874193","article-title":"Dural Immune Cells, CGRP, and Migraine","volume":"13","author":"Balcziak","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_39","first-page":"9","article-title":"Headache in Multiple Sclerosis from a Different Perspective: A Prospective Study","volume":"9","year":"2018","journal-title":"J. Clin. Exp. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3389\/fneur.2020.00778","article-title":"Pain in NMOSD and MOGAD: A Systematic Literature Review of Pathophysiology, Symptoms, and Current Treatment Strategies","volume":"11","author":"Asseyer","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11916-017-0620-1","article-title":"Headache in Neuromyelitis Optica","volume":"21","author":"Robbins","year":"2017","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/j.1526-4610.2007.00818.x","article-title":"Cortical Spreading Depression and Estrogen","volume":"47","author":"Kudo","year":"2007","journal-title":"Headache J. Head Face Pain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.17219\/acem\/68944","article-title":"The Relationship between Event-Related Potentials, Stress Perception and Personality Type in Patients with Multiple Sclerosis without Cognitive Impairment: A Pilot Study","volume":"27","author":"Kotas","year":"2018","journal-title":"Adv. Clin Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/1352458507085551","article-title":"Lifetime and Actual Prevalence of Pain and Headache in Multiple Sclerosis","volume":"14","author":"Colombo","year":"2008","journal-title":"Mult. Scler."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.410390304","article-title":"Intramuscular Interferon Beta-1a for Disease Progression in Relapsing Multiple Sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)","volume":"39","author":"Jacobs","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(03)12512-3","article-title":"Interferons in Relapsing Remitting Multiple Sclerosis: A Systematic Review","volume":"361","author":"Filippini","year":"2003","journal-title":"Lancet"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0404.2011.01532.x","article-title":"Frequency and Severity of Headache Is Worsened by Interferon-\u03b2 Therapy in Patients with Multiple Sclerosis","volume":"125","author":"Patti","year":"2012","journal-title":"Acta Neurol. Scand"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2147\/JPR.S230680","article-title":"Interferon-Beta-Induced Headache in Patients with Multiple Sclerosis: Frequency and Characterization","volume":"13","author":"Elmazny","year":"2020","journal-title":"J. Pain Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/head.12725","article-title":"Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis","volume":"56","author":"Borkum","year":"2016","journal-title":"Headache"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1177\/0333102417727535","article-title":"Perceived Triggers of Primary Headache Disorders: A Meta-Analysis","volume":"38","author":"Pellegrino","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0333102412437390","article-title":"The Premonitory Phase of Migraine and Migraine Management","volume":"33","author":"Becker","year":"2013","journal-title":"Cephalalgia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/01.WNL.0000052998.58526.A9","article-title":"Premonitory Symptoms in Migraine: An Electronic Diary Study","volume":"60","author":"Giffin","year":"2003","journal-title":"Neurology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1038\/s41598-021-84102-2","article-title":"Mitochondrial Function and Oxidative Stress Markers in Higher-Frequency Episodic Migraine","volume":"11","author":"Gross","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Togha, M., Razeghi Jahromi, S., Ghorbani, Z., Ghaemi, A., and Rafiee, P. (2019). An Investigation of Oxidant\/Antioxidant Balance in Patients with Migraine: A Case-Control Study. BMC Neurol., 19.","DOI":"10.1186\/s12883-019-1555-4"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neuint.2013.08.009","article-title":"Oxidative Modification of Serum Proteins in Multiple Sclerosis","volume":"63","author":"Galiniak","year":"2013","journal-title":"Neurochem. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7905148","DOI":"10.1155\/2017\/7905148","article-title":"Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment","volume":"2017","author":"Galiniak","year":"2017","journal-title":"Oxid Med. Cell. Longev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s10194-023-01575-4","article-title":"Migraine Symptoms, Healthcare Resources Utilization and Disease Burden in a Large Polish Migraine Cohort: Results from \u2019Migraine in Poland\u2019-a Nationwide Cross-Sectional Survey","volume":"24","author":"Nowaczewska","year":"2023","journal-title":"J. Headache Pain"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/head.14319","article-title":"Headache Associated with COVID-19: Epidemiology, Characteristics, Pathophysiology, and Management","volume":"62","year":"2022","journal-title":"Headache"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3518\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:36:44Z","timestamp":1760125004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/10\/3518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jcm12103518"],"URL":"https:\/\/doi.org\/10.3390\/jcm12103518","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]}}}